Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Vidya Sarma"'
Autor:
Nikola Sladojevic, Svetlana M. Stamatovic, Richard F. Keep, Jamison J. Grailer, J. Vidya Sarma, Peter A. Ward, Anuska V. Andjelkovic
Publikováno v:
Neurobiology of Disease, Vol 67, Iss , Pp 57-70 (2014)
Proinflammatory mediators trigger intensive postischemic inflammatory remodeling of the blood–brain barrier (BBB) including extensive brain endothelial cell surface and junctional complex changes. Junctional adhesion molecule-A (JAM-A) is a compone
Externí odkaz:
https://doaj.org/article/be26f4c1339244e68041ab1d400ff618
Autor:
Daniel Rittirsch, Michael A Flierl, Danielle E Day, Brian A Nadeau, Firas S Zetoune, J Vidya Sarma, Clement M Werner, Guido A Wanner, Hans-Peter Simmen, Markus S Huber-Lang, Peter A Ward
Publikováno v:
PLoS Pathogens, Vol 5, Iss 6, p e1000464 (2009)
Pathogen-pattern-recognition by Toll-like receptors (TLRs) and pathogen clearance after immune complex formation via engagement with Fc receptors (FcRs) represent central mechanisms that trigger the immune and inflammatory responses. In the present s
Externí odkaz:
https://doaj.org/article/d667dbf35ae5439f9553526899f07d07
Autor:
Michael A Flierl, Daniel Rittirsch, Brian A Nadeau, J Vidya Sarma, Danielle E Day, Alex B Lentsch, Markus S Huber-Lang, Peter A Ward
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4414 (2009)
Following our recent report that phagocytic cells (neutrophils, PMNs, and macrophages) are newly discovered sources of catecholamines, we now show that both epinephrine and norepinephrine directly activate NFkappaB in macrophages, causing enhanced re
Externí odkaz:
https://doaj.org/article/53adeecc77f5476e864667a26cff11c3
Autor:
Michael A Flierl, Daniel Rittirsch, Anthony J Chen, Brian A Nadeau, Danielle E Day, J Vidya Sarma, Markus S Huber-Lang, Peter A Ward
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2560 (2008)
Sepsis remains a poorly understood, enigmatic disease. One of the cascades crucially involved in its pathogenesis is the complement system. Especially the anaphylatoxin C5a has been shown to have numerous harmful effects during sepsis. We have invest
Externí odkaz:
https://doaj.org/article/d4d89b11d81e42878bebbe5856046b62
Autor:
Jamison J. Grailer, José Jalife, Todd J. Herron, Firas S. Zetoune, Fatemeh Fattahi, Miriam Kalbitz, Sharlene M. Day, Mark W. Russell, Peter A. Ward, Hope Lu, J. Vidya Sarma, Markus Huber-Lang, Lawrence Jajou
Publikováno v:
The Journal of Immunology. 197:2353-2361
There is accumulating evidence during sepsis that cardiomyocyte (CM) homeostasis is compromised, resulting in cardiac dysfunction. An important role for complement in these outcomes is now demonstrated. Addition of C5a to electrically paced CMs cause
Publikováno v:
Journal of Innate Immunity. 6:607-618
The main drivers of acute inflammation are macrophages, which are known to have receptors for catecholamines. Based on their function, macrophages are broadly categorized as having either M1 (proinflammatory) or M2 phenotypes (anti-inflammatory). In
Autor:
Nico van Rooijen, Mathias Müller, Julian Roewe, Birgit Strobl, Markus P. Radsak, Markus Bosmann, Gabriel Núñez, Liza Balouzian, J. Vidya Sarma, Peter A. Ward, Firas S. Zetoune, Norman F. Russkamp, Peter J. Murray, Florence Pache
Publikováno v:
Bosmann, M, Russkamp, N F, Strobl, B, Roewe, J, Balouzian, L, Pache, F, Radsak, M P, van Rooijen, N, Zetoune, FS, Sarma, JV, Nunez, G, Muller, M, Murray, P J & Ward, PA 2014, ' Interruption of Macrophage-Derived IL-27(p28) Production by IL-10 during Sepsis Requires STAT3 but Not SOCS3 ', Journal of Immunology, vol. 193, no. 11, pp. 5668-5677 . https://doi.org/10.4049/jimmunol.1302280
Journal of Immunology, 193(11), 5668-5677. American Association of Immunologists
Journal of Immunology, 193(11), 5668-5677. American Association of Immunologists
Severe sepsis and septic shock are leading causes of morbidity and mortality worldwide. Infection-associated inflammation promotes the development and progression of adverse outcomes in sepsis. The effects of heterodimeric IL-27 (p28/EBI3) have been
Publikováno v:
European Journal of Immunology. 43:1907-1913
The complement activation product, C5a, is a key factor for regulation of inflammatory responses. C5a and C5adesArg bind to their receptors, C5aR and C5L2, but the functional roles of C5L2 remain controversial. We screened the patterns of 23 inflamma
Autor:
Norman F. Russkamp, J. Vidya Sarma, Peter A. Ward, Markus Bosmann, Jamison J. Grailer, Robert Ruemmler, Firas S. Zetoune
Publikováno v:
Shock. 39:447-452
Acute lung injury (ALI) is a severe pulmonary disease causing high numbers of fatalities worldwide. Innate immune responses are an integral part of the pathophysiologic events during ALI. Interleukin 23 (IL-23) is a proinflammatory mediator known to
Autor:
J. Vidya Sarma, Firas S. Zetoune, Peter A. Ward, Markus Bosmann, Mikel D. Haggadone, Fabien Meta, Robert Ruemmler
Publikováno v:
The American Journal of Pathology. 182:1124-1130
Severe sepsis is a life-threatening disease that causes major morbidity and mortality. Catecholamines and glucocorticoids often have been used for the treatment of sepsis. Several recent studies have suggested a potential role of IL-17 during the dev