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A Potent Kalihinol Analogue Disrupts Apicoplast Function and Vesicular Trafficking in P. falciparum Malaria.

Autor: Chahine Z; Department of Molecular, Cell and Systems Biology, University of California Riverside, CA, USA., Abel S; Department of Molecular, Cell and Systems Biology, University of California Riverside, CA, USA., Hollin T; Department of Molecular, Cell and Systems Biology, University of California Riverside, CA, USA., Chung JH; Department of Chemistry, University of California, Irvine, California, 92617, USA., Barnes GL; Department of Chemistry, University of California, Irvine, California, 92617, USA., Daub ME; Department of Chemistry, University of California, Irvine, California, 92617, USA., Renard I; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, Connecticut, USA., Choi JY; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, Connecticut, USA., Pratap V; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, Connecticut, USA., Pal A; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, Connecticut, USA., Alba-Argomaniz M; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, United States.; Center for Vaccines and Immunology, University of Georgia, Athens, GA, United States., Banks C; Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA., Kirkwood J; Metabolomics Core Facility, University of California, Riverside, CA 92521, USA., Saraf A; Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA., Camino I; GSK, C/ Severo Ochoa, 2 PTM, 28760 Tres Cantos (Madrid), Spain., Castaneda P; GSK, C/ Severo Ochoa, 2 PTM, 28760 Tres Cantos (Madrid), Spain., Cuevas MC; GSK, C/ Severo Ochoa, 2 PTM, 28760 Tres Cantos (Madrid), Spain., De Mercado-Arnanz J; GSK, C/ Severo Ochoa, 2 PTM, 28760 Tres Cantos (Madrid), Spain., Fernandez-Alvaro E; GSK, C/ Severo Ochoa, 2 PTM, 28760 Tres Cantos (Madrid), Spain., Garcia-Perez A; GSK, C/ Severo Ochoa, 2 PTM, 28760 Tres Cantos (Madrid), Spain., Ibarz N; GSK, C/ Severo Ochoa, 2 PTM, 28760 Tres Cantos (Madrid), Spain., Viera-Morilla S; GSK, C/ Severo Ochoa, 2 PTM, 28760 Tres Cantos (Madrid), Spain., Prudhomme J; Department of Molecular, Cell and Systems Biology, University of California Riverside, CA, USA., Joyner CJ; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, United States.; Center for Vaccines and Immunology, University of Georgia, Athens, GA, United States., Bei AK; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA., Florens L; Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA., Ben Mamoun C; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, Connecticut, USA., Vanderwal CD; Department of Chemistry, University of California, Irvine, California, 92617, USA., Le Roch KG; Department of Molecular, Cell and Systems Biology, University of California Riverside, CA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 22. Date of Electronic Publication: 2023 Nov 22.