Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Viggo Linde"'
2
Two mutants of human heparin binding protein (CAP37): Toward the understanding of the nature of lipid A/LPS and BPTI binding
Autor: Jette S. Kastrup, Bjarne Stoffer, Poul Baad Rasmussen, Anja K. Pedersen, Hans Flodgaard, Lars Fogh Iversen, Søren E. Bjørn, Viggo Linde, Ingrid Kjøller Larsen
Publikováno v: Proteins: Structure, Function, and Bioinformatics. 42:442-451
Heparin binding protein (HBP) is an inactive serine protease homologue with important implications in host defense during infections and inflammations. Two mutants of human HBP, [R23S,F25E]HBP and [G175Q]HBP, have been produced to investigate structu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e8b7108432adc2ecfdf0c4a37776f34
https://doi.org/10.1002/1097-0134(20010301)42:4<442::aid-prot30>3.0.co
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4
High content translocation assays for pathway profiling
Autor: Frosty, Loechel, Sara, Bjørn, Viggo, Linde, Morten, Praestegaard, Len, Pagliaro
Publikováno v: Methods in molecular biology (Clifton, N.J.). 356
This chapter describes the design and development of cell-based assays, in which quantitation of the intracellular translocation of a target protein--rather than binding or catalytic activity--provides the primary assay readout. These are inherently
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::16c83ad33de9c1b9fee9721a4b5cd073
https://pubmed.ncbi.nlm.nih.gov/16988419
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5
High Content Translocation Assays for Pathway Profiling
Autor: Len Pagliaro, Viggo Linde, Morten Praestegaard, Frosty Loechel, Sara Petersen Bjørn
This chapter describes the design and development of cell-based assays, in which quantitation of the intracellular translocation of a target protein--rather than binding or catalytic activity--provides the primary assay readout. These are inherently
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f87e54ad19efe338dce871cda5f3c11
https://doi.org/10.1385/1-59745-217-3:401
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6
Identification of RAS-mitogen-activated protein kinase signaling pathway modulators in an ERF1 redistribution screen
Autor: Charlotta Grånäs, Morten Praestegaard, Viggo Linde, Søren Jensby Nielsen, Frosty Loechel, Betina Kerstin Lundholt, Sara Petersen Bjørn, Eva-Maria Damsgaard Nielsen, Hans-Christian Pedersen, Christian Krogh-Jensen
Publikováno v: Journal of biomolecular screening. 11(4)
The RAS-mitogen-activated protein kinase (MAPK) signaling pathway has a central role in regulating the proliferation and survival of both normal and tumor cells. This pathway has been 1 focus area for the development of anticancer drugs, resulting in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47fa1121ccaa13e89e2dc6708eaad465
https://pubmed.ncbi.nlm.nih.gov/16751337
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8
Identification of Akt pathway inhibitors using redistribution screening on the FLIPR and the IN Cell 3000 analyzer
Autor: Kurt Scudder, Per Arkhammar, Morten Praestegaard, Morten Heide, Viggo Linde, Ivan Mikkelsen, Søren Møller, Frosty Loechel, Robert Terry, Betina Kerstin Lundholt, Søren Jensby Nielsen, Hans-Christian Pedersen, Sara Petersen Bjørn
Publikováno v: Journal of biomolecular screening. 10(1)
The PI3-kinase/Akt pathway is an important cell survival pathway that is deregulated in the majority of human cancers. Despite the apparent druggability of several kinases in the pathway, no specific catalytic inhibitors have been reported in the lit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46b45c5db6197f59830e0119593d7ff
https://pubmed.ncbi.nlm.nih.gov/15695340
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9
Elimination of the Cys558-Cys566 bond in Lys78-plasminogen--effect on activation and fibrin interaction
Autor: Donald C. Foster, Lars Soegaard Nielsen, Viggo Linde, Lars Christian Petersen
Publikováno v: European journal of biochemistry. 251(1-2)
Plasminogen contains a unique disulphide bond, Cys558-Cys566, responsible for the cyclic nature of the peptide sequence surrounding the activation site at Arg561-Val562. A recombinant [Ser558, Ser566]-Lys78-plasminogen variant was produced in which t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39e6c3ac3ffc28963f1d5ea0c9a2878
https://pubmed.ncbi.nlm.nih.gov/9492320
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