Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Vidyasiri Vemulapalli"'
Publikováno v:
Bio-Protocol, Vol 12, Iss 3 (2022)
Cells sense and respond to mitogens by activating a cascade of signaling events, primarily mediated by tyrosine phosphorylation (pY). Because of its key roles in cellular homeostasis, deregulation of this signaling is often linked to oncogenesis. To
Externí odkaz:
https://doaj.org/article/d5bbbef2e9b446dcba9c3bf6893a3086
Autor:
Vidyasiri Vemulapalli, Lily A Chylek, Alison Erickson, Anamarija Pfeiffer, Khal-Hentz Gabriel, Jonathan LaRochelle, Kartik Subramanian, Ruili Cao, Kimberley Stegmaier, Morvarid Mohseni, Matthew J LaMarche, Michael G Acker, Peter K Sorger, Steven P Gygi, Stephen C Blacklow
Publikováno v:
eLife, Vol 10 (2021)
SHP2 is a protein tyrosine phosphatase that normally potentiates intracellular signaling by growth factors, antigen receptors, and some cytokines, yet is frequently mutated in human cancer. Here, we examine the role of SHP2 in the responses of breast
Externí odkaz:
https://doaj.org/article/653eeb5ad6e5454e9488ec62514b8bc7
Autor:
Jonathan R. LaRochelle, Michelle Fodor, Vidyasiri Vemulapalli, Morvarid Mohseni, Ping Wang, Travis Stams, Matthew J. LaMarche, Rajiv Chopra, Michael G. Acker, Stephen C. Blacklow
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Activating mutations of the non-receptor protein tyrosine phosphatase SHP2 can cause cancer. Here the authors present the crystal structure of SHP2E76K, the most frequent cancer-associated SHP2 mutation, which adopts an open-state structure and show
Externí odkaz:
https://doaj.org/article/d0fced2ac7bd48d8ba126a11fc5bed5f
Autor:
Jesper V. Olsen, Lars J. Jensen, Kim Theilgaard-Mönch, Stephen C. Blacklow, Vidyasiri Vemulapalli, Kristian Reckzeh, Ilaria Piga, Marie Locard-Paulet, Giulia Franciosa, Anamarija Pfeiffer
Supplementary Data from Phosphorylation of SHP2 at Tyr62 Enables Acquired Resistance to SHP2 Allosteric Inhibitors in FLT3-ITD–Driven AML
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e44e4fc3515e4df0e347ed1a54c643c
https://doi.org/10.1158/0008-5472.22430284
https://doi.org/10.1158/0008-5472.22430284
Autor:
Jesper V. Olsen, Lars J. Jensen, Kim Theilgaard-Mönch, Stephen C. Blacklow, Vidyasiri Vemulapalli, Kristian Reckzeh, Ilaria Piga, Marie Locard-Paulet, Giulia Franciosa, Anamarija Pfeiffer
The protein tyrosine phosphatase SHP2 is crucial for oncogenic transformation of acute myeloid leukemia (AML) cells expressing mutated receptor tyrosine kinases. SHP2 is required for full RAS-ERK activation to promote cell proliferation and survival
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78e5a2bf99c8efb8cfecfca5df859849
https://doi.org/10.1158/0008-5472.c.6513577.v1
https://doi.org/10.1158/0008-5472.c.6513577.v1
Autor:
Jesper V. Olsen, Lars J. Jensen, Kim Theilgaard-Mönch, Stephen C. Blacklow, Vidyasiri Vemulapalli, Kristian Reckzeh, Ilaria Piga, Marie Locard-Paulet, Giulia Franciosa, Anamarija Pfeiffer
Supplementary Table from Phosphorylation of SHP2 at Tyr62 Enables Acquired Resistance to SHP2 Allosteric Inhibitors in FLT3-ITD–Driven AML
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3670270ef0f89fb2bad014be2a715886
https://doi.org/10.1158/0008-5472.22430254.v1
https://doi.org/10.1158/0008-5472.22430254.v1
Autor:
Jesper V. Olsen, Lars J. Jensen, Kim Theilgaard-Mönch, Stephen C. Blacklow, Vidyasiri Vemulapalli, Kristian Reckzeh, Ilaria Piga, Marie Locard-Paulet, Giulia Franciosa, Anamarija Pfeiffer
Supplementary Figure from Phosphorylation of SHP2 at Tyr62 Enables Acquired Resistance to SHP2 Allosteric Inhibitors in FLT3-ITD–Driven AML
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a286fc679490997ba56e2737835e74
https://doi.org/10.1158/0008-5472.22430278
https://doi.org/10.1158/0008-5472.22430278
Autor:
Ryan J. Lumpkin, Julia M. Rogers, Eric S. Fischer, Katherine A. Donovan, Ruili Cao, Vidyasiri Vemulapalli, Gregory D. Cuny, Soumya S. Ray, Stephen C. Blacklow, Matthew T. Henke, Munhyung Bae, Tom C. M. Seegar
Publikováno v:
Biochemistry
SHP2 is a protein tyrosine phosphatase that plays a critical role in the full activation of the Ras/MAPK pathway upon stimulation of receptor tyrosine kinases (RTKs), which are frequently amplified or mutationally activated in human cancer. In additi
Autor:
Anamarija Pfeiffer, Giulia Franciosa, Marie Locard-Paulet, Ilaria Piga, Kristian Reckzeh, Vidyasiri Vemulapalli, Stephen C. Blacklow, Kim Theilgaard-Mönch, Lars J. Jensen, Jesper V. Olsen
Publikováno v:
Cancer Res
Pfeiffer, A, Franciosa, G, Locard-Paulet, M, Piga, I, Reckzeh, K, Vemulapalli, V, Blacklow, S C, Theilgaard-Mönch, K, Jensen, L J & Olsen, J V 2022, ' Phosphorylation of SHP2 at Tyr62 enables acquired resistance to SHP2 allosteric inhibitors in FLT3-ITD-driven AML ', Cancer Research, vol. 82, no. 11, pp. 2141-2155 . https://doi.org/10.1158/0008-5472.CAN-21-0548
Pfeiffer, A, Franciosa, G, Locard-Paulet, M, Piga, I, Reckzeh, K, Vemulapalli, V, Blacklow, S C, Theilgaard-Mönch, K, Jensen, L J & Olsen, J V 2022, ' Phosphorylation of SHP2 at Tyr62 enables acquired resistance to SHP2 allosteric inhibitors in FLT3-ITD-driven AML ', Cancer Research, vol. 82, no. 11, pp. 2141-2155 . https://doi.org/10.1158/0008-5472.CAN-21-0548
The protein tyrosine phosphatase SHP2 is crucial for oncogenic transformation of acute myeloid leukemia (AML) cells expressing mutated receptor tyrosine kinases. SHP2 is required for full RAS-ERK activation to promote cell proliferation and survival
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a70518e71a8b0f7bfae33510da42823f
https://europepmc.org/articles/PMC9177641/
https://europepmc.org/articles/PMC9177641/
Autor:
Munhyung Bae, Tom C. M. Seegar, Ryan J. Lumpkin, Ruili Cao, Julia M. Rogers, Stephen C. Blacklow, Matthew T. Henke, Katherine A. Donovan, Vidyasiri Vemulapalli, Gregory D. Cuny, Eric S. Fischer
SHP2 is a protein tyrosine phosphatase that plays a critical role in the full activation of the Ras/MAPK pathway upon stimulation of receptor tyrosine kinases (RTKs), which are frequently amplified or mutationally activated in human cancer. In additi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98fe44701efe010ea5249a8d1bd44121
https://doi.org/10.1101/2021.06.02.446786
https://doi.org/10.1101/2021.06.02.446786