Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Vijaya Sambandam"'
Autor:
Gelare Ghajar-Rahimi, Amie M. Traylor, Bini Mathew, James R. Bostwick, N Miranda Nebane, Anna A. Zmijewska, Stephanie K. Esman, Saakshi Thukral, Ling Zhai, Vijaya Sambandam, Rita M. Cowell, Mark J. Suto, James F. George, Corinne E. Augelli-Szafran, Anupam Agarwal
Publikováno v:
Antioxidants, Vol 11, Iss 10, p 1888 (2022)
Acute kidney injury (AKI) is a major public health concern with significant morbidity and mortality and no current treatments beyond supportive care and dialysis. Preclinical studies have suggested that heme-oxygenase-1 (HO-1), an enzyme that catalyz
Externí odkaz:
https://doaj.org/article/25f0f94d8f124a2fac06bb9aa63b0b1c
Autor:
Ruowen Zhang, Jinlu Ma, Justin T. Avery, Vijaya Sambandam, Theresa H. Nguyen, Bo Xu, Mark J. Suto, Rebecca J. Boohaker
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Resistance to radiation and chemotherapy in colorectal cancer (CRC) patients contribute significantly to refractory disease and disease progression. Herein, we provide mechanistic rationale for acquired or inherent chemotherapeutic resistance to the
Externí odkaz:
https://doaj.org/article/00de545de3a84180bfc309628ab6dd67
Autor:
Theresa H Nguyen, Rebecca J. Boohaker, Ruowen Zhang, Mark J. Suto, Bo Xu, Vijaya Sambandam, Justin T. Avery, Jinlu Ma
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Frontiers in Oncology
Frontiers in Oncology
Resistance to radiation and chemotherapy in colorectal cancer (CRC) patients contribute significantly to refractory disease and disease progression. Herein, we provide mechanistic rationale for acquired or inherent chemotherapeutic resistance to the
Publikováno v:
Cancer letters. 434
We report here the rational design and validation of a peptide inhibitor to the PD-1/PD-L1 interaction as an attempt to develop a viable alternative to current inhibitory antibodies. We demonstrated, by biolayer interferometry and in silico docking s
Publikováno v:
Cancer Research. 78:5668-5668
Tumor cells exploit immune checkpoints by expressing checkpoint ligands such as PD-L1, effectively masking them from immune destruction. Programmed cell death- 1 (PD-1), plays a major role in tumor immune escape. The interaction of PD-1/PD-L1 inhibit
Autor:
Kamal N. Tiwari, Vijaya Sambandam, Jaideep V. Thottassery, William B. Parker, Paula W. Allan, Joseph A. Maddry, Melinda G. Hollingshead, Yulia Maxuitenko
Publikováno v:
Cancer chemotherapy and pharmacology. 74(2)
Currently approved DNA hypomethylating nucleosides elicit their effects in part by depleting DNA methyltransferase I (DNMT1). However, their low response rates and adverse effects continue to drive the discovery of newer DNMT1 depleting agents. Herei
Publikováno v:
Infection and Immunity. 68:1441-1449
Porphyromonas gingivalis is considered among the etiological agents of human adult periodontitis. Although in vitro studies have shown that P. gingivalis has the ability to invade epithelial cell lines, its effect on the epithelial barrier junctions
Autor:
Vijaya Sambandam, Daniel F. Balkovetz
Publikováno v:
Kidney International. 56:910-921
Dynamics of E-cadherin and γ-catenin complexes during dedifferentiation of polarized MDCK cells. Background E-cadherin mediated cell-cell adhesion and hepatocyte growth factor (HGF) are important for renal epithelial morphogenesis. We previously sho
Publikováno v:
Biochemical and Molecular Medicine. 62:95-100
Cyclic inositol phosphohydrolase (cIPH), cleaves the cyclic bond of cyclic inositol monophosphate (cIP) to yield inositol monophosphate. In this communication, we demonstrate the presence of cIPH in human urine. cIPH was measured in the 24-h urine sa