Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Vijay L. Manthati"'
Autor:
Ramu Errabelli, John R. Falck, Md. Abdul Hye Khan, Vijay L. Manthati, Jan Neckář, John D. Imig, Alexander Staruschenko, Tengis S. Pavlov
Publikováno v:
Hypertension. 62:905-913
Salt-sensitive hypertension leads to kidney injury. The Dahl salt–sensitive hypertensive rat (Dahl SS) is a model of salt-sensitive hypertension and progressive kidney injury. The current set of experimental studies evaluated the kidney protective
Autor:
Uwe Hoff, Cosima Arnold, Erdmann Seeliger, Dominik N. Müller, Maik Gollasch, Bert Flemming, Mechthild Ladwig, Lyubov Chaykovska, Duska Dragun, Ivo Lukitsch, Vijay L. Manthati, Wolf-Hagen Schunck, Friedrich C. Luft, John R. Falck, Wolfgang Schneider, T. Florian Fuller
Publikováno v:
Kidney International. 79:57-65
20-Hydroxyeicosatetraenoic acid (20-HETE) production is increased in ischemic kidney tissue and may contribute to ischemia/reperfusion (I/R) injury by mediating vasoconstriction and inflammation. To test this hypothesis, uninephrectomized male Lewis
Autor:
Daling Zhu, Shanshan Li, Vijay L. Manthati, Weiyang Li, Meetha Medhora, John R. Falck, Elizabeth R. Jacobs, Lei Zhang, Cui Ma, D. Sudarshan Reddy, Shulin Liu, Jun Ma
Publikováno v:
Experimental Cell Research. 316:2340-2353
Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid (AA) catalyzed by cytochrome P450 (CYP), have many essential biologic roles in the cardiovascular system including inhibition of apoptosis in cardiomyocytes. In the present study, we t
Autor:
Ying Gao, Meetha Medhora, Narsimhaswamy Dubasi, Elizabeth R. Jacobs, John R. Falck, Sreedhar Bodiga, Vijay L. Manthati, Stephanie K. Gruenloh
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 298:L564-L574
We have shown that 20-hydroxyeicosatetraenoic acid (20-HETE) increases both superoxide and nitric oxide (NO) production in bovine pulmonary artery endothelial cells (BPAECs). The current study was designed to determine mechanisms underlying 20-HETE-s
Autor:
John R. Falck, Rajkumar Manne, William B. Campbell, Krishnam Raju Atcha, Bruce D. Hammock, Ravinder Kodela, Daniel Goldman, Narsimhaswamy Dubasi, Narender Puli, Christophe Morisseau, Jorge H. Capdevila, Vijay L. Manthati, Xiu Yu Yi
Publikováno v:
Journal of Medicinal Chemistry. 52:5069-5075
All-cis-14,15-epoxyeicosa-5,8,11-trienoic acid (14,15-EET) is a labile, vasodilatory eicosanoid generated from arachidonic acid by cytochrome P450 epoxygenases. A series of robust, partially saturated analogues containing epoxide bioisosteres were sy
Autor:
Wai-Meng Kwok, Vijay L. Manthati, Rong Zhang, John R. Falck, Dexter E. Jacobs, Meetha Medhora, Akihito Tampo, Brandon T. Larsen, David D. Gutterman, Elizabeth R. Jacobs, Darryl C. Zeldin, Sreedhar Bodiga
Publikováno v:
Journal of Molecular and Cellular Cardiology. 46:978-988
Epoxyeicosatrienoic acid(s) (EETs) have been shown to protect cardiovascular tissue against apoptosis dependent on activation of targets such as ATP-sensitive K+ (KATP) channels (sarcolemmal and mitochondrial), calcium-activated K+ channels, extracel
Autor:
John R. Falck, Jing Li, Mairéad A. Carroll, Charles T. Stier, Vijay L. Manthati, Praveen N. Chander
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
Frontiers in Pharmacology
Frontiers in Pharmacology
Kidney damage is markedly accelerated by high-salt (HS) intake in stroke-prone spontaneously hypertensive rats (SHRSP). Epoxyeicosatrienoic acids (EETs) are epoxygenase products of arachidonic acid which possess vasodepressor, natriuretic, and anti-i
Autor:
Demet Unsal, C. Kemal Buharalioglu, Meltem Kacan, Kafait U. Malik, A. Nihal Sari, John R. Falck, Mehmet Sami Serin, Seyhan Şahan Fırat, Belma Korkmaz, Bahar Tunctan, Vijay L. Manthati
We have previously demonstrated that a stable synthetic analog of 20-hydroxyeicosatetraenoic acid (20-HETE), N-(20-hydroxyeicosa-5[Z],14[Z]-dienoyl)glycine (5,14-HEDGE), which mimics the effects of endogenously produced 20-HETE, prevents vascular hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba0f05b1a21c8ea9fbea9cf82c266e25
https://europepmc.org/articles/PMC4158117/
https://europepmc.org/articles/PMC4158117/
Autor:
Samuel Vorin, Guillaume Viault, Frédéric Caijo, Philippe Juin, Florence Manero, Vijay L. Manthati, Danielle Grée, René Grée
Publikováno v:
Tetrahedron Letters. 49:3276-3278
A new and versatile strategy has been developed towards HA 14-1 analogues, selectively modified on position 4 and/or on the primary amine function. An important aspect was the appropriate selection of the phenol protective group in the 5-bromosalicyl
Autor:
Gregory Joseph, Victor Garcia, Frank Zhang, Irina Dimitrova, John R. Falck, Yan Ding, Cheng-Chia Wu, Vijay L. Manthati, Adam Weidenhammer, Jorge H. Capdevila, Michal L. Schwartzman
20-Hydroxyeicosatetraenoic acid (20-HETE) is a cytochrome P-450 (Cyp)-derived arachidonic acid metabolite that has been shown to increase smooth muscle contractions and proliferation, stimulate endothelial dysfunction and activation, and promote hype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dae563d79772337b52c23a24286e82ce
https://europepmc.org/articles/PMC3761206/
https://europepmc.org/articles/PMC3761206/