Metabolism of hyperpolarised [1– 13 C]pyruvate in awake and anaesthetised rat brains

Autor: Petteri Stenroos, Jaakko Paasonen, Olli Gröhn, Viivi Hyppönen, Riikka Nivajärvi, Mikko I. Kettunen, Jan Henrik Ardenkjær-Larsen

Publikováno v: NMR in Biomedicine. 35

The use of hyperpolarised 13 C pyruvate for nononcological neurological applications has not been widespread so far, possibly due to delivery issues limiting the visibility of metabolites. First proof-of-concept results have indicated that metabolism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c0579ecbf56d1098f35c635dcc2f517
https://doi.org/10.1002/nbm.4635

Detection of lentiviral suicide gene therapy in C6 rat glioma using hyperpolarised [1-13C]pyruvate

Autor: Olli Gröhn, Hanna Leinonen, Sean Bowen, Jan Henrik Ardenkjær-Larsen, Venla Olsson, Viivi Hyppönen, Seppo Ylä-Herttuala, Riikka Nivajärvi, Mikko I. Kettunen, Hanna P. Lesch

Publikováno v: Nivajärvi, R, Olsson, V, Hyppönen, V, Bowen, S, Leinonen, H M, Lesch, H P, Ardenkjær-Larsen, J H, Gröhn, O H J, Ylä-Herttuala, S & Kettunen, M I 2020, ' Detection of lentiviral suicide gene therapy in C6 rat glioma using hyperpolarised [1-13 C]pyruvate ', NMR in Biomedicine, vol. 33, no. 4, e4250 . https://doi.org/10.1002/nbm.4250

Hyperpolarised [1-13C]pyruvate MRI has shown promise in monitoring therapeutic efficacy in a number of cancers including glioma. In this study, we assessed the pyruvate response to the lentiviral suicide gene therapy of herpes simplex virus-1 thymidi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a902138447e73273cae520b862d1427
https://orbit.dtu.dk/en/publications/2fc8d8d4-046e-4841-a458-1482f7f3e95a