Výsledky vyhledávání - "Vido Ramassar"

Late Antibody-Mediated Rejection in a Large Prospective Cross-Sectional Study of Kidney Allograft Recipients--Preliminary Results of the Screening Phase of the BORTEJECT Trial

Autor: Farsad, Eskandary, Gregor, Bond, Heinz, Regele, Nicolas, Kozakowski, Zeljko, Kikić, Markus, Wahrmann, Helmuth, Haslacher, Rainer, Oberbauer, Vido, Ramassar, Philip, Halloran, Georg A, Böhmig

Publikováno v: Clinical transplants.

There is limited data on the rate of late antibody-mediated rejection (ABMR) in unselected transplant cohorts. Here, we investigated the prevalence and characteristics of ABMR in a large cohort of long-term kidney allograft recipients. Patients were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0e7a4d958ec618f0f683cf6063785642
https://pubmed.ncbi.nlm.nih.gov/26281144

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Changes in the Transcriptome in Allograft Rejection:IFN-γ-Induced Transcripts in Mouse Kidney Allografts

Autor: Gunilla Einecke, Konrad S. Famulski, P. F. Halloran, K. Allanach, Lin-Fu Zhu, Thomas F. Mueller, Vido Ramassar, Jeff Reeve, Luis G. Hidalgo

Publikováno v: American Journal of Transplantation. 6:1342-1354

We used Affymetrix Microarrays to define interferon-gamma (IFN-gamma)-dependent, rejection-induced transcripts (GRITs) in mouse kidney allografts. The algorithm included inducibility by recombinant IFN-gamma in kidneys of three normal mouse strains,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a816edf3a62c433cb71f3f76c8de5ce
https://doi.org/10.1111/j.1600-6143.2006.01337.x

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Heterogeneity in the Evolution and Mechanisms of the Lesions of Kidney Allograft Rejection in Mice

Autor: Lin Fu Zhu, Annette Sedlmeyer, Marjan Afrouzian, Joan Urmson, Philip F. Halloran, Luis G. Hidalgo, Wolfram J. Jabs, Vido Ramassar

Publikováno v: American Journal of Transplantation. 3:1501-1509

The natural history and pathogenesis of the pathologic lesions that define rejection of kidney transplants have not been well characterized. We studied the evolution of the pathology of rejection in mouse kidney allografts, using four strain combinat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c32413776d44f9dd7721c50d9a4e275
https://doi.org/10.1046/j.1600-6135.2003.00269.x

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Transcription Factor IRF-1 in Kidney Transplants Mediates Resistance to Graft Necrosis during Rejection

Autor: Vido Ramassar, Joan Urmson, Lin Fu Zhu, Philip F. Halloran, Marjan Afrouzian

Publikováno v: Journal of the American Society of Nephrology. 13:1199-1209

In many circumstances kidney transplants remain viable despite extensive inflammation, permitting rejection episodes to be reversed. The mechanisms by which the kidney resists host effector mechanisms are not known. In mouse kidney transplants, resis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2307ef7476a5ae063720d9b061dbf8
https://doi.org/10.1097/01.asn.0000013302.11876.a5

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Mycophenolate mofetil reduces production of interferon-dependent major histocompatibility complex induction during allograft rejection, probably by limiting clonal expansion

Autor: Sing Leung Lui, Vido Ramassar, Joan Urmson, Philip F. Halloran

Publikováno v: Transplant Immunology. 6:23-32

The immunosuppressive drug mycophenolate mofetil (MMF) acts by releasing mycophenolic acid (MPA), which inhibits the enzyme inosine monophosphate dehydrogenase (IMPDH) and thus inhibits de novo purine synthesis. Unlike cyclosporine (CsA), MMF has no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8940b6f35830eb040c80d6383bf13bd0
https://doi.org/10.1016/s0966-3274(98)80031-2

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IN VIVO CLASS II TRANSACTIVATOR EXPRESSION IN MICE IS INDUCED BY A NON-INTERFERON-?? MECHANISM IN RESPONSE TO LOCAL INJURY1,2

Autor: Nelson Goes, Vido Ramassar, Philip F. Halloran, Joan Urmson, Tasha N. Sims

Publikováno v: Transplantation. 64:1657-1664

Background Tissue injury induces MHC class II expression, which could be important in the recognition of that tissue as an allograft. The class II transcriptional activator (CIITA) is the major regulator of basal and induced MHC class II expression a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c3f429b0222f2f3b5798f34276522a3
https://doi.org/10.1097/00007890-199712270-00005

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EVIDENCE FOR THE IN VIVO ROLE OF CLASS II TRANSACTIVATOR IN BASAL AND IFN-?? INDUCED CLASS II EXPRESSION IN MOUSE TISSUE1,2

Autor: Michael G. Hobart, Vido Ramassar, Nelson Goes, Philip F. Halloran

Publikováno v: Transplantation. 62:1901-1907

The class II transactivator (CIITA) is a protein that induces the transcription of MHC class II genes. We studied the expression of CIITA in vivo, comparing steady state levels of CIITA and class II mRNA in various mouse tissues. Many tissues in norm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d06b58ec1d93f92a33babe482bbe55ab
https://doi.org/10.1097/00007890-199612270-00038

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ISCHEMIC ACUTE TUBULAR NECROSIS INDUCES AN EXTENSIVE LOCAL CYTOKINE RESPONSE

Autor: Joan Urmson, Philip F. Halloran, Nelson Goes, Vido Ramassar

Publikováno v: Transplantation. 59:565-572

We noted previously that ischemic acute tubular necrosis (ATN) induces local expression of MHC products in renal epithelium. The present investigations were conducted to establish the role of IFN-gamma in the regulation of MHC antigen expression in A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c97f0d6499026b46efcc48df5c70f1fb
https://doi.org/10.1097/00007890-199502270-00022

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Characterization of the transcriptome in isolated and transplanted mouse pancreatic islets: associations with engraftment and dysfunction

Autor: Shaheed Merani, Vido Ramassar, A. M. James Shapiro, Konrad S. Famulski, Philip F. Halloran

Publikováno v: Islets. 4(2)

The transplantation of pancreatic islets is an option for therapeutic management of hypoglycemia unawareness in select patients with type 1 diabetes mellitus. Characteristics of the transcriptome of freshly isolated islets, islet allografts, and isle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcbee8585b7a25eda1e6e46eda04eb45
https://pubmed.ncbi.nlm.nih.gov/22653155

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