Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Vijay R Varma"'
Autor:
Vijay R Varma, Youjin Wang, Yang An, Sudhir Varma, Murat Bilgel, Jimit Doshi, Cristina Legido-Quigley, João C Delgado, Anup M Oommen, Jackson A Roberts, Dean F Wong, Christos Davatzikos, Susan M Resnick, Juan C Troncoso, Olga Pletnikova, Richard O'Brien, Eelko Hak, Brenda N Baak, Ruth Pfeiffer, Priyanka Baloni, Siamak Mohmoudiandehkordi, Kwangsik Nho, Rima Kaddurah-Daouk, David A Bennett, Shahinaz M Gadalla, Madhav Thambisetty
Publikováno v:
PLoS Medicine, Vol 18, Iss 5, p e1003615 (2021)
BackgroundWhile Alzheimer disease (AD) and vascular dementia (VaD) may be accelerated by hypercholesterolemia, the mechanisms underlying this association are unclear. We tested whether dysregulation of cholesterol catabolism, through its conversion t
Externí odkaz:
https://doaj.org/article/2c8a7f7dbbcf4006bcc57756f0be9c11
Autor:
Uma V Mahajan, Vijay R Varma, Michael E Griswold, Chad T Blackshear, Yang An, Anup M Oommen, Sudhir Varma, Juan C Troncoso, Olga Pletnikova, Richard O'Brien, Timothy J Hohman, Cristina Legido-Quigley, Madhav Thambisetty
Publikováno v:
PLoS Medicine, Vol 17, Iss 10, p e1003439 (2020)
[This corrects the article DOI: 10.1371/journal.pmed.1003012.].
Externí odkaz:
https://doaj.org/article/c26c92150a414324b984fc7a7fd94c11
Autor:
Uma V Mahajan, Vijay R Varma, Michael E Griswold, Chad T Blackshear, Yang An, Anup M Oommen, Sudhir Varma, Juan C Troncoso, Olga Pletnikova, Richard O'Brien, Timothy J Hohman, Cristina Legido-Quigley, Madhav Thambisetty
Publikováno v:
PLoS Medicine, Vol 17, Iss 1, p e1003012 (2020)
BackgroundThere is growing evidence that Alzheimer disease (AD) is a pervasive metabolic disorder with dysregulation in multiple biochemical pathways underlying its pathogenesis. Understanding how perturbations in metabolism are related to AD is crit
Externí odkaz:
https://doaj.org/article/33544d8fb8e74884a376477c2e37891f
Autor:
Vijay R Varma, Anup M Oommen, Sudhir Varma, Ramon Casanova, Yang An, Ryan M Andrews, Richard O'Brien, Olga Pletnikova, Juan C Troncoso, Jon Toledo, Rebecca Baillie, Matthias Arnold, Gabi Kastenmueller, Kwangsik Nho, P Murali Doraiswamy, Andrew J Saykin, Rima Kaddurah-Daouk, Cristina Legido-Quigley, Madhav Thambisetty
Publikováno v:
PLoS Medicine, Vol 15, Iss 1, p e1002482 (2018)
BACKGROUND:The metabolic basis of Alzheimer disease (AD) is poorly understood, and the relationships between systemic abnormalities in metabolism and AD pathogenesis are unclear. Understanding how global perturbations in metabolism are related to sev
Externí odkaz:
https://doaj.org/article/22f7f44d5e424f9fae92e9cc4533ed09
Autor:
Przemysław R. Kac, Fernando González-Ortiz, Andreja Emeršič, Maciej Dulewicz, Srinivas Koutarapu, Michael Turton, Yang An, Denis Smirnov, Agnieszka Kulczyńska-Przybik, Vijay R. Varma, Nicholas J. Ashton, Laia Montoliu-Gaya, Elena Camporesi, Izabela Winkel, Bogusław Paradowski, Abhay Moghekar, Juan C. Troncoso, Tammaryn Lashley, Gunnar Brinkmalm, Susan M. Resnick, Barbara Mroczko, Hlin Kvartsberg, Milica Gregorič Kramberger, Jörg Hanrieder, Saša Čučnik, Peter Harrison, Henrik Zetterberg, Piotr Lewczuk, Madhav Thambisetty, Uroš Rot, Douglas Galasko, Kaj Blennow, Thomas K. Karikari
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Blood phosphorylated tau (p-tau) biomarkers, including p-tau217, show high associations with Alzheimer’s disease (AD) neuropathologic change and clinical stage. Certain plasma p-tau217 assays recognize tau forms phosphorylated additionally
Externí odkaz:
https://doaj.org/article/cd9a96562fae4bf787bc8b6e650f5603
Autor:
Rahul Ghosal, Vijay R. Varma, Dmitri Volfson, Jacek Urbanek, Jeffrey M. Hausdorff, Amber Watts, Vadim Zipunnikov
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Wearable data is a rich source of information that can provide a deeper understanding of links between human behaviors and human health. Existing modelling approaches use wearable data summarized at subject level via scalar summaries in regr
Externí odkaz:
https://doaj.org/article/926e79661363488c893cdce19765c3ce
Autor:
Vijay R. Varma, Rishi J. Desai, Sheeja Navakkode, Lik-Wei Wong, Carlos Anerillas, Tina Loeffler, Irene Schilcher, Mufaddal Mahesri, Kristyn Chin, Daniel B. Horton, Seoyoung C. Kim, Tobias Gerhard, Jodi B. Segal, Sebastian Schneeweiss, Myriam Gorospe, Sreedharan Sajikumar, Madhav Thambisetty
Publikováno v:
Molecular Psychiatry. 28:1312-1326
We recently nominated cytokine signaling through the Janus-kinase–signal transducer and activator of transcription (JAK/STAT) pathway as a potential AD drug target. As hydroxychloroquine (HCQ) has recently been shown to inactivate STAT3, we hypothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fa84daf8efd2044d43e38d81342535d
https://doi.org/10.1038/s41380-022-01912-0
https://doi.org/10.1038/s41380-022-01912-0
Autor:
Poonam R. Pandey, Vijay R. Varma, Carlos Anerillas, Myriam Gorospe, Allison B. Herman, Jennifer L. Martindale, Dimitrios Tsitsipatis, Martina Rossi, Rachel Munk, Madhav Thambisetty, Jen-Hao Yang, Kotb Abdelmohsen, Jackson A. Roberts
Publikováno v:
Aging (Albany NY)
Cellular senescence is linked to chronic age-related diseases including atherosclerosis, diabetes, and neurodegeneration. Compared to proliferating cells, senescent cells express distinct subsets of proteins. In this study, we used cultured human dip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5af4eef49466e7b3427a4b5b3b37d66
https://doi.org/10.18632/aging.203170
https://doi.org/10.18632/aging.203170
Autor:
Anup M. Oommen, Jackson A. Roberts, Madhav Thambisetty, Olga Pletnikova, Sudhir Varma, Yang An, David A. Bennett, Cristina Legido-Quigley, Chad Blackshear, Juan C. Troncoso, Vijay R. Varma, Richard O'Brien, Tunahan Çakır, H. Büşra Lüleci, Michael Griswold
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-14 (2021)
NPJ Aging and Mechanisms of Disease
NPJ Aging and Mechanisms of Disease
The role of brain cholesterol metabolism in Alzheimer’s disease (AD) remains unclear. Peripheral and brain cholesterol levels are largely independent due to the impermeability of the blood brain barrier (BBB), highlighting the importance of studyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fbb62506b6ed88e04ccb826766cfcc7
https://doaj.org/article/9b5faa98d6754c758ecbe26dd59288c8
https://doaj.org/article/9b5faa98d6754c758ecbe26dd59288c8
Autor:
Kyle D. Moored, Sevil Yasar, Fiona Zabel, Yi-Fang Chuang, Atif Adam, Vijay R. Varma, Michelle C. Carlson
Publikováno v:
J Alzheimers Dis
BACKGROUND: There is emerging evidence about possible involvement of the renin-angiotensin system (RAS) in the pathogenesis of Alzheimer’s disease (AD) and decline of cognitive function. However, little is known about associations with brain biomar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ccdae928bd46ede07ba37deb6789538
https://doi.org/10.3233/jad-200118
https://doi.org/10.3233/jad-200118