Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Vignesh, Jayarajan"'
Autor:
Alice Burleigh, Elena Moraitis, Eman Al Masroori, Eslam Al-Abadi, Ying Hong, Ebun Omoyinmi, Hannah Titheradge, Karen Stals, Wendy D. Jones, Anthony Gait, Vignesh Jayarajan, Wei-Li Di, Neil Sebire, Lea Solman, Malobi Ogboli, Steven B. Welch, Annapurna Sudarsanam, Ian Wacogne, Fiona Price-Kuehne, Barbara Jensen, Paul A. Brogan, Despina Eleftheriou
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
ISG15 deficiency is a rare disease caused by autosomal recessive variants in the ISG15 gene, which encodes the ISG15 protein. The ISG15 protein plays a dual role in both the type I and II interferon (IFN) immune pathways. Extracellularly, the ISG15 p
Externí odkaz:
https://doaj.org/article/c36d89f5574143d294b7edb06389dfd6
Autor:
Gaetano Naso, Soragia Athina Gkazi, Christos Georgiadis, Vignesh Jayarajan, Joanna Jacków, Roland Fleck, Leanne Allison, Olumide Kayode Ogunbiyi, John Alexander McGrath, Dusko Ilic, Wei-Li Di, Anastasia Petrova, Waseem Qasim
Publikováno v:
JID Innovations, Vol 3, Iss 3, Pp 100191- (2023)
Recessive dystrophic epidermolysis bullosa is a debilitating blistering skin disorder caused by loss-of-function mutations in COL7A1, which encodes type VII collagen, the main component of anchoring fibrils at the dermal−epidermal junction. Althoug
Externí odkaz:
https://doaj.org/article/9263ccbe4af242a788d4bbea877e0263
Autor:
Vignesh Jayarajan, George T. Hall, Theodoros Xenakis, Neil Bulstrode, Dale Moulding, Sergi Castellano, Wei-Li Di
Publikováno v:
Cells, Vol 12, Iss 3, p 346 (2023)
Primary keratinocytes including keratinocyte stem cells (KSCs) can be cultured as epidermal sheets in vitro and are attractive for cell and gene therapies for genetic skin disorders. However, the initial slow growth of freshly isolated keratinocytes
Externí odkaz:
https://doaj.org/article/0305322fe49c4ab8a545bf67ed65af03
Autor:
Vignesh Jayarajan, George T. Hall, Theodoros Xenakis, Neil Bulstrode, Dale Moulding, Sergi Castellano, Wei-Li Di
Somatic stem cells can be cultured in-vitro and are attractive for cell and gene therapies, but their slow growth in in-vitro culture affects survival and stemness and hinders clinical applications. Rho-associated kinase inhibitor (ROCKi) has been us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::995341024f54d6136e04736f21232ce3
https://doi.org/10.1101/2022.06.28.497914
https://doi.org/10.1101/2022.06.28.497914
Publikováno v:
Experimental Dermatology
Genetic skin diseases, also known as genodermatoses, are inherited disorders affecting skin and constitute a large and heterogeneous group of diseases. While genodermatoses are rare with the prevalence rate of less than 1 in 50,000 – 200,000, they
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98031967819f4cb1bd6e9b55b98dada
https://doi.org/10.1111/exd.14314
https://doi.org/10.1111/exd.14314
Autor:
Vera Regitz-Zagrosek, Vignesh Jayarajan, Yury Ladilov, Avinash Appukuttan, Muhammad Aslam, Peter H Reusch
Publikováno v:
Cellular and Molecular Life Sciences. 76:4945-4959
The downregulation of AMP-activated protein kinase (AMPK) activity contributes to numerous pathologies. Recent reports suggest that the elevation of cellular cAMP promotes AMPK activity. However, the source of the cAMP pool that controls AMPK activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31d00c010e13ff0f7c9a44ba4a0c447
https://doi.org/10.1007/s00018-019-03152-y
https://doi.org/10.1007/s00018-019-03152-y
Autor:
Vignesh Jayarajan, Laura Rinaldi, Yury Ladilov, Sofya Pozdniakova, Yaser Abdallah, Muhammad Aslam, Christian Troidl
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:252-260
Aims Disturbance of mitochondrial function significantly contributes to the myocardial injury that occurs during reperfusion. Increasing evidence suggests a role of intra-mitochondrial cyclic AMP (cAMP) signaling in promoting respiration and ATP synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3e56baac425696175d93a126d08f61
https://doi.org/10.1016/j.bbadis.2018.07.021
https://doi.org/10.1016/j.bbadis.2018.07.021
Autor:
Aristides D, Tagalakis, Vignesh, Jayarajan, Ruhina, Maeshima, Kin H, Ho, Farhatullah, Syed, Lin-Ping, Wu, Ahmad M, Aldossary, Mustafa M, Munye, Talisa, Mistry, Olumide Kayode, Ogunbiyi, Arturo, Sala, Joseph F, Standing, Seyed M, Moghimi, Andrew W, Stoker, Stephen L, Hart
Publikováno v:
Advanced functional materials. 31(37)
The authors aim to develop siRNA therapeutics for cancer that can be administered systemically to target tumors and retard their growth. The efficacy of systemic delivery of siRNA to tumors with nanoparticles based on lipids or polymers is often comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc27ac1195fc4326e0883ead95c8ca8d
https://pubmed.ncbi.nlm.nih.gov/35712226
https://pubmed.ncbi.nlm.nih.gov/35712226