Evaluation of adenoviral vector Ad19a encoding RSV-F as novel vaccine against respiratory syncytial virus

Autor: Jana Fuchs, Julian Hübner, Anna Schmidt, Pascal Irrgang, Clara Maier, Ana Vieira Antão, Friederike Oltmanns, Christian Thirion, Dennis Lapuente, Matthias Tenbusch

Publikováno v: npj Vaccines, Vol 9, Iss 1, Pp 1-15 (2024)

Abstract Respiratory syncytial virus (RSV) is the leading cause of severe lower respiratory tract infections in infants and toddlers. Since natural infections do not induce persistent immunity, there is the need of vaccines providing long-term protec

Externí odkaz: https://doaj.org/article/f6ca5b83ec59445c983e3d1cc0012d15

Mucosal tumor vaccination delivering endogenous tumor antigens protects against pulmonary breast cancer metastases

Autor: Claudia Gravekamp, Benjamin Frey, Carol Imanuel Geppert, Udo Gaipl, Michael Rückert, Anna Schmidt, Friederike Oltmanns, Ana Vieira Antão, Pascal Irrgang, Vera Viherlehto, Leticia Jörg, Jannik T Wagner, Ann-Sophie Flohr, Wibke Bayer, Matthias Tenbusch, Dennis Lapuente

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 3 (2024)

Background Generally, early-stage breast cancer has a good prognosis. However, if it spreads systemically, especially with pulmonary involvement, prospects worsen dramatically. Importantly, tumor-infiltrating T cells contribute to tumor control, part

Externí odkaz: https://doaj.org/article/2ff11b2291004e55aa0c500cd8410a20

Evaluation of adenoviral vector Ad19a encoding RSV-F as novel vaccine against respiratory syncytial virus.

Autor: Fuchs, Jana, Hübner, Julian, Schmidt, Anna, Irrgang, Pascal, Maier, Clara, Vieira Antão, Ana, Oltmanns, Friederike, Thirion, Christian, Lapuente, Dennis, Tenbusch, Matthias

Publikováno v: NPJ Vaccines; 10/29/2024, Vol. 9 Issue 1, p1-15, 15p

Protective mucosal immunity against SARS-CoV-2 after heterologous systemic RNA-mucosal adenoviral vector immunization

Autor: Markus Hoffmann, Leila Issmail, Jana Fuchs, Thomas Grunwald, Andrea Cara, Anna Schmidt, Stefan Poehlmann, Torsten Willert, Matthias Tenbusch, Christian Thirion, Pascal Irrgang, Klaus Ueberla, Ana Vieira Antão, Valentina Everlein, Nadja Uhlig, Dennis Lapuente, Jonas Willar, Antonia Sophia Peter, Sandra Mueller-Schmucker, Armin Ensser, Friederike Oltmanns, Kirsten Fraedrich, Cordula Pertl

Several effective SARS-CoV-2 vaccines are currently in use, but in the light of waning immunity and the emergence of novel variants, effective boost modalities are needed in order to maintain or even increase immunity. Here we report that intranasal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f02bd2865da324745bc4b02c72bc7fd
https://doi.org/10.1101/2021.08.03.454858

IL-7 as a mucosal adjuvant in pulmonary immunization protocols

Autor: Sandouk, A, Vieira Antão, A, Figueiredo, S., Charmeteau-De-Muylder, B, Alby-Laurent, F, Benard, M, Véron, E., Rancez, Magali, Cheynier, R, Couëdel-Courteille, A

Publikováno v: 52rd Annual Meeting of the French society for immunology (SFI 2019)
52rd Annual Meeting of the French society for immunology (SFI 2019), Nov 2019, Nantes, France

International audience; Objective: Mucosae are the gateway for many pathogens. However, few vaccines have been developed to specifically target mucosal immunity. Recent studies in the laboratory evidenced local expression of IL-7 in the acutely SIV-i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e5105bc473eeb3ca0bfd44ca2ce8643e
https://hal.archives-ouvertes.fr/hal-02998897