Zobrazeno 1 - 10 of 36 pro vyhledávání: '"Vijaya R. Pattabiraman"'
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Abstract 4223: Cis-activation of PD-1+ effector T cells with dual-targeting immunocytokines generated using a novel chemical conjugation platform
Autor: Jean-Philippe Carralot, Matilde Arévalo Ruiz, Robert Tam, Eric Armentani, Vijaya R. Pattabiraman, Bertolt Kreft
Publikováno v: Cancer Research. 82:4223-4223
Immunocytokines (IC) provide the opportunity for targeted delivery of cytokines as payloads to tissues and cells to improve safety and efficacy of cytokine-based therapies. ICs have gained significant interest in recent years and several antibody-cyt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c2b2a398c985deaf63556fb9c6428f1
https://doi.org/10.1158/1538-7445.am2022-4223
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Abstract 2138: Creating next-generation biologics using a novel chemistry platform technology
Autor: Vijaya R. Pattabiraman, Matilde Arévalo Ruiz, Régis Boehringer, Benoit Hornsperger, Roy Meoded, Robert C. Tam, Bertolt Kreft
Publikováno v: Cancer Research. 82:2138-2138
Bright Peak Therapeutics is developing a portfolio of differentiated biotherapeutics using chemistry for applications in immuno-oncology and autoimmune diseases. Our unique chemical protein synthesis and engineering platform allows us to fine-tune cy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a68f4f148747db1ba6e822707eddf2cf
https://doi.org/10.1158/1538-7445.am2022-2138
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Abstract 4224: BPT-143: a fully synthetic alpha-dead IL-2 with a best-in-class preclinical pharmacodynamic and efficacy profile supporting first-in-human clinical development
Autor: Jean-Philippe Carralot, Rubén Alvarez Sanchez, Matilde Arévalo Ruiz, Magali Muller, Vijaya R. Pattabiraman, Bertolt Kreft
Publikováno v: Cancer Research. 82:4224-4224
High-dose recombinant IL-2 (aldesleukin) is approved for treatment of advanced melanoma and renal cell carcinoma, however, major limitations restrict its therapeutic use. Wild-type IL-2 acts via binding to the medium-affinity IL-2 receptor βγ (IL2R
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c528761b5dab2f0b5d7997890b646286
https://doi.org/10.1158/1538-7445.am2022-4224
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Myotubularin-related protein 7 activates peroxisome proliferator-activated receptor-gamma
Autor: Philip Weidner, Daniel Saar, Ariane Nunes-Alves, Elke Burgermeister, Florian Rohrbacher, Jeffrey W. Bode, Laura Helm, Rony Seger, Rebecca C. Wade, Michaela Söhn, Matthias P. Ebert, Tobias Gutting, Johannes Betge, Christoph Röcken, Vijaya R. Pattabiraman, Veronika Hauber, Torsten Schroeder
Publikováno v: Oncogenesis, Vol 9, Iss 6, Pp 1-14 (2020)
Oncogenesis, 9 (6)
Oncogenesis
Peroxisome proliferator-activated receptor-gamma (PPARγ) is a transcription factor drugable by agonists approved for treatment of type 2 diabetes, but also inhibits carcinogenesis and cell proliferation in vivo. Activating mutations in the Kirsten r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::163134aef51b8f5092fb8a246b516ec1
https://doi.org/10.1038/s41389-020-0238-8
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6
Introduction of D-Amino Acids in Minimalistic Peptide Substrates by an S-Adenosyl-L-Methionine Radical Epimerase
Autor: Jeffrey W. Bode, Takefumi Kuranaga, Salome Püntener, Vijaya R. Pattabiraman, Jörn Piel, Anna L. Vagstad
Publikováno v: Angewandte Chemie. International Edition, 58 (8)
Post-translational modifying enzymes from the S-adenosyl-l-methionine (AdoMet) radical superfamily garner attention due to their ability to accomplish challenging biochemical reactions. Among them, a family of AdoMet radical epimerases catalyze irrev
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746ccfb3b10c0b4f7909663c2028f48a
https://hdl.handle.net/20.500.11850/313959
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7
Synthesis of Bifunctional Potassium Acyltrifluoroborates
Autor: Dmitry Mazunin, Vijaya R. Pattabiraman, Sizhou M. Liu, Jeffrey W. Bode
Publikováno v: Organic Letters. 18:5336-5339
New bifunctional potassium acyltrifluoroborate (KAT) substrates have been synthesized in gram scale using optimized reaction conditions. Chemoselective transformation of functional groups in the presence of an acyltrifluoroborate has been demonstrate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f94bd14eb5dabdc30e1e17d485a71a
https://doi.org/10.1021/acs.orglett.6b02652
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Chemical Synthesis of the Highly Hydrophobic Antiviral Membrane-Associated Protein IFITM3 and Modified Variants
Autor: Vijaya R. Pattabiraman, Jeffrey W. Bode, Thibault J. Harmand
Publikováno v: Angewandte Chemie (International Ed. in English)
Angewandte Chemie International Edition
Angewandte Chemie. International Edition, 56 (41)
Angewandte Chemie (Weinheim an Der Bergstrasse, Germany)
Interferon-induced transmembrane protein 3 (IFITM3) is an antiviral transmembrane protein that is thought to serve as the primary factor for inhibiting the replication of a large number of viruses, including West Nile virus, Dengue virus, Ebola virus
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d2cc9d4b51733455c714eb5e72dc64
https://pubmed.ncbi.nlm.nih.gov/28834009
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Bildung und Umlagerung von Homoserin-Depsipeptiden und -proteinen durch α-Ketosäure-Hydroxylamin-Ligation mit 5-Oxaprolin
Autor: Vijaya R. Pattabiraman, Jeffrey W. Bode, Thomas G. Wucherpfennig, Florian Rohrbacher
Publikováno v: Angewandte Chemie. 126:12441-12444
Die Hauptprodukte der chemischen Ligation von α-Ketosauren und 5-Oxaprolin sind Ester und nicht – wie zuvor berichtet – Amide. Durch die schnell ablaufende Umlagerung in basischen Puffern lasst sich das Depsipeptidprodukt in das Amid uberfuhren.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::927a75e5a54e2e07c2886049aae2e347
https://doi.org/10.1002/ange.201406097
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Spurlose Herstellung C-terminaler α-Ketosäuren zur chemischen Proteinsynthese mittels α-Ketoäure-Hydroxylamin-Ligation: Synthese von SUMO2/3
Autor: Felix R. P. Limberg, Thomas G. Wucherpfennig, Javier Ruiz-Rodríguez, Jeffrey W. Bode, Vijaya R. Pattabiraman
Publikováno v: Angewandte Chemie. 126:12445-12449
Eine neue Schutzgruppe fur enantiomerenreine α-Ketosauren ergibt direkt Peptide mit C-terminalen α-Ketosauren bei der Abspaltung von der Festphase und ermoglicht die Gegenwart aller kanonischen Aminosauren im Peptid, einschlieslich Cystein und Meth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37c22bb97f641dd3751aeb9564766b3a
https://doi.org/10.1002/ange.201407014
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