Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Vidyasagar Vuligonda"'
Autor:
Cheng-Hsin Wei, Lu Huang, Blair Kreh, Xiuxia Liu, Liliya Tyutyunyk-Massey, Masanori Kawakami, Zibo Chen, Mi Shi, Serguei Kozlov, King C. Chan, Thorkell Andresson, Mary Carrington, Vidyasagar Vuligonda, Martin E. Sanders, Amir Horowitz, Patrick Hwu, Weiyi Peng, Ethan Dmitrovsky, Xi Liu
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract All-trans-retinoic acid (ATRA), the retinoic acid receptors (RARs) agonist, regulates cell growth, differentiation, immunity, and survival. We report that ATRA-treatment repressed cancer growth in syngeneic immunocompetent, but not immunodef
Externí odkaz:
https://doaj.org/article/3a6d32daebaf4a6c91b60abe62aa93bd
Autor:
Robyn J. Novorolsky, Gracious D. S. Kasheke, Antoine Hakim, Marianna Foldvari, Gabriel G. Dorighello, Israel Sekler, Vidyasagar Vuligonda, Martin E. Sanders, Robert B. Renden, Justin J. Wilson, George S. Robertson
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
The neurovascular unit (NVU) is composed of vascular cells, glia, and neurons that form the basic component of the blood brain barrier. This intricate structure rapidly adjusts cerebral blood flow to match the metabolic needs of brain activity. Howev
Externí odkaz:
https://doaj.org/article/4979afa4fa504c8a99e9f3addcc3efee
Autor:
Cheng-Hsin Wei, Lu Huang, Blair Kreh, Xiuxia Liu, Liliya Tyutyunyk-Massey, Zibo Chen, Mi Shi, Vidyasagar Vuligonda, Martin Sanders, Serguei Kozlov, King Chan, Amir Horowitz, Mary Carrington, Patrick Hwu, Weiyi Peng, Ethan Dmitrovsky, Xi Liu
Publikováno v:
Cancer Research. 83:1836-1836
All-trans-retinoic acid (ATRA), a pan-agonist for retinoic acid receptors (RARs), regulates diverse cellular functions including growth, differentiation and immune function. We report here that ATRA-treatment represses tumor growth in syngeneic, immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a90ef888d5d82ccddae78966872228b
https://doi.org/10.1158/1538-7445.am2023-1836
https://doi.org/10.1158/1538-7445.am2023-1836
Autor:
Roshantha A.S. Chandraratna, Hieu T. Arpawong, Jia-Hao Xiao, Vidyasagar Vuligonda, Yi Zhao, Yumiko Okawa, Geoffrey Brown, Larissa I. Atangan, Suofu Qin, Yanira Molina, Corine Ghosn
Publikováno v:
Journal of Biological Chemistry. 279:30844-30849
Agonists of retinoid X receptors (RXRs), which include the natural 9-cis-retinoic acid and synthetic analogs, are potent inducers of growth arrest and apoptosis in some cancer cells. As such, they are being used in clinical trials for the treatment a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce9f5d5e4c1749097ec76df43b0364c
https://doi.org/10.1074/jbc.m404651200
https://doi.org/10.1074/jbc.m404651200
Autor:
Andrew M. Standeven, Maria Escobar, Roshantha A.S. Chandraratna, Yang-Dar Yuan, Vidyasagar Vuligonda, Richard L. Beard, Scott M. Thacher
Publikováno v:
Biochemical Pharmacology. 62:1501-1509
Hypertriglyceridemia is a major side-effect of retinoid therapy in humans. We previously reported that agonists for the retinoic acid receptors (RARs), but not the retinoid X receptors (RXRs), elevate serum triglycerides in male Fischer rats, and tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd33b9f7070667476ca351d3f016e38d
https://doi.org/10.1016/s0006-2952(01)00803-6
https://doi.org/10.1016/s0006-2952(01)00803-6
Publikováno v:
Journal of Medicinal Chemistry. 44:2298-2303
The synthesis and characterization of chiral RXR selective ligands are described. The enantiomeric acids 2 and 3 were synthesized employing an enantioselective cylopropanation procedure as the key step. Compound 2, with an S,S configuration at C-9 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe9eb6b93a5cccbc74d63a0a82132590
https://doi.org/10.1021/jm0100584
https://doi.org/10.1021/jm0100584
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:743-748
The synthesis and biological activity of a novel series of tricyclic retinoic acid receptor antagonists are described. These compounds bind with high affinity to the RARs and are potent antagonists of retinoid function in in vitro and in vivo systems
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927ee1b680e6440eb2fe4b4ce555b576
https://doi.org/10.1016/s0960-894x(99)00077-3
https://doi.org/10.1016/s0960-894x(99)00077-3
Publikováno v:
Tetrahedron Letters. 37:1941-1944
A simple procedure for selective conversion of α-tetralones to dihydronaphthalenes is described. A novel protic acid catalyzed hydride migration mechanism is proposed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14798eafe3cda30b8e96b62851b6f70b
https://doi.org/10.1016/0040-4039(96)00309-7
https://doi.org/10.1016/0040-4039(96)00309-7
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:213-218
Retinoids act through two distinct hormonal pathways activated by RAR and RXR ligands. We describe the synthesis of C9C10 locked retinoid analogs, including the most potent RXR - specific agonist known to date (Compound 5), and discuss the structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2af79ce0edf02fc75e775a71b8ab30d4
https://doi.org/10.1016/0960-894x(95)00588-k
https://doi.org/10.1016/0960-894x(95)00588-k
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41a3f5369d7a5905747b93e65d0e4758
https://doi.org/10.1002/chin.199621241
https://doi.org/10.1002/chin.199621241