Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Vijay, Chhajlani"'
Autor:
Aakshi Kalra, Debadutta Parija, Neeraj Raizada, K S Sachdeva, Raghuram Rao, Soumya Swaminathan, Ashwani Khanna, Kamal Kishore Chopra, M Hanif, Varinder Singh, K R Umadevi, K N Sheladia, Rama Rao, N Vasundhara, Anil S, Nirmala A R, Abdul Azeem, Vijay Chhajlani, Jyoti Khurana, N J Das, Bandana Choudhury, Sreenivas Achuthan Nair, Shalini Mall, Rajashree Sen, Sarabjit Singh Chadha, Claudia M Denkinger, Catharina Boehme, Sanjay Sarin
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0236057 (2020)
BackgroundDiagnosis of TB in pediatric population poses several challenges. A novel initiative was implemented in several major cities of India aimed at providing upfront access to free-of-cost Xpert MTB/RIF to presumptive pediatric TB cases. This pa
Externí odkaz:
https://doaj.org/article/5b3c5190a6c14db4a52c519678ef8528
Autor:
Sarabjit Chadha, Catharina Boehme, K. N. Sheladia, Shalini Mall, K. R. Umadevi, Aakshi Kalra, Vijay Chhajlani, Rama Rao, Debadutta Parija, Jyoti Khurana, Neeraj Raizada, Narayan Das, Varinder Singh, A R Nirmala, K K Chopra, M. Hanif, S Anil, N. Vasundhara, Sanjay Sarin, Abdul Azeem, Soumya Swaminathan, Rajashree Sen, Sreenivas Achuthan Nair, Ashwani Khanna, B. U. Choudhury, Claudia M. Denkinger, Kuldeep Singh Sachdeva, Raghuram Rao
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0236057 (2020)
PLoS ONE
PLoS ONE
BackgroundDiagnosis of TB in pediatric population poses several challenges. A novel initiative was implemented in several major cities of India aimed at providing upfront access to free-of-cost Xpert MTB/RIF to presumptive pediatric TB cases. This pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::756e336971542940d508b7890ba1e742
https://doaj.org/article/5b3c5190a6c14db4a52c519678ef8528
https://doaj.org/article/5b3c5190a6c14db4a52c519678ef8528
Autor:
Donna L. Maier, Smita V. Ghanekar, Charles S. Elmore, Chi-Ming Lee, Min Ding, Jennifer L. Werkheiser, John R. Zysk, Vijay Chhajlani, Jianwei Liu
Publikováno v:
Synapse. 66:315-322
Neuronal nicotinic acetylcholine receptor (nAChR) agonists active at the alpha-7 (α-7) receptor subtype are potential therapeutics for cognitive deficits in schizophrenia, Alzheimer's disease, and other mental disorders. SSR180711, an α-7 selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ccedb9b957284923802ac9c174f5d27
https://doi.org/10.1002/syn.21513
https://doi.org/10.1002/syn.21513
Autor:
Patricia Schroeder, Jalaj Arora, Kim L. Zeller, Reto Gadient, Minli Zhang, Jeffrey S. Smith, Nathan Spear, Vijay Chhajlani, Deidre E. Wilkins, Mylinh Do
Publikováno v:
European Journal of Pharmacology. 659:146-154
Recent reports have indicated that patients with schizophrenia have a profound hypo-functionality of glutamatergic signaling pathways. Positive allosteric modulation of mGlu(5) receptor has been postulated to augment NMDA function and thereby allevia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070ccb46b7ab7d2b25c844a5605d6845
https://doi.org/10.1016/j.ejphar.2011.02.003
https://doi.org/10.1016/j.ejphar.2011.02.003
Autor:
Michael Balestra, Francis M. McLaren, Julie Wilson, Linda A. Sygowski, Nathan Spear, James Kang, John P. McCauley, Lindsay Hinkley, Becky Brockel, Laura M. Panko, Valerie Hoesch, James Woods, Jalaj Arora, Kelly Brush, Minli Zhang, Thomas R. Simpson, Caprice Hightower, Dean G. Brown, Todd Andrew Brugel, Megan M. King, Abdelmalik Slassi, Vijay Chhajlani, Reed W. Smith, Gerard M. Koether, Reto Gadient, Hui Xiong, Methvin Isaac, Nathalie Breysse
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7381-7384
Positive allosteric modulation of metabotropic glutamate receptor 5 (mGluR5) is regarded as a potential novel treatment for schizophrenic patients. Herein we report the synthesis and SAR of 4-aryl piperazine and piperidine amides as potent mGluR5 pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5646a25d7e6c272143c3c4c91c7174
https://doi.org/10.1016/j.bmcl.2010.10.036
https://doi.org/10.1016/j.bmcl.2010.10.036
Autor:
Lars Swanson, Magnus Johansson, Asa Rosenquist, Graeme Semple, Jennie Georgsson, Vijay Chhajlani, Britt Marie Andersson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1141-1145
New analogues of the previously described 3-aryl pyridone KOR agonists have been synthesised by parallel synthetic methods, both in solution- and with solid-phase chemistry, making use of the well known and versatile Mitsunobu, Suzuki and Buchwald re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31f889c28d9b12c9e4627062519700fd
https://doi.org/10.1016/s0960-894x(03)00033-7
https://doi.org/10.1016/s0960-894x(03)00033-7
Autor:
Henrik Toft Sørensen, Jennie Georgsson, Asa Rosenquist, Fritof Pontén, Britt-Marie Andersson, Vijay Chhajlani, Lars Swanson, Magnus Johansson, Marianne Swanson, Graeme Semple, Marcel Lindschoten
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:197-200
A new series of 3-aryl pyridone based kappa opioid receptor agonists was designed and synthesised, based on an understanding of the classical kappa opioid receptor pharmacophore. The most potent of the new compounds were comparable to U-69,593 in rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e52070d390d2353cb0fa9cc19b59d76
https://doi.org/10.1016/s0960-894x(01)00691-6
https://doi.org/10.1016/s0960-894x(01)00691-6
Publikováno v:
IUBMB Life. 46:913-922
To delineate domains essential for G-protein coupling in melanocortin 1 receptor (MC1R), we mutated polar and basic residues to alanine at eleven positions in the putative third intracellular loop and determined consequent changes in the ligand bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097c152f0abdf4c429dc1d6c0f341f4d
https://doi.org/10.1080/15216549800204462
https://doi.org/10.1080/15216549800204462
Publikováno v:
Biochemical and Biophysical Research Communications. 236:489-492
The human melanocortin 5 receptor (hMC5R) in the melanocortin receptor family has been identified as the receptor with low affinity towards alpha-MSH. Here we show that the glutamine at position 235 and arginine at the position 272 in the hMC5R are c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7066d24ab7a058de1fb88f64918a23
https://doi.org/10.1006/bbrc.1997.6994
https://doi.org/10.1006/bbrc.1997.6994
Publikováno v:
Biochemical and Biophysical Research Communications. 219:521-525
To investigate whether residues in the extracellular domains of melanocortin 1 receptor (MC1R) are required for ligand binding, a number of mutants were constructed where charged residues were converted to alanine. The residues targeted for mutagenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::617fe466d301e063f1630658bf9febd4
https://doi.org/10.1006/bbrc.1996.0266
https://doi.org/10.1006/bbrc.1996.0266