Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Vidya P. Kumar"'
Time- and sex-dependent delayed effects of acute radiation exposure manifest via miRNA dysregulation
Autor:
Gregory P. Holmes-Hampton, Dharmendra Kumar Soni, Vidya P. Kumar, Shukla Biswas, Kefale Wuddie, Roopa Biswas, Sanchita P. Ghosh
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108867- (2024)
Summary: The detrimental effects of high-dose ionizing radiation on human health are well-known, but the influence of sex differences on the delayed effects of acute radiation exposure (DEARE) remains unclear. Here, we conducted six-month animal expe
Externí odkaz:
https://doaj.org/article/98aa12822cf64f47b756f591c754047f
Autor:
Gregory P. Holmes-Hampton, Vidya P. Kumar, Shukla Biswas, Sasha Stone, Neel K. Sharma, Betre Legesse, Justin Vercellino, Chandan Guha, Gary Eichenbaum, Sanchita P. Ghosh
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Thrombopoietin (TPO) is the primary regulator of platelet generation and a stimulator of multilineage hematopoietic recovery following exposure to total body irradiation (TBI). JNJ‑26366821, a novel PEGylated TPO mimetic peptide, stimulate
Externí odkaz:
https://doaj.org/article/29ff676478dc4f61943029825ec72491
Autor:
Patricia F. Boothe, Vidya P. Kumar, Yali Kong, Kan Wang, Howard Levinson, David Mu, Milton L. Brown
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8261 (2024)
Medical procedures, such as radiation therapy, are a vital element in treating many cancers, significantly contributing to improved survival rates. However, a common long-term complication of such exposure is radiation-induced skin fibrosis (RISF), a
Externí odkaz:
https://doaj.org/article/655f8cdd015e4cdb99c6be5076ce5a2c
Autor:
Dharmendra Kumar Soni, Vidya P. Kumar, Shukla Biswas, Gregory P. Holmes-Hampton, Sharmistha Bhattacharyya, Lawrence J. Thomas, Roopa Biswas, Sanchita P. Ghosh
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 569-584 (2022)
Risks of radiation exposure necessitate the development of radioprophylactic drugs. We have reported the efficacy of CDX-301, a recombinantly developed human protein form of Fms-related tyrosine kinase 3 ligand (Flt3L), as a radioprophylactic and rad
Externí odkaz:
https://doaj.org/article/a9d69ae6fab54273a63cbf87c390239d
Publikováno v:
Toxics, Vol 12, Iss 1, p 5 (2023)
IL-18 has been shown to play important roles in response to total body irradiation. However, homogenous total body irradiation is not a realistic model to reflect the radiation exposure in a real nuclear event. To further study the roles of IL-18 in
Externí odkaz:
https://doaj.org/article/6f5c0c31749c44c1a581b98a874e1da0
Autor:
Vidya P. Kumar, Gregory P. Holmes-Hampton, Shukla Biswas, Sasha Stone, Neel Kamal Sharma, Bernadette Hritzo, Mary Guilfoyle, Gary Eichenbaum, Chandan Guha, Sanchita P. Ghosh
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract The threat of a nuclear attack has increased in recent years highlighting the benefit of developing additional therapies for the treatment of victims suffering from Acute Radiation Syndrome (ARS). In this work, we evaluated the impact of a P
Externí odkaz:
https://doaj.org/article/8db84f097dc24630a7483f88f2f010e1
Autor:
Vidya P. Kumar, Shukla Biswas, Gregory P. Holmes-Hampton, Torsten Goesch, William Fahl, Sanchita P. Ghosh
Publikováno v:
Antioxidants, Vol 12, Iss 7, p 1417 (2023)
The development of safe, orally available, and effective prophylactic countermeasures to protect our warfighters is an unmet need because there is no such FDA-approved countermeasure available for use. Th 1-Propanethiol, 3-(methylamino)-2-((methylami
Externí odkaz:
https://doaj.org/article/1359e62fa92c41e0922088d69eba3114
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/b5e5eb9cf902431ba4c2853962f1688b
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Radiation injury will result in multiorgan dysfuntion leading to multiorgan failure. In addition to many factors such as radiation dose, dose rate, the severity of the injury will also depend on organ systems which are exposed. Here, we report the pr
Externí odkaz:
https://doaj.org/article/dbfc01995d6a4714856cc667a1a96b88
Autor:
Neel K. Sharma, Sasha Stone, Vidya P. Kumar, Shukla Biswas, Saeed Y. Aghdam, Gregory P. Holmes-Hampton, Christine M. Fam, George N. Cox, Sanchita P. Ghosh
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
Mitochondria are linked with various radiation responses, including mitophagy, genomic instability, apoptosis, and the bystander effect. Mitochondria play an important role in preserving cellular homeostasis during stress responses, and dysfunction i
Externí odkaz:
https://doaj.org/article/b94de2df0d2f42f0964fb8a4b2e11ca1