Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Vijaya Tirunagaru"'
Autor:
Masaya Nishino, Kenichi Suda, Takamasa Koga, Shuta Ohara, Toshio Fujino, Junichi Soh, Vijaya Tirunagaru, Avanish Vellanki, Robert C. Doebele, Tetsuya Mitsudomi
Publikováno v:
Thoracic Cancer, Vol 12, Iss 10, Pp 1511-1516 (2021)
Abstract Background Approximately 10% of non‐small cell lung cancers (NSCLCs) that harbor epidermal growth factor receptor (EGFR) gene mutations have in‐frame insertions in exon 20 of the EGFR gene. These tumors do not usually respond to currentl
Externí odkaz:
https://doaj.org/article/113f3c44e4bf4bd88a1b39cc70faedeb
Autor:
Francois-Clement Bidard, Diana Bello Roufai, Arielle J. Medford, Vijaya Tirunagaru, Robert C. Doebele, Aditya Bardia
Publikováno v:
Cancer Research. 83:P6-10
Background: Murine double minute 2 (MDM2), a potent negative regulator of p53, promotes tumorigenesis if dysregulated. MDM2 dysregulation occurs via different mechanisms, including MDM2 gene amplification, MDM2 overexpression, and loss of cyclin-depe
Autor:
Varsha Ananthapadmanabhan, Thomas C. Frost, Kara M. Soroko, Aine Knott, Brianna Magliozzi, Prafulla C. Gokhale, Vijaya Tirunagaru, Robert C. Doebele, James A. DeCaprio
Publikováno v:
Journal of Investigative Dermatology. 142:2837
Autor:
Mattia Marinucci, Gaia Bianco, Mairene Coto-Llierena, John Gallon, Venkatesh Kancherla, Federica Panebianco, Stephanie Taha-Mehlitz, Sumana Srivatsa, Niko Beerenwinkel, Hesam Montazeri, Vijaya Tirunagaru, Marta De Menna, Caner Ercan, Ahmed Dahmani, Elodie Montaudon, Marianna Kruithof-de Julio, Luigi M. Terracciano, Rinath M. Jeselsohn, Robert C. Doebele, François-Clément Bidard, Elisabetta Marangoni, Charlotte K. Y. Ng, Salvatore Piscuoglio
Publikováno v:
Cancer Research. 82:3984-3984
Introduction: GATA3 is critical for the development of the mammary gland and the loss of its expression alters the estrogen receptor (ER) transcriptional program. Approximately 70%-80% of all breast cancers are ER-positive and 15-18% of them harbor G
Autor:
Takamasa, Koga, Kenichi, Suda, Masaya, Nishino, Toshio, Fujino, Shuta, Ohara, Akira, Hamada, Junichi, Soh, Vijaya, Tirunagaru, Avanish, Vellanki, Robert C, Doebele, Tetsuya, Mitsudomi
Publikováno v:
Transl Lung Cancer Res
BACKGROUND: HER2 (ERBB2) activating mutations are present in 2–3% of lung adenocarcinomas; however, no targeted therapy is approved for HER2-altered lung cancers. A novel pan-HER inhibitor, tarloxotinib, is designed to release the active form (tarl
Autor:
Mrinal Gounder, Gary Schwartz, Robin Jones, Shreyaskumar Patel, Silvia Stacchiotti, Andrew Wagner, Vijaya Tirunagaru, Naisargee Shah, Richard Bryce, Robert Doebele
Publikováno v:
Molecular Cancer Therapeutics. 20:P031-P031
Background: p53 plays a central role in tumor suppression and maintenance of genome integrity. Murine double minute 2 (MDM2) is a ubiquitin ligase that inhibits p53 transcriptional activity and induces p53 degradation through ubiquitination. MDM2 amp
Autor:
Varsha Ananthapadmanabhan, Aine Knott, Kara M. Soroko, Prafulla C. Gokhale, Vijaya Tirunagaru, Robert Doebele, James A. DeCaprio
Publikováno v:
Molecular Cancer Therapeutics. 20:P203-P203
Background: MCC is a highly aggressive neuroendocrine carcinoma of the skin with a poor overall prognosis. Current treatment options include surgery and radiation therapy for local MCC tumor and checkpoint blockade therapy for advanced disease. Howev
Autor:
Maria-Jesus Blanco, Quinn Coughlin, Dario Doller, Hopper Allen T, Robichaud Albert Jean, Vijaya Tirunagaru
Publikováno v:
Journal of medicinal chemistry. 62(13)
Medicinal chemists are accountable for embedding the appropriate drug target profile into the molecular architecture of a clinical candidate. An accurate characterization of the functional effects following binding of a drug to its biological target
Autor:
Kari Ronningen, Yakov Pesah, Brooke W. Middlebrooks, John R. Zysk, Vijaya Tirunagaru, Graeme Mardon, Heather Burgess, Jude Prosser
Publikováno v:
genesis. 41:154-159
Previously published reports have suggested that misexpression of alpha-Synuclein in the Drosophila central nervous system causes neurodegeneration and progressive age-dependent locomotor dysfunction similar to pathologic and clinical manifestations
Publikováno v:
Journal of molecular evolution. 57(3)
The Human Genome Project has provided abundant gene sequence information on human and important model organisms. The chicken is well positioned from an evolutionary standpoint to serve as a link between higher and lower organisms, particularly mammal