Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Vijaya Karoor"'
Autor:
Vijaya Karoor, Delaney Swindle, David I Pak, Julie Harral, Derek Strassheim, Mehdi A Fini, Edward Dempsey, Kurt R Stenmark, Kathryn Hassell, Rachelle Nuss, Paul W. Buehler, David C. Irwin
Publikováno v:
Pulmonary Circulation, Vol 11, Iss 4, Pp 1-11 (2021)
Macrophages are a heterogeneous population with both pro‐ and anti‐inflammatory functions play an essential role in maintaining tissue homeostasis, promoting inflammation under pathological conditions, and tissue repair after injury. In pulmonary
Externí odkaz:
https://doaj.org/article/120e16e92c14421486d903082b393f81
Autor:
Derek Strassheim, Timothy Sullivan, David C. Irwin, Evgenia Gerasimovskaya, Tim Lahm, Dwight J. Klemm, Edward C. Dempsey, Kurt R. Stenmark, Vijaya Karoor
Publikováno v:
Cells, Vol 10, Iss 12, p 3347 (2021)
G protein-coupled receptors (GPCRs) have originally been described as a family of receptors activated by hormones, neurotransmitters, and other mediators. However, in recent years GPCRs have shown to bind endogenous metabolites, which serve functions
Externí odkaz:
https://doaj.org/article/4cf5369074f34c7fa9694ff0f0312039
Publikováno v:
Journal of Immunology Research, Vol 2019 (2019)
Inflammation is a well-known feature of heart failure. Studies have shown that while some inflammation is required for repair during injury and is protective, prolonged inflammation leads to myocardial remodeling and apoptosis of cardiac myocytes. Va
Externí odkaz:
https://doaj.org/article/1220b3ea826e483fbb5f8f0c83583d9b
Autor:
Derek Strassheim, Vijaya Karoor, Hala Nijmeh, Philip Weston, Martin Lapel, Jerome Schaack, Timothy Sullivan, Edward C. Dempsey, Kurt R. Stenmark, Evgenia Gerasimovskaya
Publikováno v:
Cells, Vol 9, Iss 2, p 416 (2020)
Angiogenic vasa vasorum (VV) expansion plays an essential role in the pathogenesis of hypoxia-induced pulmonary hypertension (PH), a cardiovascular disease. We previously showed that extracellular ATP released under hypoxic conditions is an autocrine
Externí odkaz:
https://doaj.org/article/abc704ecf8194e7ba7592da666e8312c
Autor:
Zoe Loomis, Paul Eigenberger, Katherine Redinius, Christina Lisk, Vijaya Karoor, Eva Nozik-Grayck, Scott K Ferguson, Kathryn Hassell, Rachelle Nuss, Kurt R Stenmark, Paul W Buehler, David C Irwin
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173652 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0171219.].
Externí odkaz:
https://doaj.org/article/159f4039c667483dabd5f002a1d2160d
Autor:
Zoe Loomis, Paul Eigenberger, Katherine Redinius, Christina Lisk, Vijaya Karoor, Eva Nozik-Grayck, Scott K Ferguson, Kathryn Hassell, Rachelle Nuss, Kurt Stenmark, Paul Buehler, David C Irwin
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171219 (2017)
It is now well established that both inherited and acquired forms of hemolytic disease can promote pulmonary vascular disease consequent of free hemoglobin (Hb) induced NO scavenging, elevations in reactive oxygen species and lipid peroxidation. It h
Externí odkaz:
https://doaj.org/article/2f11fa6f21114d7e875df3abc1fd7289
Autor:
Derek Strassheim, Evgenia Gerasimovskaya, David Irwin, Edward C. Dempsey, Kurt Stenmark, Vijaya Karoor
Publikováno v:
Cells, Vol 8, Iss 6, p 551 (2019)
Ras-homologous (Rho)A/Rho-kinase pathway plays an essential role in many cellular functions, including contraction, motility, proliferation, and apoptosis, inflammation, and its excessive activity induces oxidative stress and promotes the development
Externí odkaz:
https://doaj.org/article/541cab3340d84b98b8a95c54060060d4
PDF file - 1.9MB, Mice injected with urethane or MCA/BHT and exposed to normoxia or hypoxia were weighed once a week. Hematocrits were obtained at the end of the experiment. Figure 1 A and B shows body weights in the urethane and MCA/BHT model and an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f6b845c7f603516e9512bfcdbd72860
https://doi.org/10.1158/1940-6207.22525089
https://doi.org/10.1158/1940-6207.22525089
Patients with chronic obstructive pulmonary disease (COPD) are at an increased risk for the development of lung cancer, the mechanisms for which are incompletely understood. We hypothesized that the hypoxic pulmonary microenvironment present in COPD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66ce0521f6c74b66c66ac3017ec39536
https://doi.org/10.1158/1940-6207.c.6544563
https://doi.org/10.1158/1940-6207.c.6544563
PDF file - 2.1MB, Lysates from lungs and tumors obtained from mice treated with urethane and exposed to normoxia or hypoxia were analysed for levels of active and total MAPK (Panels A and B) and expression of pro-survival factors (Panels C and D) by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20921be3b1c43af874f16214898c778e
https://doi.org/10.1158/1940-6207.22525083
https://doi.org/10.1158/1940-6207.22525083