A phase I, randomized, ascending‐dose study to assess safety, pharmacokinetics, and activity of GDC‐8264, a RIP1 inhibitor, in healthy volunteers

Autor: Nicholas S. Jones, Smita Kshirsagar, Vishnu Mohanan, Vidya Ramakrishnan, Flavia Di Nucci, Ling Ma, Jialin Mao, Hao Ding, Sha Klabunde, Domagoj Vucic, Lin Pan, Annemarie N. Lekkerkerker, Yuan Chen, Michael E. Rothenberg

Publikováno v: Clinical and Translational Science, Vol 16, Iss 10, Pp 1997-2009 (2023)

Abstract Receptor‐interacting protein 1 (RIP1) is a key regulator of multiple signaling pathways that mediate inflammatory responses and cell death. RIP1 kinase activity mediates apoptosis and necroptosis induced by tumor necrosis factor (TNF)‐α

Externí odkaz: https://doaj.org/article/d142bcfea4d8440d95ab3f753b2b144b

Quantitative systems pharmacology model of the amyloid pathway in Alzheimer's disease: Insights into the therapeutic mechanisms of clinical candidates

Autor: Vidya Ramakrishnan, Christina Friedrich, Colleen Witt, Robert Sheehan, Meghan Pryor, Jasvinder K. Atwal, Kristin Wildsmith, Katherine Kudrycki, Seung‐Hye Lee, Norman Mazer, Carsten Hofmann, Reina N. Fuji, Jin Y. Jin, Saroja Ramanujan, Michael Dolton, Angelica Quartino

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 1, Pp 62-73 (2023)

Abstract Despite considerable investment into potential therapeutic approaches for Alzheimer's disease (AD), currently approved treatment options are limited. Predictive modeling using quantitative systems pharmacology (QSP) can be used to guide the

Externí odkaz: https://doaj.org/article/6c9f800424f0462f8528114142c69f0a

gQSPSim: A SimBiology‐Based GUI for Standardized QSP Model Development and Application

Autor: Iraj Hosseini, Justin Feigelman, Anita Gajjala, Monica Susilo, Vidya Ramakrishnan, Saroja Ramanujan, Kapil Gadkar

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 3, Pp 165-176 (2020)

Quantitative systems pharmacology (QSP) models are often implemented using a wide variety of technical workflows and methodologies. To facilitate reproducibility, transparency, portability, and reuse for QSP models, we have developed gQSPSim, a graph

Externí odkaz: https://doaj.org/article/add1386aea8a43a7a880d7a7032a4a8d

Safety and Efficacy of Semorinemab in Individuals with Prodromal to Mild Alzheimer Disease

Autor: Edmond, Teng, Paul T, Manser, Karen, Pickthorn, Flavia, Brunstein, Mira, Blendstrup, Sandra, Sanabria Bohorquez, Kristin R, Wildsmith, Bali, Toth, Michael, Dolton, Vidya, Ramakrishnan, Ashwini, Bobbala, Sietske A M, Sikkes, Michael, Ward, Reina N, Fuji, Geoffrey A, Kerchner, David, Weisman

Publikováno v: JAMA Neurology, 79(8), 758-767. American Medical Association
Teng, E, Manser, P T, Pickthorn, K, Brunstein, F, Blendstrup, M, Sanabria Bohorquez, S, Wildsmith, K R, Toth, B, Dolton, M, Ramakrishnan, V, Bobbala, A, Sikkes, S A M, Ward, M, Fuji, R N & Kerchner, G A 2022, ' Safety and Efficacy of Semorinemab in Individuals With Prodromal to Mild Alzheimer Disease : A Randomized Clinical Trial ', JAMA Neurology, vol. 79, no. 8, pp. 758-767 . https://doi.org/10.1001/jamaneurol.2022.1375
Teng, E, Manser, P T, Pickthorn, K, Brunstein, F, Blendstrup, M, Sanabria Bohorquez, S, Wildsmith, K R, Toth, B, Dolton, M, Ramakrishnan, V, Bobbala, A, Sikkes, S A M, Ward, M, Fuji, R N & Kerchner, G A 2022, ' Safety and Efficacy of Semorinemab in Individuals with Prodromal to Mild Alzheimer Disease : A Randomized Clinical Trial ', JAMA Neurology, vol. 79, no. 8, pp. 758-767 . https://doi.org/10.1001/jamaneurol.2022.1375

Importance: Neurofibrillary tangles composed of aggregated tau protein are one of the neuropathological hallmarks of Alzheimer disease (AD) and correlate with clinical disease severity. Monoclonal antibodies targeting tau may have the potential to am

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5221ef4dd6e70490909446ed6b1ce80
http://www.scopus.com/inward/record.url?scp=85132835366&partnerID=8YFLogxK

A Review on Drug‐Induced Nephrotoxicity: Pathophysiological Mechanisms, Drug Classes, Clinical Management, and Recent Advances in Mathematical Modeling and Simulation Approaches

Autor: Maher Chaar, Vidya Ramakrishnan, Jovin Lezeau, Lawrence J. Lesko, Sihem Ait-Oudhia, Kareem Taha, Hardik Mody, Adrian Rump

Publikováno v: Clinical Pharmacology in Drug Development. 9:896-909

A variety of marketed drugs belonging to various therapeutic classes are known to cause nephrotoxicity. Nephrotoxicity can manifest itself in several forms depending on the specific site involved as well as the underlying pathophysiological mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c0fa6d606d7e8c2a4bda059cd5068b
https://doi.org/10.1002/cpdd.879