Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Vidyha Ravi"'
Autor:
Franz Ricklefs, Oliver Schnell, Vidyha Ravi, Dieter Henrik Heiland, Jürgen Beck, Kevin Joseph, Jan Kückelhaus, Jasim Kada Benotmane, Paulina Will
Publikováno v:
Neuro Oncol
High-dimensional technologies have provided insights into transcriptional heterogeneity and dynamic plasticity which are hallmarks of brain tumors. Although scRNA-seq recovers the diversity of transcriptional states, their spatial context within the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944f552c8554f40d35af2a2020dd5dce
https://europepmc.org/articles/PMC8598897/
https://europepmc.org/articles/PMC8598897/
Autor:
Kevin Joseph, Oliver Schnell, Dieter Henrik Heiland, Jürgen Beck, Ulrich G. Hofmann, Vidyha Ravi
Publikováno v:
Neuro-Oncology. 23:vi219-vi219
OBJECTIVE Glioblastoma (GBM) is among the most common of malignant brain tumours, with a median post-surgical survival of less than one year. Over the past several decades, therapies that appeared promising in mice models have failed during clinical
Autor:
Jürgen Beck, Kevin Joseph, Lea Vollmer, Dieter Henrik Heiland, Ulrich G. Hofmann, Oliver Schnell, Vidyha Ravi
Publikováno v:
Neuro Oncol
OBJECTIVE Owing to recent advances in understanding of the active functional states exhibited within glioblastoma (GBM), intra-tumoral cellular signaling has moved into focus of neuro-oncology. In this study, we aim to explore the diversity of transc
Autor:
Oliver Schnell, Jasim Kada Benotmane, Dieter Henrik Heiland, Jürgen Beck, Vidyha Ravi, Kevin Joseph, Jan Kückelhaus
Publikováno v:
Neuro Oncol
The diversity to T cell responses and clonality in spatially heterogeneous glioblastoma is of paramount importance to explore underlying mechanisms of anti-tumor immunity. Spatial transcriptomics, a novel technology to map the transcriptional archite
Autor:
Jasim Kada Benotmane, Kevin Joseph, Jan Kückelhaus, Oliver Schnell, Dieter Henrik Heiland, Jürgen Beck, Vidyha Ravi, Paulina Will
Publikováno v:
Neuro Oncol
Glioblastomas are embedded into an immunosuppressive microenvironment resulting in limited success of immunotherapies. Although, we and others observed defined myeloid-tumor crosslinks reducing T cell homing and activation, the spatial context of the
Autor:
Kevin Joseph, Oliver Schnell, Dieter Henrik Heiland, Ulrich G. Hofmann, Vidyha Ravi, Nicolas Neidert, Jürgen Beck, Paulina Will
Publikováno v:
Neuro-Oncology. 23:vi208-vi208
BACKGROUND Many central questions about the immunosuppressive microenvironment in glioblastoma (GBM) remain unanswered, particularly the interaction with lymphoid and myeloid populations. Here, we combined single-cell (scRNA) and spatial transcriptom
Publikováno v:
Neuro Oncol
BACKGROUND Owing to recent advances in understanding of the active functional states exhibited within glioblastoma (GBM), intra-tumoral cellular signaling has moved into focus of neuro-oncological research. In our study, we aim to explore the diversi