Výsledky vyhledávání - "Vijaya Madhyanapu Golla"

Forced degradation studies on axitinib and characterization of its degradation products by liquid chromatography‐high resolution mass spectrometry and nuclear magnetic resonance spectroscopy along with its in silico toxicity assessment

Autor: Bhoopendra Singh Kushwah, Vijaya Madhyanapu Golla, Vivek Dhiman, Gananadhamu Samanthula

Publikováno v: SEPARATION SCIENCE PLUS. 5:431-441

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d4f2ba7604ee5d6be0fd00c4e4d6f75
https://doi.org/10.1002/sscp.202200043

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Chromatographic separation of tiropramide hydrochloride and its degradation products along with their structural characterization using liquid chromatography quadrupole time‐of‐flight tandem mass spectrometry and nuclear magnetic resonance

Autor: Manik Tidke, Vijaya Madhyanapu Golla, Bhoopendra Singh Kushwah, Dhanavath Dattu Naik, Samanthula Gananadhamu

Publikováno v: Biomedical Chromatography.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::031f0da044fc2d6491b9db68f4d24740
https://doi.org/10.1002/bmc.5636

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Chromatographic separation of tiropramide hydrochloride and its degradation products along with their structural characterization using LC-QTOF-MS/MS and NMR

Autor: Manik Tidke, Vijaya Madhyanapu Golla, Bhoopendra Singh Kushwah, Dhanavath Dattu Naik, Gananadhamu Samanthula

Tiropramide HCl, an antispasmodic drug is subjected to various stress conditions (hydrolytic, oxidative, photolytic and thermal) as per ICH guidelines. The drug is widely used as an antispasmodic agent but there were no comprehensive degradation stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb2964764bc283d2ecf9d0af11c4c160
https://doi.org/10.21203/rs.3.rs-2349648/v1

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LC-HRMS and NMR studies for characterization of forced degradation impurities of ponatinib, a tyrosine kinase inhibitor, insights into in-silico degradation and toxicity profiles

Autor: Vijaya Madhyanapu Golla, Bhoopendra Singh Kushwah, Vivek Dhiman, Laximan Velip, Gananadhamu Samanthula

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 227:115280

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86cd65865902954b763039a3f1c48d3d
https://doi.org/10.1016/j.jpba.2023.115280

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Structural characterization of novel hydrolytic and oxidative degradation products of acalabrutinib by LC-Q-TOF-MS, H/D exchange and NMR

Autor: Bhoopendra Singh, Kushwah, Hara Prasad, Padhy, Rahul, Khemchandani, Vijaya Madhyanapu, Golla, Vinay Kumar, Kanchupalli, Rajesh, Sonti, Gananadhamu, Samanthula

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 221:115077

The drug substance, acalabrutinib was subjected to hydrolytic (acid, base and neutral) and oxidative stress degradation as per ICH recommendations. Degradation products (DPs) generated from the drug substance were separated on a Shimadzu Shim-pak C-8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd4eaabdf9e7502c2578e71f1433cc7
https://doi.org/10.1016/j.jpba.2022.115077

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Identification and characterization of urapidil stress degradation products by LC-Q-TOF-MS and NMR: Toxicity prediction of degradation products

Autor: Laximan, Velip, Vivek, Dhiman, Bhoopendra Singh, Kushwah, Vijaya Madhyanapu, Golla, S, Gananadhamu

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 211:114612

Urapidil, an antihypertensive drug is subjected to various stress conditions (acidic, basic, neutral, oxidative and photolytic) as per ICH guidelines. A stability indicating HPLC method was developed using InertSustain C8 (250 × 4.6 mm; 5 µm) colum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2648d934406228306ddae2c6c53cc6c
https://doi.org/10.1016/j.jpba.2022.114612

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Stress degradation study on entrectinib and characterization of its degradation products using HRMS and NMR

Autor: Vivek Dhiman, Ankit Balhara, Saranjit Singh, Laximan Velip, Gananadhamu Samanthula, Vijaya Madhyanapu Golla, Bhoopendra Singh Kushwah

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 208:114459

Entrectinib is a potent inhibitor of receptor tyrosine kinases and anaplastic lymphoma kinase. It is designated as an orphan drug. There exists no report of comprehensive degradation profiling of the drug in the literature. Therefore, the present stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f453daab4f30599ef4c1d535f0a54f2
https://doi.org/10.1016/j.jpba.2021.114459

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Stability behaviour of antiretroviral drugs and their combinations. 1: characterization of tenofovir disoproxil fumarate degradation products by mass spectrometry

Autor: Vijaya Madhyanapu Golla, Sanjay Kumar, Saranjit Singh, Archana Sahu, Moolchand Kurmi

Publikováno v: RSC Advances. 5:96117-96129

Tenofovir disoproxil fumarate (TDF), an antiretroviral drug, was evaluated for its degradation behaviour in solid and solution states. A total of twelve non-volatile degradation products were formed, which were separated on a C18 column in a gradient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e11ca90fc51727145dd68c1c2c8e06fb
https://doi.org/10.1039/c5ra17532a

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Stability behaviour of antiretroviral drugs and their combinations. 4: Characterization of degradation products of tenofovir alafenamide fumarate and comparison of its degradation and stability behaviour with tenofovir disoproxil fumarate

Autor: Karimullah Shaik, Moolchand Kurmi, Saranjit Singh, Vijaya Madhyanapu Golla

Publikováno v: Journal of pharmaceutical and biomedical analysis. 131

In this study, stress degradation behaviour of tenofovir alafenamide fumarate (TAF), a novel prodrug of tenofovir, was investigated and compared with currently used prodrug congener, tenofovir disoproxil fumarate (TDF), whose intrinsic stability was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a684ca7b9e88a6780505a886d122fa74
https://pubmed.ncbi.nlm.nih.gov/27589032

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