Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Vijay Swahari"'
Autor:
Vijay Swahari, Ayumi Nakamura, Emilie Hollville, Yu-Han Hung, Matt Kanke, C. Lisa Kurtz, Xurde M. Caravia, David Roiz-Valle, Shenghui He, Janakiraman Krishnamurthy, Sahil Kapoor, Varun Prasad, Cornelius Flowers, Matt Beck, Jeanette Baran-Gale, Norman Sharpless, Carlos López-Otín, Praveen Sethupathy, Mohanish Deshmukh
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Aging is a consequence of complex molecular changes, but whether a single microRNA (miRNA) can drive aging remains unclear. A miRNA known to be upregulated during both normal and premature aging is miR-29. We find miR-29 to also be among the
Externí odkaz:
https://doaj.org/article/d2e2c9171b5d43a3bb38718b4bf3ccda
Autor:
Vijay Swahari, Ayumi Nakamura, Emilie Hollville, Hume Stroud, Jeremy M. Simon, Travis S. Ptacek, Matthew V. Beck, Cornelius Flowers, Jiami Guo, Charlotte Plestant, Jie Liang, C. Lisa Kurtz, Matt Kanke, Scott M. Hammond, You-Wen He, E.S. Anton, Praveen Sethupathy, Sheryl S. Moy, Michael E. Greenberg, Mohanish Deshmukh
Publikováno v:
Cell Reports, Vol 35, Iss 1, Pp 108946- (2021)
Summary: Although embryonic brain development and neurodegeneration have received considerable attention, the events that govern postnatal brain maturation are less understood. Here, we identify the miR-29 family to be strikingly induced during the l
Externí odkaz:
https://doaj.org/article/6b13303fc7034e6a9dac5a4c09887e7b
Autor:
Vijay Swahari, Ayumi Nakamura, Jeanette Baran-Gale, Idoia Garcia, Andrew J. Crowther, Robert Sons, Timothy R. Gershon, Scott Hammond, Praveen Sethupathy, Mohanish Deshmukh
Publikováno v:
Cell Reports, Vol 14, Iss 2, Pp 216-224 (2016)
Maintenance of genomic integrity is critical during neurodevelopment, particularly in rapidly dividing cerebellar granule neuronal precursors that experience constitutive replication-associated DNA damage. As Dicer was recently recognized to have an
Externí odkaz:
https://doaj.org/article/13f836ab698c4ab4a62a44214dc9e213
Autor:
Vijay Swahari, Ayumi Nakamura, Emilie Hollville, Yu-Han Hung, Matt Kanke, C. Lisa Kurtz, Xurde M. Caravia, Shenghui He, Janakiraman Krishnamurthy, Sahil Kapoor, Varun Prasad, Cornelius Flowers, Matt Beck, Jeanette Baran-Gale, Norman Sharpless, Carlos López-Otín, Praveen Sethupathy, Mohanish Deshmukh
Aging is a consequence of complex molecular changes, but the roles of individual microRNAs (miRNAs) in aging remain unclear. One of the few miRNAs that are upregulated during both normal and premature aging is miR-29. We confirmed this finding in our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33a994edc9ccecdf3c3cbf15a39b5bbb
https://doi.org/10.1101/2022.11.29.518429
https://doi.org/10.1101/2022.11.29.518429
Autor:
Emilie Hollville, Ayumi Nakamura, Vijay Swahari, Malú G. Tansey, Sheryl S. Moy, Mohanish Deshmukh, Valerie Joers
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Mitochondrial quality control is essential for the long-term survival of postmitotic neurons. The E3 ubiquitin ligase Parkin promotes the degradation of damaged mitochondria via mitophagy and mutations in Parkin are a major cause of early-onset Parki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e462936b40cc99861aa0ead59f4d18fa
http://europepmc.org/articles/PMC7547682
http://europepmc.org/articles/PMC7547682
Autor:
Vijay Swahari, Anne E. West
Publikováno v:
Curr Opin Neurobiol
For more than 40 years after its discovery, histone methylation was thought to be largely irreversible. However, the first histone demethylase (HDM) was identified in 2004, challenging this notion. Since that time, more than 20 HDMs have been identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384736ce9e1528e03e147b55c4fc8dbe
https://pubmed.ncbi.nlm.nih.gov/30878844
https://pubmed.ncbi.nlm.nih.gov/30878844
Autor:
C. Lisa Kurtz, Hume Stroud, Scott M. Hammond, Matthew V. Beck, Charlotte Plestant, Mohanish Deshmukh, Vijay Swahari, Jeremy M. Simon, Cornelius Flowers, E.S. Anton, Praveen Sethupathy, You-Wen He, Travis S. Ptacek, Emilie Hollville, Michael E. Greenberg, Jie Liang, Ayumi Nakamura, Jiami Guo, Matt Kanke, Sheryl S. Moy
Publikováno v:
Cell reports
Cell Reports, Vol 35, Iss 1, Pp 108946-(2021)
Cell Reports, Vol 35, Iss 1, Pp 108946-(2021)
SUMMARY Although embryonic brain development and neurodegeneration have received considerable attention, the events that govern postnatal brain maturation are less understood. Here, we identify the miR-29 family to be strikingly induced during the la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf084d9236c406bedd835f8b6a85741
https://doi.org/10.1016/j.celrep.2021.108946
https://doi.org/10.1016/j.celrep.2021.108946
Autor:
Vijay Swahari, Ayumi Nakamura
Publikováno v:
Development, Growth & Differentiation. 58:116-130
Progeria is a devastating disorder in which patients exhibit signs of premature aging. The most well-known progeroid syndromes include Hutchinson-Gilford Progeria Syndrome (HGPS) and Werner Syndrome (WS). While HGPS and WS are rare, they often result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e468a168e224c483bf575568e4c5478
https://doi.org/10.1111/dgd.12251
https://doi.org/10.1111/dgd.12251
Autor:
Ayumi Nakamura, Ryan P. Annis, Vijay Swahari, Mohanish Deshmukh, Scott M. Hammond, Alison X. Xie
Apoptotic cell death is critical for the early development of the nervous system, but once the nervous system is established, the apoptotic pathway becomes highly restricted in mature neurons. However, the mechanisms underlying this increased resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beac169e9ddcd03c754d0c6fcd7a307b
https://europepmc.org/articles/PMC5438853/
https://europepmc.org/articles/PMC5438853/
Autor:
Spencer L. Smith, Eric S. McCoy, Vijay Swahari, Sheryl S. Moy, Mohanish Deshmukh, Ayumi Nakamura, Charlotte Plestant, Eva S. Anton, Ikuko T. Smith
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 36, iss 20
Apoptosis plays an essential role during brain development, yet the precise mechanism by which this pathway is regulated in the brain remains unknown. In particular, mammalian cells are known to express multiple anti-apoptotic Bcl-2 family proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b5153335038961a94ae9aea88af0019