The Development of LAT1 Efflux Agonists as Mechanistic Probes of Cellular Amino Acid Stress

Autor: Vandana Sekhar, Houssine Ikhlef, Alexandra Bunea, Viet S. Nguyen, Johan Joo, Mukund P. Tantak, Holly Moots, Otto Phanstiel

Publikováno v: Biomolecules, Vol 14, Iss 3, p 326 (2024)

Amino acid restriction induces cellular stress and cells often respond via the induction of autophagy. Autophagy or ‘self-eating’ enables the recycling of proteins and provides the essential amino acids needed for cell survival. Of the naturally

Externí odkaz: https://doaj.org/article/83076f736ef943178b3651a7c3bf56b4

The Development of LAT1 Efflux Agonists as Mechanistic Probes of Cellular Amino Acid Stress.

Autor: Sekhar, Vandana¹ (AUTHOR), Ikhlef, Houssine¹ (AUTHOR), Bunea, Alexandra¹ (AUTHOR), Nguyen, Viet S.¹ (AUTHOR), Joo, Johan¹ (AUTHOR), Tantak, Mukund P.¹ (AUTHOR), Moots, Holly¹ (AUTHOR), Phanstiel IV, Otto¹ (AUTHOR) otto.phanstiel@ucf.edu

Publikováno v: Biomolecules (2218-273X). Mar2024, Vol. 14 Issue 3, p326. 23p.

NIHSS cut point for predicting outcome in supra- vs infratentorial acute ischemic stroke.

Autor: Yoshimura S; From the Faculty of Medicine (S.Y., C.C., S.S., C.D., X.W., J.C., C.S.A.), The George Institute for Global Health, UNSW, Sydney, Australia; Department of Cerebrovascular Medicine (S.Y., S.S.), National Cerebral and Cardiovascular Center, Osaka, Japan; Sydney Medical School (R.I.L.), Westmead Hospital, University of Sydney; Neurology Department (C.C., C.D., C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Australia; and The George Institute China at Peking University Health Science Center (C.S.A.), Beijing, China., Lindley RI; From the Faculty of Medicine (S.Y., C.C., S.S., C.D., X.W., J.C., C.S.A.), The George Institute for Global Health, UNSW, Sydney, Australia; Department of Cerebrovascular Medicine (S.Y., S.S.), National Cerebral and Cardiovascular Center, Osaka, Japan; Sydney Medical School (R.I.L.), Westmead Hospital, University of Sydney; Neurology Department (C.C., C.D., C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Australia; and The George Institute China at Peking University Health Science Center (C.S.A.), Beijing, China., Carcel C; From the Faculty of Medicine (S.Y., C.C., S.S., C.D., X.W., J.C., C.S.A.), The George Institute for Global Health, UNSW, Sydney, Australia; Department of Cerebrovascular Medicine (S.Y., S.S.), National Cerebral and Cardiovascular Center, Osaka, Japan; Sydney Medical School (R.I.L.), Westmead Hospital, University of Sydney; Neurology Department (C.C., C.D., C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Australia; and The George Institute China at Peking University Health Science Center (C.S.A.), Beijing, China., Sato S; From the Faculty of Medicine (S.Y., C.C., S.S., C.D., X.W., J.C., C.S.A.), The George Institute for Global Health, UNSW, Sydney, Australia; Department of Cerebrovascular Medicine (S.Y., S.S.), National Cerebral and Cardiovascular Center, Osaka, Japan; Sydney Medical School (R.I.L.), Westmead Hospital, University of Sydney; Neurology Department (C.C., C.D., C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Australia; and The George Institute China at Peking University Health Science Center (C.S.A.), Beijing, China., Delcourt C; From the Faculty of Medicine (S.Y., C.C., S.S., C.D., X.W., J.C., C.S.A.), The George Institute for Global Health, UNSW, Sydney, Australia; Department of Cerebrovascular Medicine (S.Y., S.S.), National Cerebral and Cardiovascular Center, Osaka, Japan; Sydney Medical School (R.I.L.), Westmead Hospital, University of Sydney; Neurology Department (C.C., C.D., C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Australia; and The George Institute China at Peking University Health Science Center (C.S.A.), Beijing, China., Wang X; From the Faculty of Medicine (S.Y., C.C., S.S., C.D., X.W., J.C., C.S.A.), The George Institute for Global Health, UNSW, Sydney, Australia; Department of Cerebrovascular Medicine (S.Y., S.S.), National Cerebral and Cardiovascular Center, Osaka, Japan; Sydney Medical School (R.I.L.), Westmead Hospital, University of Sydney; Neurology Department (C.C., C.D., C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Australia; and The George Institute China at Peking University Health Science Center (C.S.A.), Beijing, China., Chalmers J; From the Faculty of Medicine (S.Y., C.C., S.S., C.D., X.W., J.C., C.S.A.), The George Institute for Global Health, UNSW, Sydney, Australia; Department of Cerebrovascular Medicine (S.Y., S.S.), National Cerebral and Cardiovascular Center, Osaka, Japan; Sydney Medical School (R.I.L.), Westmead Hospital, University of Sydney; Neurology Department (C.C., C.D., C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Australia; and The George Institute China at Peking University Health Science Center (C.S.A.), Beijing, China., Anderson CS; From the Faculty of Medicine (S.Y., C.C., S.S., C.D., X.W., J.C., C.S.A.), The George Institute for Global Health, UNSW, Sydney, Australia; Department of Cerebrovascular Medicine (S.Y., S.S.), National Cerebral and Cardiovascular Center, Osaka, Japan; Sydney Medical School (R.I.L.), Westmead Hospital, University of Sydney; Neurology Department (C.C., C.D., C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Australia; and The George Institute China at Peking University Health Science Center (C.S.A.), Beijing, China. canderson@georgeinstitute.org.cn.

Publikováno v: Neurology [Neurology] 2018 Oct 30; Vol. 91 (18), pp. e1695-e1701. Date of Electronic Publication: 2018 Sep 28.