Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Vijay K. Yechoor"'
Autor:
Julio Aleman, Ravikumar K, Connor Wiegand, Mark E. Schurdak, Lawrence Vernetti, Dillon Gavlock, Celeste Reese, Richard DeBiasio, Greg LaRocca, Yulder Daniel Angarita, Albert Gough, Alejandro Soto-Gutierrez, Jaideep Behari, Vijay K. Yechoor, Mark T. Miedel, Andrew M. Stern, Ipsita Banerjee, D. Lansing Taylor
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Preclinical and clinical studies suggest that lipid-induced hepatic insulin resistance is a primary defect that predisposes to dysfunction in islets, implicating a perturbed liver-pancreas axis underlying the comorbidity of T2DM and MASLD. T
Externí odkaz:
https://doaj.org/article/3786b7dd0e8e47af8bbe42c89dff77b0
Autor:
Young-Hwa Goo, Janeesh Plakkal Ayyappan, Francis D. Cheeran, Sushant Bangru, Pradip K. Saha, Paula Baar, Sabine Schulz, Todd A. Lydic, Bernhard Spengler, Andreas H. Wagner, Auinash Kalsotra, Vijay K. Yechoor, Antoni Paul
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Foam cells in atheroma are engorged with lipid droplets (LDs) that contain esters of regulatory lipids whose metabolism remains poorly understood. LD-associated hydrolase (LDAH) has a lipase structure and high affinity for LDs of foam cells.
Externí odkaz:
https://doaj.org/article/213b8383686e44778bff5f56edd70410
Autor:
Vinny Negi, Jeongkyung Lee, Varun Mandi, Joseph Danvers, Ruya Liu, Eliana M. Perez-Garcia, Feng Li, Rajaganapati Jagannathan, Ping Yang, Domenic Filingeri, Amit Kumar, Ke Ma, Mousumi Moulik, Vijay K. Yechoor
Publikováno v:
Cells, Vol 13, Iss 13, p 1108 (2024)
Cytokine-induced β-cell apoptosis is a major pathogenic mechanism in type 1 diabetes (T1D). Despite significant advances in understanding its underlying mechanisms, few drugs have been translated to protect β-cells in T1D. Epigenetic modulators suc
Externí odkaz:
https://doaj.org/article/4352056514b0436c91865b24cc85dd4b
Autor:
Feng Li, Ruya Liu, Vinny Negi, Ping Yang, Jeongkyung Lee, Rajaganapathi Jagannathan, Mousumi Moulik, Vijay K. Yechoor
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111904- (2023)
Summary: TEAD1 and the mammalian Hippo pathway regulate cellular proliferation and function, though their regulatory function in β cells remains poorly characterized. In this study, we demonstrate that while β cell-specific TEAD1 deletion results i
Externí odkaz:
https://doaj.org/article/58507afec47146c5b6c53a63b91d1ced
Autor:
Despoina Aslanoglou, Suzanne Bertera, Laura Friggeri, Marta Sánchez-Soto, Jeongkyung Lee, Xiangning Xue, Ryan W. Logan, J. Robert Lane, Vijay K. Yechoor, Peter J. McCormick, Jens Meiler, R. Benjamin Free, David R. Sibley, Rita Bottino, Zachary Freyberg
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104771- (2022)
Summary: Bromocriptine is approved as a diabetes therapy, yet its therapeutic mechanisms remain unclear. Though bromocriptine’s actions have been mainly attributed to the stimulation of brain dopamine D2 receptors (D2R), bromocriptine also targets
Externí odkaz:
https://doaj.org/article/073b353a30d149d4b39ba15b63d8a932
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/80a9316234f0489ea6aac13c81dc27be
Autor:
Despoina Aslanoglou, Suzanne Bertera, Marta Sánchez-Soto, R. Benjamin Free, Jeongkyung Lee, Wei Zong, Xiangning Xue, Shristi Shrestha, Marcela Brissova, Ryan W. Logan, Claes B. Wollheim, Massimo Trucco, Vijay K. Yechoor, David R. Sibley, Rita Bottino, Zachary Freyberg
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Dopamine (DA) and norepinephrine (NE) are catecholamines primarily studied in the central nervous system that also act in the pancreas as peripheral regulators of metabolism. Pancreatic catecholamine signaling has also been increasingly impl
Externí odkaz:
https://doaj.org/article/b9206d5d35df46e48ee2e0a5e574828b
Autor:
Daniel E. Lefever, Mark T. Miedel, Fen Pei, Johanna K. DiStefano, Richard Debiasio, Tong Ying Shun, Manush Saydmohammed, Maria Chikina, Lawrence A. Vernetti, Alejandro Soto-Gutierrez, Satdarshan P. Monga, Ramon Bataller, Jaideep Behari, Vijay K. Yechoor, Ivet Bahar, Albert Gough, Andrew M. Stern, D. Lansing Taylor
Publikováno v:
Metabolites, Vol 12, Iss 6, p 528 (2022)
Non-alcoholic fatty liver disease (NAFLD) has a high global prevalence with a heterogeneous and complex pathophysiology that presents barriers to traditional targeted therapeutic approaches. We describe an integrated quantitative systems pharmacology
Externí odkaz:
https://doaj.org/article/465968be7e9348c68b977f1cf547b02f
Autor:
Mariana G. Figueiro, Young‐Hwa Goo, Ryan Hogan, Barbara Plitnick, Jeong‐Kyung Lee, Kiran Jahangir, Mousumi Moulik, Vijay K. Yechoor, Antoni Paul
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 2 (2021)
Background Despite compelling epidemiological evidence that circadian disruption inherent to long‐term shift work enhances atherosclerosis progression and vascular events, the underlying mechanisms remain poorly understood. A challenge to the use o
Externí odkaz:
https://doaj.org/article/d0a4ad155eb8425c8c276b0c296eb5d0
Autor:
Geetali Pradhan, Chia-Shan Wu, Jong Han Lee, Preeti Kanikarla, Shaodong Guo, Vijay K. Yechoor, Susan L. Samson, Yuxiang Sun
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Orexigenic hormone ghrelin and anorexic hormone obestatin are encoded by the same preproghrelin gene. While it is known that ghrelin inhibits glucose-stimulated insulin secretion (GSIS), the effect of obestatin on GSIS is unclear. Ghrelin’
Externí odkaz:
https://doaj.org/article/1b735f08e0564ebead1027bd8a844987