Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Viia E. Valge-Archer"'
Autor:
Suzanne I. Sitnikova, Jennifer A. Walker, Laura B. Prickett, Michelle Morrow, Viia E. Valge-Archer, Matthew J. Robinson, Robert W. Wilkinson, Simon J. Dovedi
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionImmuno-oncology (IO) research relies heavily on murine syngeneic tumor models. However, whilst the average age for a cancer diagnosis is 60 years or older, for practical purposes the majority of preclinical studies are conducted in young
Externí odkaz:
https://doaj.org/article/1b4f24a133924f28b0538a31b1ac7be8
Autor:
Wael Traboulsi, Subhadip Kundu, Pankaj Gaur, Zainab Ramlaoui, Dareen Sarhan, Nour Shobaki, Jacob Lee, Nazli Jafarzadeh, Simon T. Barry, Viia E. Valge-Archer, Vivek Verma, Seema Gupta, Samir N. Khleif
Publikováno v:
Cancer Research. 83:LB339-LB339
Olaparib is the most widely studied third-generation PARP inhibitor (PARPi) in clinical practice with a significant clinical outcome in BRCA deficient tumors such as breast and ovarian cancers. However, innate and adaptive resistance in patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d74ccffc53ef1961329e9c7e474a468
https://doi.org/10.1158/1538-7445.am2023-lb339
https://doi.org/10.1158/1538-7445.am2023-lb339
Autor:
Pankaj Gaur, Vivek Verma, Mays Alreem Elayyan, Zainab Ramlaoui, Simon T. Barry, Viia E. Valge-Archer, Paul D. Smith, Seema Gupta, Samir N. Khleif
Publikováno v:
Cancer Research. 82:4217-4217
In the tumor microenvironment (TME), T cell exhaustion and short persistence of effector cells are crucial factors that limit the efficacy of endogenously generated or adoptively transferred effector cells. Regenerative stem-cell memory CD62LhiCD44lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8577836882e235b346446852f9fb29d9
https://doi.org/10.1158/1538-7445.am2022-4217
https://doi.org/10.1158/1538-7445.am2022-4217
Publikováno v:
Nature Reviews Drug Discovery. 6:349-356
Monoclonal antibodies are now established as a key therapeutic modality for a range of diseases. Owing to the ability of these agents to selectively target tumour cells, cancer has been a major focus of development programmes for monoclonal antibodie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3d93a0486926d1b00f3f9d18521bb8
https://doi.org/10.1038/nrd2241
https://doi.org/10.1038/nrd2241
Publikováno v:
Nucleic Acids Research. 22:2134-2142
We have investigated the characteristics of IL2R alpha gene induction in untransformed murine T cells. Induction of IL2R alpha mRNA by TCR/CD3 ligands in a murine T cell clone and in short-term splenic T cell cultures was inhibited by protein synthes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d36419a3aead6eed6270905a39ed84c
https://doi.org/10.1093/nar/22.11.2134
https://doi.org/10.1093/nar/22.11.2134
Publikováno v:
Nature. 356:801-804
The nuclear factor NF-AT (ref. 1) is induced in T cells stimulated through the T-cell receptor/CD3 complex, and is required for interleukin-2 (IL-2) gene induction. Although NF-AT has not been cloned or purified, there is evidence that it is a major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85492a4a1ae1ed568490d0708bf6152
https://doi.org/10.1038/356801a0
https://doi.org/10.1038/356801a0
Publikováno v:
The Journal of Experimental Medicine
Stimulation of T cells with antigen results in activation of several kinases, including protein kinase C (PKC), that may mediate the later induction of activation-related genes. We have examined the potential role of PKC in induction of the interleuk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80b98ea412a1feff736dfe66220bb253
https://pubmed.ncbi.nlm.nih.gov/1740667
https://pubmed.ncbi.nlm.nih.gov/1740667