Výsledky vyhledávání - "Vienna E Brunt"

Akademický článek

YI 1.4 Increases in Circulating Trimethylamine-N-Oxide Contribute to the Development of Age-Related Aortic Stiffness in Humans and Mice

Autor: Abigail G Casso, Rachel A Gioscia-Ryan, Zachary J Sapinsley, Nicholas S VanDongen, Amy E Bazzoni, Andrew P Neilson, Melanie C Zigler, Kevin P Davy, Douglas R Seals, Vienna E Brunt

Publikováno v: Artery Research, Vol 26, Iss Supplement 1 (2020)

Age-related increases in aortic stiffness, assessed by pulse wave velocity (PWV), predict cardiovascular (CV)-related mortality, but the upstream drivers are incompletely understood. Purpose: To determine if higher circulating levels of the gut micr

Externí odkaz: https://doaj.org/article/3a8b1dee1b01463e9bc2d518fbf70fdf

Zobrazit plný text záznamu

Akademický článek

Doxorubicin-Induced Oxidative Stress and Endothelial Dysfunction in Conduit Arteries Is Prevented by Mitochondrial-Specific Antioxidant Treatment

Autor: Zachary S. Clayton, PhD, Vienna E. Brunt, PhD, David A. Hutton, BA, Nicholas S. VanDongen, MS, Angelo D’Alessandro, PhD, Julie A. Reisz, PhD, Brian P. Ziemba, PhD, Douglas R. Seals, PhD

Publikováno v: JACC. CardioOncology, Vol 2, Iss 3, Pp 475-488 (2020)

Background: Doxorubicin (DOXO) chemotherapy increases risk for cardiovascular disease in part by inducing endothelial dysfunction in conduit arteries. However, the mechanisms mediating DOXO-associated endothelial dysfunction in (intact) arteries and

Externí odkaz: https://doaj.org/article/2689834d7b6241d3a9b0f5e5c561129a

Zobrazit plný text záznamu

Circulating interleukin-37 declines with aging in healthy humans: relations to healthspan indicators and IL37 gene SNPs

Autor: Vienna E. Brunt, Akpevweoghene P. Ikoba, Brian P. Ziemba, Dov B. Ballak, Alexander Hoischen, Charles A. Dinarello, Marissa A. Ehringer, Douglas R. Seals

Publikováno v: GeroScience, 45, 65-84
GeroScience, 45, 1, pp. 65-84

Item does not contain fulltext Aging is characterized by declines in physiological function that increase risk of age-associated diseases and limit healthspan, mediated in part by chronic low-grade inflammation. Interleukin (IL)-37 suppresses inflamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1960e332766f64900affb1af8bbfc21
https://hdl.handle.net/2066/291311

Zobrazit plný text záznamu

Initiation of 3,3‐dimethyl‐1‐butanol at midlife prevents endothelial dysfunction and attenuates in vivo aortic stiffening with ageing in mice

Autor: Abigail G. Casso, Nicholas S. VanDongen, Rachel A. Gioscia‐Ryan, Zachary S. Clayton, Nathan T. Greenberg, Brian P. Ziemba, David A. Hutton, Andrew P. Neilson, Kevin P. Davy, Douglas R. Seals, Vienna E. Brunt

Publikováno v: J Physiol

Vascular dysfunction: develops progressively with ageing; increases the risk of cardiovascular diseases (CVD); and is characterized by endothelial dysfunction and arterial stiffening, which are primarily mediated by superoxide-driven oxidative stress

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8c46c4008b75ad4322236fbccce4f1
https://doi.org/10.1113/jp283581

Zobrazit plný text záznamu

Suppression of trimethylamine N-oxide with DMB mitigates vascular dysfunction, exercise intolerance, and frailty associated with a Western-style diet in mice

Autor: Vienna E. Brunt, Nathan T. Greenberg, Zachary J. Sapinsley, Abigail G. Casso, James J. Richey, Nicholas S. VanDongen, Rachel A. Gioscia-Ryan, Brian P. Ziemba, Andrew P. Neilson, Kevin P. Davy, Douglas R. Seals

Publikováno v: Journal of Applied Physiology. 133:798-813

We provide novel evidence that increased circulating concentrations of the gut microbiome-derived metabolite trimethylamine N-oxide (TMAO) contribute to vascular dysfunction associated with consumption of a Western-style diet and that this dysfunctio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ba50b7ff3f131cfd29cc724131abcd
https://doi.org/10.1152/japplphysiol.00350.2022

Zobrazit plný text záznamu

Brachial and carotid hemodynamic response to hot water immersion in men and women

Autor: Sarianne M. Harris, Christopher T. Minson, John R. Halliwill, Vienna E. Brunt, Brett R. Ely, Emily A. Larson, Michael A. Francisco

Publikováno v: Am J Physiol Regul Integr Comp Physiol

This study sought to compare the brachial and carotid hemodynamic response to hot water immersion (HWI) between healthy young men and women. Ten women (W) and 11 men (M) (24 ± 4 yr) completed a 60-min HWI session immersed to the level of the sternum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bbb5dce4cc04d06f5cbc66e7295326e
https://doi.org/10.1152/ajpregu.00110.2021

Zobrazit plný text záznamu

Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans

Autor: Amy E Bazzoni, Andrew P. Neilson, Abigail G. Casso, Vienna E. Brunt, Melanie C. Zigler, Douglas R. Seals, David A. Hutton, James J Richey, Zachary J Sapinsley, Zachary S. Clayton, Kevin P. Davy, Brian P. Ziemba, Nicholas S. VanDongen, Rachel A. Gioscia-Ryan

Publikováno v: Hypertension. 78:499-511

Aging is associated with stiffening of the large elastic arteries and consequent increases in systolic blood pressure (SBP), which together increase cardiovascular disease risk; however, the upstream mechanisms are incompletely understood. Using comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9e8e35313458aae36f33b041f9179b0
https://doi.org/10.1161/hypertensionaha.120.16895

Zobrazit plný text záznamu

Heat therapy: mechanistic underpinnings and applications to cardiovascular health

Autor: Vienna E. Brunt, Christopher T. Minson

Publikováno v: J Appl Physiol (1985)

Cardiovascular diseases (CVD) are the leading cause of death worldwide, and novel therapies are drastically needed to prevent or delay the onset of CVD to reduce the societal and healthcare burdens associated with these chronic diseases. One such the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e299c375026f78bd1962615db5c071
https://doi.org/10.1152/japplphysiol.00141.2020

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání