Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Vidusha Devasthali"'
Autor:
Mallika Singh, Klaus P. Hoeflich, Mark Merchant, Richard Carano, Dorothy French, Michelle A. Nannini, William Forrest, Tim Cao, Hani Bou-Reslan, Emily Chan, Douglas Den Otter, Anne C. Clermont, Ciara Metcalfe, Joseph Castillo, Jason H. Cheng, Vidusha Devasthali, Melissa R. Junttila
Supplemental Fig 1,2,3. Tumor growth rates, overall survival and single agent GDC-0973 in vitro response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71abcd86d84e987877a60f47e42d7d98
https://doi.org/10.1158/1535-7163.22501464
https://doi.org/10.1158/1535-7163.22501464
Autor:
Mallika Singh, Klaus P. Hoeflich, Mark Merchant, Richard Carano, Dorothy French, Michelle A. Nannini, William Forrest, Tim Cao, Hani Bou-Reslan, Emily Chan, Douglas Den Otter, Anne C. Clermont, Ciara Metcalfe, Joseph Castillo, Jason H. Cheng, Vidusha Devasthali, Melissa R. Junttila
Activating mutations in the KRAS oncogene occur in approximately 90% of pancreatic cancers, resulting in aberrant activation of the MAPK and the PI3K pathways, driving malignant progression. Significant efforts to develop targeted inhibitors of nodes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec601dfc57c36d50faff96ead5e30713
https://doi.org/10.1158/1535-7163.c.6536796.v1
https://doi.org/10.1158/1535-7163.c.6536796.v1
Autor:
Jason H. Cheng, Douglas Den Otter, Hani Bou-Reslan, Vidusha Devasthali, Richard A.D. Carano, Emily Chan, Klaus P. Hoeflich, Anne C Clermont, Michelle Nannini, Mallika Singh, Ciara Metcalfe, Mark Merchant, Dorothy French, Joseph Castillo, Melissa R. Junttila, Tim C. Cao, William F. Forrest
Publikováno v:
Molecular Cancer Therapeutics. 14:40-47
Activating mutations in the KRAS oncogene occur in approximately 90% of pancreatic cancers, resulting in aberrant activation of the MAPK and the PI3K pathways, driving malignant progression. Significant efforts to develop targeted inhibitors of nodes
Autor:
Leslie Gay, Michael R. Miller, P. Britten Ventura, Vidusha Devasthali, Zer Vue, Heather L. Thompson, Sally Temple, Hui Zong, Michael D. Cleary, Kryn Stankunas, Chris Q. Doe
Publikováno v:
Genes & Development. 27:98-115
Transcriptional profiling is a powerful approach for understanding development and disease. Current cell type-specific RNA purification methods have limitations, including cell dissociation trauma or inability to identify all RNA species. Here, we de
Publikováno v:
Development.
Heart valve development proceeds through coordinated steps by which endocardial cushions (ECs) form thin, elongated, and stratified valves. Wnt signaling and its canonical effector β-catenin are proposed to contribute to endocardial-to-mesenchymal t
Autor:
William F. Forrest, Hani Bou Reslan, Ron Yu, Anne C Clermont, Jason H. Cheng, Richard A.D. Carano, Patricia Hamilton, Rafael Molina, Germaine Fuh, Anthony Lima, Calvin Ho, Vidusha Devasthali, Chingwei V. Lee, Hartmut Koeppen, Mallika Singh, Timothy C Cao, Gregory D. Plowman, Jennifer D. Thompson, Leisa Johnson, Michelle Nannini
Publikováno v:
Nature Biotechnology. 28:585-593
The low rate of approval of novel anti-cancer agents underscores the need for better preclinical models of therapeutic response as neither xenografts nor early-generation genetically engineered mouse models (GEMMs) reliably predict human clinical out
Publikováno v:
Organic letters. 6(20)
[reaction: see text] 1-deoxy-D-xylulose-5-phosphate (DXP) reductoisomerase is a NADPH-dependent enzyme catalyzing the conversion of DXP to methyl-D-erythritol 4-phosphate (MEP). In this study, each of the hydroxyl groups in DXP and one of its C-1 hyd