SETBP1 overexpression acts in the place of class-defining mutations to drive FLT3-ITD-mutant AML

Autor: Pacharne, Suruchi, Dovey, Oliver M, Cooper, Jonathan L, Gu, Muxin, Friedrich, Mathias J, Rajan, Sandeep S, Barenboim, Maxim, Collord, Grace, Vijayabaskar, MS, Ponstingl, Hannes, De Braekeleer, Etienne, Bautista, Ruben, Mazan, Milena, Rad, Roland, Tzelepis, Konstantinos, Wright, Penny, Gozdecka, Malgorzata, Vassiliou, George S

Advances in cancer genomics have revealed genomic classes of acute myeloid leukemia (AML) characterized by class-defining mutations, such as chimeric fusion genes or in genes such as NPM1, MLL, and CEBPA. These class-defining mutations frequently syn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5ea258be96adc40110c17e5e335f31

Comparative analysis of thermophilic and mesophilic proteins using Protein Energy Networks

Autor: Vishveshwara Saraswathi, Vijayabaskar MS

Publikováno v: BMC Bioinformatics, Vol 11, Iss Suppl 1, p S49 (2010)

Abstract Background Thermophilic proteins sustain themselves and function at higher temperatures. Despite their structural and functional similarities with their mesophilic homologues, they show enhanced stability. Various comparative studies at geno

Externí odkaz: https://doaj.org/article/c23382415b87464e8df36a0523d1f36b

The Longitudinal Dynamics and Natural History of Clonal Hematopoiesis

Autor: Fabre, Margarete A, Guillherme de Almeida, Jose, Fiorillo, Edoardo, Mitchell, Emily, Damaskou, Aristi, Rak, Justyna, Orru, Valeria, Marongiu, Michele, Vijayabaskar, MS, Baxter, Joanna E, Hardy, Claire, Abascal, Federico, Spencer Chapman, Michael, Williams, Nicholas, Nangalia, Jyoti, Martincorena, Inigo, Campbell, Peter J, Mckinney, Eoin F, Cucca, Francesco, Gerstung, Moritz, Vassiliou, George S

Publikováno v: In Blood 4 December 2021 138 Supplement 2

PiggyBac mutagenesis and exome sequencing identify genetic driver landscapes and potential therapeutic targets of EGFR-mutant gliomas

Autor: Noorani, Imran, De La Rosa, Jorge, Choi, Yoon Ha, Strong, Alexander, Ponstingl, Hannes, Vijayabaskar, MS, Lee, Jusung, Lee, Eunmin, Richard-Londt, Angela, Friedrich, Mathias, Furlanetto, Federica, Fuente, Rocio, Banerjee, Ruby, Yang, Fengtang, Law, Frances, Watts, Colin, Rad, Roland, Vassiliou, George, Kim, Jong Kyoung, Santarius, Thomas, Brandner, Sebastian, Bradley, Allan

Glioma is the most common intrinsic brain tumor and also occurs in the spinal cord. Activating EGFR mutations are common in IDH1 wild-type gliomas. However, the cooperative partners of EGFR driving gliomagenesis remain poorly understood. RESULTS: We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::034dc6fa86d7b3630edf32a932b03f8d

Preleukemic single-cell landscapes reveal mutation-specific mechanisms and gene programs predictive of AML patient outcomes.

Autor: Isobe T; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Kucinski I; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Barile M; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Wang X; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Hannah R; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Bastos HP; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Chabra S; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Vijayabaskar MS; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Sturgess KHM; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Williams MJ; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Giotopoulos G; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Marando L; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Li J; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Rak J; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK; Hematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, UK., Gozdecka M; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK; Hematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, UK., Prins D; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Shepherd MS; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Watcham S; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Green AR; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Kent DG; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK; York Biomedical Research Institute, Department of Biology, University of York, York, UK., Vassiliou GS; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK; Hematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, UK., Huntly BJP; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Wilson NK; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK. Electronic address: nkw22@cam.ac.uk., Göttgens B; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK. Electronic address: bg200@cam.ac.uk.

Publikováno v: Cell genomics [Cell Genom] 2023 Oct 27; Vol. 3 (12), pp. 100426. Date of Electronic Publication: 2023 Oct 27 (Print Publication: 2023).