Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Vijay Potluri"'
Autor:
Vijay Potluri, Radha K. Shandil, R. Gavara, Ganesh Sambasivam, Brice Campo, Sergio Wittlin, Shridhar Narayanan
Publikováno v:
Malaria Journal, Vol 19, Iss 1, Pp 1-15 (2020)
Abstract Background Emergence of anti-malarial drug resistance and perpetual increase in malaria incidence necessitates the development of novel anti-malarials. Histone deacetylases (HDAC) has been shown to be a promising target for malaria, despite
Externí odkaz:
https://doaj.org/article/b8c41fcfc5a04f1abcd296534d7dba58
Autor:
Amol V. Shivange, Mamatha B. Nijaguna, Gayathri Sadasivam, Vadiraj Kurdekar, Vijay Potluri, Muralidhara Padigaru, Kavitha Bharatham, Jasti Subbarao, Saranya Giridharan, Ashok R. Venkitaraman, Jayaprakash Periasamy, Sanjana Boggaram
Publikováno v:
ChemMedChem. 14:1620-1632
The tandem BRCT domains (tBRCT) of BRCA1 engage phosphoserine-containing motifs in target proteins to propagate intracellular signals initiated by DNA damage, thereby controlling cell cycle arrest and DNA repair. Recently, we identified Bractoppin, t
Autor:
Sergio Wittlin, Shridhar Narayanan, Vijay Potluri, Ganesh Sambasivam, R. Gavara, Radha Shandil, Brice Campo
Publikováno v:
Malaria Journal
Malaria Journal, Vol 19, Iss 1, Pp 1-15 (2020)
Malaria Journal, Vol 19, Iss 1, Pp 1-15 (2020)
Background Emergence of anti-malarial drug resistance and perpetual increase in malaria incidence necessitates the development of novel anti-malarials. Histone deacetylases (HDAC) has been shown to be a promising target for malaria, despite this, the
Autor:
Shruthi Thimmalapura Gangadharaiah, Rajesh Mondal, C N Naveenkumar, Vijaykamal Ahuja, Radha Shandil, Shridhar Narayanan, Prasad Shivarudraiah, Gurdyal S. Besra, Sarah M. Batt, Azger Dusthackeer, Vijay Potluri, Balasubramanian Mahizhaveni, Christy Rosaline Nirmal, Emily J. Richardson, Parvinder Kaur, Sumesh Eswaran, Ramya Vadageri Krishnamurthy, Nicholas J. Loman
Publikováno v:
Tuberculosis. 129:102104
FNDR-20081 [4-{4-[5-(4-Isopropyl-phenyl)- [1,2,4]oxadiazol-3-ylmethyl]-piperazin-1-yl}-7-pyridin-3-yl-quinoline] is a novel, first in class anti-tubercular pre-clinical candidate against sensitive and drug-resistant Mycobacterium tuberculosis (Mtb).
Autor:
Manjunath A. Hurakadli, Jayaprakash Periasamy, Vijay Potluri, Muralidhara Padigaru, Mamatha B. Nijaguna, Sanjana Boggaram, Gayathri Sadasivam, Lokavya Meenakshi Kurup, Ashok R. Venkitaraman, Dhruv Raina, Kavitha Bharatham, Subbarao Jasti, Aneesh Goyal, Vadiraj Kurdekar, Kavyashree Manjunath, Chetan Chintha
Publikováno v:
Cell Chemical Biology
Summary Intracellular signals triggered by DNA breakage flow through proteins containing BRCT (BRCA1 C-terminal) domains. This family, comprising 23 conserved phosphopeptide-binding modules in man, is inaccessible to small-molecule chemical inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::effcfd978ee56cb42cfe6bb6ee159ab4
https://www.repository.cam.ac.uk/handle/1810/278984
https://www.repository.cam.ac.uk/handle/1810/278984
Autor:
Michael Lückmann, Thomas Högberg, Ish Kumar Khanna, K. Pavan Sukumar, Lisbeth Elster, Lakshmi Ramachandran Iyer, Pradip Kumar Sasmal, Chandrasekhar Abbineni, Mahaboobi Jaleel, Khaji Abdul Rawoof, Vijay Potluri, Emima Thadi, Kamal Nijhawan, A. Prasanthi, C. Vamsee Krishna, Thomas M. Frimurer, Øystein Rist, Srisailam Cheera, T. Krishna Chaitanya, K. V. L. Narasimha Rao, S. Sudheerkumar Adabala, M. Roshaiah, N. Lavanya Krishna, Nirbhay Kumar Tiwari
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:887-892
Kappa opioid receptor (KOR) is an important mediator of pain signaling and it is targeted for the treatment of various pains. Pharmacophore based mining of databases led to the identification of 2-aminobenzimidazole derivative as KOR agonists with se
Autor:
Colúm Connolly, Clemens Steegborn, Donald C. Lo, Albena T. Dinkova-Kostova, Andrew Snyder, Vanita Chopra, Alexei Degterev, Michael A. Schwarzschild, Cho Low, Ulrike Träger, Leslie M. Thompson, Michael J. Van Kanegan, James R. Miller, Matthew Fuszard, Ningzhe Zhang, Ellen Sapp, Susanta Samajdar, Lisa Meisel, Kimberly B. Kegel-Gleason, Petr Vodicka, Adelaide Tousley, Lisa M. Ellerby, David Llères, Sébastien Moniot, Aleksey G. Kazantsev, Steven M. Hersch, Lisa A. Crawford, Ross S. Stein, Sarah J. Tabrizi, Eranthie Weerapana, Vijay Potluri, Linda S. Kaltenbach, Ruth Farmer, Blair R. Leavitt, Maureen Higgins, Luisa Quinti, Marian DiFiglia, Sharadha Dayalan Naidu, Xiqun Chen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 23
The activity of the transcription factor nuclear factor-erythroid 2 p45-derived factor 2 (NRF2) is orchestrated and amplified through enhanced transcription of antioxidant and antiinflammatory target genes. The present study has characterized a triaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bba6be10075b3b40875d35cd1e72bd7
https://researchonline.lshtm.ac.uk/id/eprint/3931063/1/KEAP1.pdf
https://researchonline.lshtm.ac.uk/id/eprint/3931063/1/KEAP1.pdf
Publikováno v:
Heterocyclic Communications. 20:207-214
A tandem strategy for the synthesis of 7,12-dihydro-1,3,6,7,12-pentaazapleiadenes and 4-(2-aminophenoxy)pyrido[4,3-d]pyrimidin-5(6H)-ones from readily available starting materials has been developed.
Autor:
Pradip Kumar Sasmal, P. Narasimha Rao, M. Munikumar, Vijay Potluri, Rashmi Talwar, Thammera Ranjith Kumar, Parimal Misra, Menon C. A. Vinu, Seetharaman Sridhar, Chandrasekhar Abbineni, P. Tirumala Rao, Megha Bhattacharya, M. Roshaiah, Poondla. Neelima, Saibal Das, Mahaboobi Jaleel, Khaji Abdul Rawoof, Nutakki Ravi Kumar
Publikováno v:
Letters in Drug Design & Discovery. 11:778-785
Publikováno v:
Tetrahedron Letters. 54:2014-2017
A novel methodology for the synthesis of tetracyclic benzo-pyridonaphthyridines, forming a C–C and a C–N bond in concentrated sulfuric acid at 70 °C in a one-pot is reported. The key substrates (9a–m) are prepared by reacting 2-chloro-6-(4-flu