Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Vijay Hegde"'
Publikováno v:
Nutrition & Diabetes, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Objective Obesity, impaired glycemic control, and hepatic steatosis often coexist and are risk factors for developing dementia, and Alzheimer’s disease (AD). We hypothesized that a therapeutic agent that improves glycemic control and steat
Externí odkaz:
https://doaj.org/article/d0b657e397d24e02897307fb66e00964
Publikováno v:
Biology, Vol 12, Iss 7, p 1019 (2023)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by loss of function and eventual death of neurons in the brain. Multiple studies have highlighted the involvement of mitochondria in the initiation and advancement of
Externí odkaz:
https://doaj.org/article/e09b562921234415a72742e03e5ffb05
Autor:
Zahra Mostofinejad, Md Akheruzzaman, Md Abu Bakkar Siddik, Presheet Patkar, Nikhil V Dhurandhar, Vijay Hegde
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 9, Iss 1 (2021)
Introduction Older age is associated with greater prevalence of hyperinsulinemia, type 2 diabetes, and fatty liver disease. These metabolic conditions and aging are bidirectionally linked to mitochondrial dysfunction and telomere attrition. Although
Externí odkaz:
https://doaj.org/article/40923baac7264948a31d25b4378260b0
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
In recent years, several studies have suggested that cardiometabolic disorders, such as diabetes, obesity, hypertension, and dyslipidemia, share strong connections with the onset of neurodegenerative disorders such as Parkinson’s and Alzheimer’s
Externí odkaz:
https://doaj.org/article/bac1adac5b484ac48331af9b8c606a39
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9286 (2022)
Non-alcoholic fatty liver disease (NAFLD) covers a broad spectrum of liver diseases ranging from steatosis to cirrhosis. There are limited data on prevention of hepatic steatosis or its progression to liver disease. Here, we tested if either transgen
Externí odkaz:
https://doaj.org/article/4321c73ccff94ffc9e8e437ceea31187
Publikováno v:
Adipocyte, Vol 8, Iss 1, Pp 240-253 (2019)
Adipose tissue expansion involves angiogenesis to remodel its capillary network. The enzymemethionine aminopeptidase 2(MetAP2) promotes angiogenesis.MetAP2 inhibitors suppress angiogenesis and have potential anti-obesity effect. However, impairment i
Externí odkaz:
https://doaj.org/article/4e423ed13fc748fc999d4a83c087a79e
Autor:
Bhagavathi Ramasubramanian, Cameron Griffith, Madison Hanson, Lloyd E. Bunquin, Arubala P. Reddy, Vijay Hegde, P. Hemachandra Reddy
Publikováno v:
Cells, Vol 11, Iss 4, p 744 (2022)
The purpose of our study is to determine the protective effects of the chaya leaf against mitochondrial abnormalities and synaptic damage in the Type 2 diabetes (T2D) mouse model, TallyHO (TH). The TH mouse is a naturally occurring polygenic mouse mo
Externí odkaz:
https://doaj.org/article/fac360c388754f61bf9b555ccb3df7e4
Publikováno v:
Heliyon, Vol 6, Iss 10, Pp e05261- (2020)
Obesity and hyperlipidemia are independent risk factors of chronic kidney disease (CKD). In mice, diet induced obesity accelerates lipogenesis, lipid accumulation, and injury in kidneys. Expression of adenoviral protein, E4orf1, improves glucose clea
Externí odkaz:
https://doaj.org/article/acbd9bbcb5384fbda40f35dbc61491d8
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208427 (2018)
BackgroundType 2 diabetes is often linked with impaired proximal insulin signaling. Hence, a therapeutic agent that enhances cellular glucose uptake without requiring proximal insulin signaling would be desirable for improving glycemic control. The E
Externí odkaz:
https://doaj.org/article/ff6caa1cf3ab4b00a8a969b3b49280e2
Autor:
Christine M. Kusminski, Violeta I. Gallardo-Montejano, Zhao V. Wang, Vijay Hegde, Perry E. Bickel, Nikhil V. Dhurandhar, Philipp E. Scherer
Publikováno v:
Molecular Metabolism, Vol 4, Iss 10, Pp 653-664 (2015)
Background/Purpose: Type 2 diabetes remains a worldwide epidemic with major pathophysiological changes as a result of chronic insulin resistance. Insulin regulates numerous biochemical pathways related to carbohydrate and lipid metabolism. Methods: W
Externí odkaz:
https://doaj.org/article/a25de384990b4923aeeef6d3887d9fb0