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pro vyhledávání: '"Vidyavathi Reddy"'
Autor:
Vidyavathi Reddy, Asm Iskander, Clara Hwang, George Divine, Mani Menon, Evelyn R Barrack, G Prem-Veer Reddy, Sahn-Ho Kim
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0211090 (2019)
Telomere stability is important for cell viability, as cells with telomere DNA damage that is not repaired do not survive. We reported previously that androgen receptor (AR) antagonist induces telomere DNA damage in androgen-sensitive LNCaP prostate
Externí odkaz:
https://doaj.org/article/607ad49b375c445eb2d9bad612ef676d
Autor:
Evelyn R. Barrack, Asm Iskander, Clara Hwang, Sahn-Ho Kim, Mani Menon, George Divine, Vidyavathi Reddy, G. Prem Veer Reddy
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0211090 (2019)
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PLoS ONE
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PLoS ONE
Telomere stability is important for cell viability, as cells with telomere DNA damage that is not repaired do not survive. We reported previously that androgen receptor (AR) antagonist induces telomere DNA damage in androgen-sensitive LNCaP prostate
Autor:
Vidyavathi Reddy, Nicholas Ciavattone, Nathan McKenty, Mani Menon, Sahn Ho Kim, G. Prem Veer Reddy, Evelyn R. Barrack, Min Wu
Publikováno v:
Journal of Biological Chemistry. 290:25522-25533
Androgen receptor (AR) plays a role in maintaining telomere stability in prostate cancer cells, as AR inactivation induces telomere dysfunction within 3 h. Since telomere dysfunction in other systems is known to activate ATM (ataxia telangiectasia mu
Autor:
Evelyn R. Barrack, M. Menon, Junying Zhou, Vidyavathi Reddy, G. Prem Veer Reddy, Sahn Ho Kim, Michelle Richardson
Publikováno v:
Aging (Albany NY)
Telomeres protect the ends of linear chromosomes from being recognized as damaged DNA, and telomere stability is required for genome stability. Here we demonstrate that telomere stability in androgen receptor (AR)-positive LNCaP human prostate cancer
Publikováno v:
Cancer Research. 76:1815-1815
Prostate cancer is the most commonly diagnosed non-skin cancer, and second leading cause of cancer deaths, in American men. The androgen receptor (AR) plays a critical role in the survival of prostate cancer (PCa) cells. Therefore, treatments that in