Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Vidya P. Ramamurthy"'
Autor:
Retheesh S. Thankan, Elizabeth Thomas, Puranik Purushottamachar, David J. Weber, Vidya P. Ramamurthy, Weiliang Huang, Maureen A. Kane, Vincent C. O. Njar
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Triple-negative breast cancer (TNBC) and its recently identified subtype, quadruple negative breast cancer (QNBC), collectively account for approximately 13% of reported breast cancer cases in the United States. These aggressive forms of breast cance
Externí odkaz:
https://doaj.org/article/737183cf35254548863aff31a125b5a9
Publikováno v:
The FEBS Journal. 285:1051-1063
VNLG-152 is a novel retinamide (NR) shown to suppress growth and progression of genetically diverse prostate cancer cells via inhibition of androgen receptor signaling and eukaryotic initiation factor 4E (eIF4E) translational machinery. Herein, we re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ea6c1d9d7a847f9aedf9f5466653b36
https://doi.org/10.1111/febs.14383
https://doi.org/10.1111/febs.14383
Autor:
Senthilmurugan Ramalingam, Andrew K. Kwegyir-Afful, Arif Hussain, Vidya P. Ramamurthy, Vincent C. O. Njar
Publikováno v:
Current Opinion in Oncology. 29:210-220
The current overview will summarize some of the developments in the area of protein translation, including their relation to the therapeutic targeting of prostate cancer.Translational control, mediated by the rate-limiting eukaryotic translation init
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2b419ee4bf6e8c918e1b3c27a0b8c0
https://doi.org/10.1097/cco.0000000000000367
https://doi.org/10.1097/cco.0000000000000367
Autor:
Vidya P. Ramamurthy, Francis N. Murigi, Puranik Purushottamachar, Vincent C. O. Njar, Rena G. Lapidus, Yuji Zhang, Eun Yong Choi, Lalji K. Gediya, Maureen A. Kane, Tadas S. Vasaitis, Senthilmurugan Ramalingam, Weiliang Huang
Publikováno v:
Cancers, Vol 11, Iss 3, p 299 (2019)
Cancers
Volume 11
Issue 3
Cancers
Volume 11
Issue 3
Currently, there are no effective therapies for patients with triple-negative breast cancer (TNBC), an aggressive and highly metastatic disease. Activation of eukaryotic initiation factor 4E (eIF4E) by mitogen-activated protein kinase (MAPK)-interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321e328bf80b7a77dbd08328c4eba7e8
http://www.mdpi.com/2072-6694/11/3/299
http://www.mdpi.com/2072-6694/11/3/299
Autor:
Andrew K. Kwegyir-Afful, Marlena S. Martin, Puranik Purushottamachar, Vidya P. Ramamurthy, Senthilmurugan Ramalingam, Vincent C. O. Njar
Publikováno v:
ACS Medicinal Chemistry Letters. 7:708-713
Degradation of all forms of androgen receptors (ARs) is emerging as an advantageous therapeutic paradigm for the effective treatment of prostate cancer. In continuation of our program to identify and develop improved efficacious novel small-molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460f3d9be4459fe144dd5adbf90b1d70
https://doi.org/10.1021/acsmedchemlett.6b00137
https://doi.org/10.1021/acsmedchemlett.6b00137
Autor:
Njar Vco, Rena G. Lapidus, Vidya P. Ramamurthy, Lalji K. Gediya, Weiliang Huang, Senthilmurugan Ramalingam, Eun Yong Choi, Maureen A. Kane, Puranik Purushottamachar, Tadas S. Vasaitis, Yuji Zhang, Francis N. Murigi
Currently, there are no effective therapies for patients with triple-negative breast cancer (TNBC), an aggressive and highly metastatic disease. Activation of eukaryotic initiation factor 4E (eIF4E) by mitogen-activated protein kinase (MAPK)-interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac00abf4a7c534f0fc0d9402290f9692
https://doi.org/10.1101/439208
https://doi.org/10.1101/439208
Autor:
Vincent C. O. Njar, Puranik Purushottamachar, Senthilmurugan Ramalingam, Andrew K. Kwegyir-Afful, Vidya P. Ramamurthy
Publikováno v:
Oncotarget
Galeterone (Gal) is a first-in-class multi-target oral small molecule that will soon enter pivotal phase III clinical trials in castration resistant prostate cancer (CRPC) patients. Gal disrupts androgen receptor (AR) signaling via inhibition of CYP1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a16b54c564fbbd04a052f3faff98d7
https://doi.org/10.18632/oncotarget.4578
https://doi.org/10.18632/oncotarget.4578
Autor:
Vincent C. O. Njar, Marlena S. Martin, Hannah W. Mbatia, Andrew K. Kwegyir-Afful, Vidya P. Ramamurthy, Senthilmurugan Ramalingam
Publikováno v:
J Med Chem
The synthesis and in vitro and in vivo antibreast and antiprostate cancers activities of novel C-4 heteroaryl 13-cis-retinamides that modulate Mnk-eIF4E and AR signaling are discussed. Modifications of the C-4 heteroaryl substituents reveal that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7294dea240291ab1945901c7cd65b539
https://doi.org/10.1021/jm501792c
https://doi.org/10.1021/jm501792c
Autor:
Lalji K. Gediya, Andrew K. Kwegyir-Afful, Vidya P. Ramamurthy, Senthilmurugan Ramalingam, Vincent C. O. Njar
Publikováno v:
Oncotarget
Androgen receptor (AR) and MNK activated eIF4E signaling promotes the development and progression of prostate cancer (PCa). In this study, we report that our Novel Retinamides (NRs) target both AR signaling and eIF4E translation in androgen sensitive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ac42498507379792d9f6a240034eed
https://doi.org/10.18632/oncotarget.3084
https://doi.org/10.18632/oncotarget.3084
Autor:
Vidya P. Ramamurthy, Abhijit M. Godbole, Vijay V. Upreti, Hannah W. Mbatia, Lalji K. Gediya, Nicholas P. Ambulos, Vincent C. O. Njar, Puranik Purushottamachar, Aakanksha Khandelwal, Robert D. Bruno, Senthilmurugan Ramalingam, Sankar Addya
Publikováno v:
European Journal of Pharmacology. 734:98-104
Resistance to aromatase inhibitors is a major concern in the treatment of breast cancer. Long-term letrozole cultured (LTLC) cells represent a model of resistance to aromatase inhibitors. The LTLC cells were earlier generated by culturing MCF-7Ca, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3f737d8426ffa6d08a66b6f87a7591
https://doi.org/10.1016/j.ejphar.2014.04.004
https://doi.org/10.1016/j.ejphar.2014.04.004