Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Vijaya Gracias"'
Autor:
Peter F. Bousquet, Daniel H. Albert, Gary A. Gintant, Patrick A. Marcotte, Gilbert Diaz, George A. Cunha, Ruth L. Martin, Kathryn Houseman, Stevan W. Djuric, Jürgen Dinges, Jennifer J. Bouska, Thomas J. Sowin, Paul Tapang, Charles W. Hutchins, Michael R. Michaelides, Kimba L. Ashworth, Eric F. Johnson, Henry Q. Zhang, Irini Akritopoulou-Zanze, Michelle Nyein, Arnold Lee D, Hu Li, Steven K. Davidsen, Alan F. Gasiecki, Christopher M. Harris, Vijaya Gracias, Zhi Su, Zhiren Xia
Publikováno v:
Journal of Medicinal Chemistry. 50:2011-2029
The synthesis of a novel series of 1,4-dihydroindeno[1,2-c]pyrazoles with acetylene-type side chains is described. Optimization of those compounds as KDR kinase inhibitors identified 8, which displayed an oral activity in an estradiol-induced murine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7224e585fce7d1645dd21a1f5e3e55
https://doi.org/10.1021/jm061223o
https://doi.org/10.1021/jm061223o
Publikováno v:
Tetrahedron Letters. 47:8873-8876
A concise route to access fused imidazole rings employing the van Leusen three-component reaction followed by a Pd/Cu catalyzed intramolecular C-arylation is reported. The reaction was found to be general and the products were formed in moderate to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5654e6f664aaa720ae0e29145238f37
https://doi.org/10.1016/j.tetlet.2006.10.051
https://doi.org/10.1016/j.tetlet.2006.10.051
Synthesis of fused imidazo-pyridine and -azepine derivatives by sequential van Leusen/Heck reactions
Publikováno v:
Tetrahedron Letters. 47:3225-3228
Fused imidazo-pyridine and -azepine derivatives were synthesized using a sequential van Leusen/intramolecular Heck protocol. The combination of a multicomponent reaction followed by an intramolecular carbon–carbon bond forming reaction generates he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4acfe3de62efbe31324fc26901c87ea5
https://doi.org/10.1016/j.tetlet.2006.03.056
https://doi.org/10.1016/j.tetlet.2006.03.056
Publikováno v:
Tetrahedron Letters. 46:9049-9052
A facile synthesis of fused imidazo azepine derivatives by a van Leusen/intramolecular enyne metathesis synthetic sequence is reported. The two-step reaction sequence generates compounds of significant molecular complexity from simple starting materi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70013c027474aac92f8eef6f6395c3ed
https://doi.org/10.1016/j.tetlet.2005.10.089
https://doi.org/10.1016/j.tetlet.2005.10.089
Publikováno v:
Organic Letters. 7:3183-3186
[reaction: see text]. A new strategy employing the van Leusen three-component reaction and the ring-closing metathesis reaction in a sequential fashion to access fused bicyclic imidazole rings is reported. The two-step sequence generated compounds of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9499de620825fdeb40aaecb04c44292
https://doi.org/10.1021/ol050852+
https://doi.org/10.1021/ol050852+
Publikováno v:
Tetrahedron Letters. 45:417-420
A new strategy employing an Ugi four-component reaction and a microwave-assisted intramolecular Heck cyclization in a sequential fashion to access an array of N-containing heterocycles is reported. The two-step sequence generated compounds of signifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f25d64eff64d94e7b5a10a329bbc0d06
https://doi.org/10.1016/j.tetlet.2003.10.147
https://doi.org/10.1016/j.tetlet.2003.10.147
Autor:
D. Srinivasa Reddy, Kelly Wayne Furness, Jeffrey Aubé, Brenton T. Smith, Vijaya Gracias, Kiran Sahasrabudhe, Christopher E. Katz
Publikováno v:
Journal of the American Chemical Society. 125:7914-7922
An asymmetric equivalent of the Schmidt reaction permits stereocontrol in ring expansions of symmetrical cyclohexanones. The procedure involves the reaction of chiral 1,2- and 1,3-hydroxyalkyl azides with ketones under acid catalysis; the initial rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d496d99fceec2d3861d8e1cf53338b05
https://doi.org/10.1021/ja0348896
https://doi.org/10.1021/ja0348896
Publikováno v:
Tetrahedron Letters. 49:6286-6288
The Ollis–Sweeney ammonium ylid rearrangement has been effectively utilized to provide access to hitherto unknown hybrid privileged structural motifs. The rearrangement of didehydropiperidinium salts containing tethered olefins at the 4-position af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97eefeb32a6ffd49a4c804d57c95e1ca
https://doi.org/10.1016/j.tetlet.2008.08.055
https://doi.org/10.1016/j.tetlet.2008.08.055
Publikováno v:
Tetrahedron. 53:16241-16252
Although alkyl azides can react with ketones to form ring-expanded lactams, the reaction suffers from poor generality and the need to use powerful Lewis acid promotion. The reactions of 1,2- and 1,3-hydroxyalkyl azides with ketones yield N -hydroxyal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e79f7369f96b97f49a428c76f9d4449b
https://doi.org/10.1016/s0040-4020(97)01012-0
https://doi.org/10.1016/s0040-4020(97)01012-0
Publikováno v:
Tetrahedron Letters. 45:8439-8441
We report a facile synthesis of fused dihydrotriazolo[1,5-a]pyrazinones and triazolobenzodiazepines by an Ugi/alkyne–azide cycloaddition synthetic sequence. The coupling of the Ugi multi-component reaction with the intramolecular alkyne–azide cyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61828e2203b80173e3b80a220717308d
https://doi.org/10.1016/j.tetlet.2004.09.117
https://doi.org/10.1016/j.tetlet.2004.09.117