Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Vien Chai"'
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Akademický článek
TTI-621 (SIRPαFc), a CD47-blocking cancer immunotherapeutic, triggers phagocytosis of lymphoma cells by multiple polarized macrophage subsets.
Autor: Gloria H Y Lin, Vien Chai, Vivian Lee, Karen Dodge, Tran Truong, Mark Wong, Lisa D Johnson, Emma Linderoth, Xinli Pang, Jeff Winston, Penka S Petrova, Robert A Uger, Natasja N Viller
Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0187262 (2017)
Tumor-associated macrophages (TAMs) are heterogeneous and can adopt a spectrum of activation states between pro-inflammatory and pro-tumorigenic in response to the microenvironment. We have previously shown that TTI-621, a soluble SIRPαFc fusion pro
Externí odkaz: https://doaj.org/article/aa6dada1a604425b82ab93e1b3dc47f2
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6
TTI-621 (SIRPαFc), a CD47-blocking cancer immunotherapeutic, triggers phagocytosis of lymphoma cells by multiple polarized macrophage subsets
Autor: Jeff Winston, Xinli Pang, Gloria H. Y. Lin, Mark Wong, Karen Dodge, Emma Linderoth, Penka S. Petrova, Vien Chai, Robert A. Uger, Tran Truong, Lisa Johnson, Natasja Nielsen Viller, Vivian Chi Yan Lee
Publikováno v: PLoS ONE
PLoS ONE, Vol 12, Iss 10, p e0187262 (2017)
Tumor-associated macrophages (TAMs) are heterogeneous and can adopt a spectrum of activation states between pro-inflammatory and pro-tumorigenic in response to the microenvironment. We have previously shown that TTI-621, a soluble SIRPαFc fusion pro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce5d2aa6ec0217c5e8479e30026ee293
https://pubmed.ncbi.nlm.nih.gov/29084248
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7
TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding
Autor: Mark Wong, Stephane Viau, Violetta House, Saman Maleki Vareki, Natasja Nielsen Viller, Rene Figueredo, Gloria H. Y. Lin, Tapfuma Mutukura, James Koropatnick, Karen Dodge, Penka S. Petrova, Vivian Chi Yan Lee, Vien Chai, Eric L. Sievers, Noel T. Vigo, Robert A. Uger, Debbie Jin, Suzanne Trudel, Lisa Johnson, Hui Chen, Tran Truong, Marilyse Charbonneau, Nathan Mbong, Emma Linderoth, Liqing Jin, Macarena Pampillo, Xinli Pang, Jean C.Y. Wang
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 23(4)
Purpose: The ubiquitously expressed transmembrane glycoprotein CD47 delivers an anti-phagocytic (do not eat) signal by binding signal-regulatory protein α (SIRPα) on macrophages. CD47 is overexpressed in cancer cells and its expression is associate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa655b9f2b33306985b7b4bdb9b7008b
https://pubmed.ncbi.nlm.nih.gov/27856600
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9
Abstract 2646: Intratumoral delivery of TTI-621 (SIRPαFc), a CD47-blocking immunotherapeutic, inhibits tumor growth and prolongs animal survival in a subcutaneous B cell lymphoma model
Autor: Jeffery Winston, Marilyse Charbonneau, Emma Linderoth, Lisa Johnson, Xinli Pang, Hui Chen, Robert A. Uger, Natasja Nielsen Viller, Gloria H. Y. Lin, Mark Wong, Penka S. Petrova, Vien Chai, Bolette Bossen, Alison M. O'Connor
Publikováno v: Cancer Research. 77:2646-2646
Tumor cells often evade macrophage-mediated destruction by increasing cell surface expression of CD47, which delivers an anti-phagocytic (“do-not-eat”) signal by binding the inhibitory signal-regulatory protein α (SIRPα) receptor on macrophages
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f350576a234171f71b7dbc7b18bf7e6
https://doi.org/10.1158/1538-7445.am2017-2646
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10
Abstract 2345: SIRPαFc, a CD47-blocking cancer immunotherapeutic, triggers phagocytosis of lymphoma cells by both classically (M1) and alternatively (M2) activated macrophages
Autor: Robert A. Uger, Vien Chai, Tran Truong, Gloria H. Y. Lin, Lisa Johnson, Mark Wong, Vivian S. Lee, Xinli Pang, Karen Dodge, Natasja Nielsen Viller, Penka S. Petrova
Publikováno v: Cancer Research. 76:2345-2345
Macrophages are characterized by their heterogeneity and plasticity in response to the microenvironment. Although macrophages have the capacity to phagocytose cancer cells that express pro-phagocytic signals, tumor cells often evade macrophage-mediat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0b2a11a05fb3529185bd09c4ef47f60
https://doi.org/10.1158/1538-7445.am2016-2345
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