Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Vidyasagar Reddy Gantla"'
Autor:
Ashley Dagley, Shibani Naik, Eric Brown, Brian B. Gowen, Alexandra Fetsko, Jonna B. Westover, Greg Henkel, Nicole Anderson, Dallan J. Blotter, Ken McCormack, Vidyasagar Reddy Gantla
Publikováno v:
Antiviral Res
Several arenaviruses, including Lassa and Lujo viruses in Africa and five New World arenavirus (NWA) species in the Americas, cause life-threatening viral hemorrhagic fevers. In the absence of licensed antiviral therapies, these viruses pose a signif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dec02e3a752f33cf6dc2c2874c7b9b8
https://europepmc.org/articles/PMC8378549/
https://europepmc.org/articles/PMC8378549/
Autor:
Eric Brown, E. Adam Kallel, Donald D. Lorimer, Arshil Master, Ken McCormack, Alexandra Fetsko, David M. Dranow, Nadezda V. Sokolova, Rana Sidhu, Alexander N. Freiberg, Vidyasagar Reddy Gantla, Plewe Michael Bruno, Jameson Bullen, Greg Henkel, Junru Wang, Shibani Naik, Birte Kalveram, Hayden Smutney, Lihong Zhang
Publikováno v:
ACS Med Chem Lett
[Image: see text] We identified and explored the structure–activity-relationship (SAR) of an adamantane carboxamide chemical series of Ebola virus (EBOV) inhibitors. Selected analogs exhibited half-maximal inhibitory concentrations (EC(50) values)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ff42b80f34362255a6026a7dd354b6
https://pubmed.ncbi.nlm.nih.gov/32550996
https://pubmed.ncbi.nlm.nih.gov/32550996
Autor:
Eric Brown, Vidyasagar Reddy Gantla, Landon R. Whitby, Ken McCormack, Joanne York, Dale L. Boger, Plewe Michael Bruno, Birte Kalveram, Jack H. Nunberg, Greg Henkel, Alexander N. Freiberg, Nadezda V. Sokolova, Shibani Naik, Lihong Zhang
Publikováno v:
Bioorg Med Chem Lett
Old World (Africa) and New World (South America) arenaviruses are associated with human hemorrhagic fevers. Efforts to develop small molecule therapeutics have yielded several chemical series including the 4-acyl-1,6-dialkylpiperazin-2-ones. Herein,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7c535f0257993692a376f476063d86
https://pubmed.ncbi.nlm.nih.gov/31537423
https://pubmed.ncbi.nlm.nih.gov/31537423
Autor:
Birte Kalveram, Alexander N. Freiberg, Eric Brown, Nadezda V. Sokolova, Greg Henkel, Shibani Naik, Ken McCormack, Alexandra Fetsko, Young-Jun Shin, Vidyasagar Reddy Gantla, Lihong Zhang, Plewe Michael Bruno
Publikováno v:
Bioorg Med Chem Lett
We identified and explored the structure–activity relationship (SAR) of a novel heterocyclic chemical series of arenavirus cell entry inhibitors. Optimized lead compounds, including diphenyl-substituted imidazo[1,2-a]pyridines, benzimidazoles, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3815392e3484cbe1e896b820a972ab00
https://doi.org/10.1016/j.bmcl.2021.127983
https://doi.org/10.1016/j.bmcl.2021.127983