Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Vignir Helgason"'
Autor:
Martha M. Zarou, Kevin M. Rattigan, Daniele Sarnello, Engy Shokry, Amy Dawson, Angela Ianniciello, Karen Dunn, Mhairi Copland, David Sumpton, Alexei Vazquez, G. Vignir Helgason
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Supporting cell proliferation through nucleotide biosynthesis is an essential requirement for cancer cells. Hence, inhibition of folate-mediated one carbon (1C) metabolism, which is required for nucleotide synthesis, has been successfully ex
Externí odkaz:
https://doaj.org/article/6aaf61afdaf341b3a2d9f753c4561387
Autor:
Amy Dawson, Martha M. Zarou, Bodhayan Prasad, Joana Bittencourt-Silvestre, Désirée Zerbst, Ekaterini Himonas, Ya-Ching Hsieh, Isabel van Loon, Giovanny Rodriguez Blanco, Angela Ianniciello, Zsombor Kerekes, Vaidehi Krishnan, Puneet Agarwal, Hassan Almasoudi, Laura McCluskey, Lisa E. M. Hopcroft, Mary T. Scott, Pablo Baquero, Karen Dunn, David Vetrie, Mhairi Copland, Ravi Bhatia, Seth B. Coffelt, Ong Sin Tiong, Helen Wheadon, Sara Zanivan, Kristina Kirschner, G. Vignir Helgason
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Macrophages are fundamental cells of the innate immune system that support normal haematopoiesis and play roles in both anti-cancer immunity and tumour progression. Here we use a chimeric mouse model of chronic myeloid leukaemia (CML) and hu
Externí odkaz:
https://doaj.org/article/8f93c354e91945c2be6407a9da014cb7
Autor:
Kevin M. Rattigan, Zuzana Brabcova, Daniele Sarnello, Martha M. Zarou, Kiron Roy, Ryan Kwan, Lucie de Beauchamp, Amy Dawson, Angela Ianniciello, Ahmed Khalaf, Eric R. Kalkman, Mary T. Scott, Karen Dunn, David Sumpton, Alison M. Michie, Mhairi Copland, Saverio Tardito, Eyal Gottlieb, G. Vignir Helgason
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Deregulated oxidative metabolism is a hallmark of leukaemia. While tyrosine kinase inhibitors (TKIs) such as imatinib have increased survival of chronic myeloid leukaemia (CML) patients, they fail to eradicate disease-initiating leukemic ste
Externí odkaz:
https://doaj.org/article/f6923fc9708841a5bf7e890a6863e86a
Autor:
Keith Woodley, Laura S. Dillingh, George Giotopoulos, Pedro Madrigal, Kevin M. Rattigan, Céline Philippe, Vilma Dembitz, Aoife M. S. Magee, Ryan Asby, Louie N. van de Lagemaat, Christopher Mapperley, Sophie C. James, Jochen H. M. Prehn, Konstantinos Tzelepis, Kevin Rouault-Pierre, George S. Vassiliou, Kamil R. Kranc, G. Vignir Helgason, Brian J. P. Huntly, Paolo Gallipoli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Resistance to standard and novel therapies remains the main obstacle to cure in acute myeloid leukaemia (AML) and is often driven by metabolic adaptations which are therapeutically actionable. Here we identify inhibition of mannose-6-phospha
Externí odkaz:
https://doaj.org/article/a02c0de22e004847b729037f65f8b163
Autor:
Narissa Parry, Caroline Busch, Victoria Aßmann, Jennifer Cassels, Alan Hair, G. Vignir Helgason, Helen Wheadon, Mhairi Copland
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract Dysregulation of the BCL-2 family is implicated in protecting chronic myeloid leukemia (CML) cells from intracellular damage and BCR::ABL1-inhibition with tyrosine kinase inhibitors (TKIs) and may be a viable therapeutic target in blast phas
Externí odkaz:
https://doaj.org/article/c29e35dfaaa141d8b99d7b68e062919f
Publikováno v:
HemaSphere, Vol 7, Iss 6, p e895 (2023)
Specific cell types and, therefore, organs respond differently during aging. This is also true for the hematopoietic system, where it has been demonstrated that hematopoietic stem cells alter a variety of features, such as their metabolism, and accum
Externí odkaz:
https://doaj.org/article/ece8563d7d63485cbb60d7012f8f5b32
Autor:
Sonja Loges, Tessa L. Holyoake, G. Vignir Helgason, Carsten Bokemeyer, Klaus Pantel, Andreas Hochhaus, Peter Carmeliet, Tim H. Brümmendorf, Peter Vandenberghe, Subir Mitra, Alexander Schultze, Steffen Koschmieder, Richard E. Clark, Stephen Rankin, Janna L. Velthaus, Philippe Schafhausen, Gunhild von Amsberg, Thomas Ernst, Rebecca Mitchell, Heather Jørgensen, Robert Erdmann, Isabel Ben-Batalla
Purpose: BCR-ABL kinase inhibitors are employed successfully for chronic myeloid leukemia (CML) treatment. However, resistant disease and persistence of BCR-ABL1–independent leukemia stem and progenitor cells (LSPC) remain clinical challenges. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4c9f65def4c57a65d58ae92abc93d8
https://doi.org/10.1158/1078-0432.c.6525134.v1
https://doi.org/10.1158/1078-0432.c.6525134.v1
Autor:
Sonja Loges, Tessa L. Holyoake, G. Vignir Helgason, Carsten Bokemeyer, Klaus Pantel, Andreas Hochhaus, Peter Carmeliet, Tim H. Brümmendorf, Peter Vandenberghe, Subir Mitra, Alexander Schultze, Steffen Koschmieder, Richard E. Clark, Stephen Rankin, Janna L. Velthaus, Philippe Schafhausen, Gunhild von Amsberg, Thomas Ernst, Rebecca Mitchell, Heather Jørgensen, Robert Erdmann, Isabel Ben-Batalla
Figure S1. Inhibition of Axl by shRNA. Figure S2. Assessment of half maximal inhibitory concentration (IC50) for BGB324 in human CD34+ cells from healthy donors. Figure S3. Treatment with BGB324 increased apoptosis and decreased proliferation of CML
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5afe9081732bbaa5bc72c766273976ad
https://doi.org/10.1158/1078-0432.22462538
https://doi.org/10.1158/1078-0432.22462538
Supplementary Figure 2 from Oncogene-Induced Sensitization to Chemotherapy-Induced Death Requires Induction as well as Deregulation of E2F1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e35bae8cdc4e8e182e225a9cb5e4efc
https://doi.org/10.1158/0008-5472.22383501
https://doi.org/10.1158/0008-5472.22383501
The analysis of DNA tumor viruses has provided landmark insights into the molecular pathogenesis of cancer. A paradigm for this field has been the study of the adenoviral E1a protein, which has led to the identification of proteins such as p300, p400
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cc59f017b9df5efbffe61e641aa68e5
https://doi.org/10.1158/0008-5472.c.6500562
https://doi.org/10.1158/0008-5472.c.6500562