Nuclear Receptors: Opening Up New Avenues of Pediatric Fatty Liver Research

Autor: Vijay Pandyarajan, Ekihiro Seki

Publikováno v: Hepatology Communications, Vol 2, Iss 10, Pp 1157-1159 (2018)

Externí odkaz: https://doaj.org/article/560af9ed5d244401aca7c0e40ffb3fa5

Contribution of TyrB26 to the Function and Stability of Insulin

Autor: Michael C. Lawrence, Nischay K. Rege, Jonathan Whittaker, Vijay Pandyarajan, Nelson B. Phillips, Michael A. Weiss

Publikováno v: Journal of Biological Chemistry. 291:12978-12990

Crystallographic studies of insulin bound to receptor domains have defined the primary hormone-receptor interface. We investigated the role of TyrB26, a conserved aromatic residue at this interface. To probe the evolutionary basis for such conservati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f5acbe13b74dfb509cc3ff0caf2512a
https://doi.org/10.1074/jbc.m115.708347

Aromatic Anchor at an Invariant Hormone-Receptor Interface

Autor: Jonathan Whittaker, Gabriella P. Cox, Nalinda P. Wickramasinghe, Michael A. Weiss, Brian J. Smith, John G. Menting, Faramarz Ismail-Beigi, Linda Whittaker, Vijay Pandyarajan, Zhuli Wan, Nelson B. Phillips, Michael C. Lawrence

Publikováno v: Journal of Biological Chemistry. 289:34709-34727

Crystallographic studies of insulin bound to fragments of the insulin receptor have recently defined the topography of the primary hormone-receptor interface. Here, we have investigated the role of PheB24, an invariant aromatic anchor at this interfa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b030c58a50c6cdb5cdea3108dec82b5e
https://doi.org/10.1074/jbc.m114.608562

Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY

Autor: Krystel El Hage, Nelson B. Phillips, Brian J. Smith, Michael A. Weiss, Vijay Pandyarajan, Markus Meuwly, Michael C. Lawrence, John G. Menting, Jonathan Whittaker

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (53), pp.27023-27041. ⟨10.1074/jbc.M116.761015⟩

International audience; Insulin, a protein critical for metabolic homeostasis, provides a classical model for protein design with application to human health. Recent efforts to improve its pharmaceutical formulation demonstrated that iodination of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13c26c8774515dd40e5a5d24618f3bc
https://hal-univ-evry.archives-ouvertes.fr/hal-02160383

Non-Standard Protein Engineering at the Boundary of Molecular Mechanics and Quantum Chemistry: Halogen-Based Design of Insulin Analogs

Autor: Yen-Shan Chen, Yanwu Yang, Nalinda P. Wickramasinghe, Faramarz Ismail-Beigi, Michael A. Weiss, Markus Meuwly, Michael C. Lawrence, Vijay Pandyarajan, Krystel El-Hage, Brian J. Smith, John G. Menting, Nelson F. Phillips

Publikováno v: Biophysical Journal. 112:53a

The broad utility of halogens in medicinal chemistry has motivated application of hybrid quantum- and molecular-mechanical methods. Extending these concepts to a therapeutic protein (insulin), iodination of a conserved tyrosine at position B26 was re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05527fd4f8d63637ce6428a6d1c16d60
https://doi.org/10.1016/j.bpj.2016.11.323