Výsledky vyhledávání - "Vidia Roopchand"

Rational design of a highly immunogenic prefusion-stabilized F glycoprotein antigen for a respiratory syncytial virus vaccine

Publikováno v: Science Translational Medicine. 15

Respiratory syncytial virus (RSV) is the leading, global cause of serious respiratory disease in infants and is an important cause of respiratory illness in older adults. No RSV vaccine is currently available. The RSV fusion (F) glycoprotein is a key

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e71cd958b12d08fd24c41d4488d0fa2c
https://doi.org/10.1126/scitranslmed.ade6422

Zobrazit plný text záznamu

Nonreplicating Vaccines Can Protect African Green Monkeys From the Memphis 37 Strain of Respiratory Syncytial Virus

Publikováno v: Journal of Infectious Diseases. 208:319-329

Background. We evaluated the immunological responses of African green monkeys immunized with multiple F and G protein–based vaccines and assessed protection against the Memphis 37 strain of respiratory syncytial virus (RSV). Methods. Monkeys were i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d322dd2583760ad8a2e105c4aaeac2a
https://doi.org/10.1093/infdis/jit169

Zobrazit plný text záznamu

Coimmunization with an Optimized IL-15 Plasmid Results in Enhanced Function and Longevity of CD8 T Cells That Are Partially Independent of CD4 T Cell Help

Autor: Yutaka Tamura, Rose Parkinson, Sagar B. Kudchodkar, Maninder K. Sidhu, George N. Pavlakis, Daniel K. Choo, Michael A. Chattergoon, Vidia Roopchand, Michele A. Kutzler, Barbara K. Felber, J. Joseph Kim, Jean D. Boyer, Andrew Y. Choo, Tara M. Robinson, Thomas A. Waldmann, Mathura P. Ramanathan, David B. Weiner, Philip Y. Choe

Publikováno v: The Journal of Immunology. 175:112-123

DNA vaccines are a promising technology for the induction of Ag-specific immune responses, and much recent attention has gone into improving their immune potency. In this study we test the feasibility of delivering a plasmid encoding IL-15 as a DNA v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c1044195f0338ce4389792841e77b2
https://doi.org/10.4049/jimmunol.175.1.112

Zobrazit plný text záznamu

Non-propagating, recombinant vesicular stomatitis virus vectors encoding respiratory syncytial virus proteins generate potent humoral and cellular immunity against RSV and are protective in mice

Autor: Cheryl S. Kotash, Rebecca M. Nowak, Kathrin U. Jansen, Shakuntala Megati, Deanne M. Illenberger, Narender K. Kalyan, Emily Braunstein, Lisa K. McNeil, Maninder K. Sidhu, Irene Yurgelonis, J. Erik Johnson, Jennifer Obregon, Vidia Roopchand, Susan E. Witko

Publikováno v: Immunology letters. 150(1-2)

Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract illness in infants, the elderly, and other high-risk individuals. Despite years of research in this field, there is no effective licensed vaccine to prevent RSV infe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e77da8a58cd7f5e49c17d3c5a94f74b
https://pubmed.ncbi.nlm.nih.gov/23261719

Zobrazit plný text záznamu

Comparative ability of various plasmid-based cytokines and chemokines to adjuvant the activity of HIV plasmid DNA vaccines

Autor: Shakuntala Megati, John H. Eldridge, Maninder K. Sidhu, Rong Xu, Vidia Roopchand, David B. Weiner, Amara Luckay, Barbara K. Felber, Amjed Masood, Dorys Garcia-Hand, Margherita Rosati, Michael A. Egan, George N. Pavlakis

Publikováno v: Vaccine

The effectiveness of plasmid DNA (pDNA) vaccines can be improved by the co-delivery of plasmid-encoded molecular adjuvants. We evaluated pDNAs encoding GM-CSF, Flt-3L, IL-12 alone, or in combination, for their relative ability to serve as adjuvants t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4bc1100a124b63c59fdcb8419bd565
https://pubmed.ncbi.nlm.nih.gov/18657584

Zobrazit plný text záznamu

Modifying the HIV-1 env gp160 gene to improve pDNA vaccine-elicited cell-mediated immune responses

Autor: Dorys Garcia-Hand, David B. Weiner, Shakuntala Megati, Maninder K. Sidhu, Amjed Masood, Margherita Rosati, Larry R. Smith, Siew-Yen Chong, Rong Xu, Sarah Cappello, Amara Luckay, Zimra R. Israel, Michael A. Egan, Solomon Sackitey, George N. Pavlakis, Barbara K. Felber, John H. Eldridge, Vidia Roopchand

Publikováno v: Vaccine

Plasmid DNA (pDNA) vaccines are effective at eliciting immune responses in a wide variety of animal model systems, however, pDNA vaccines have generally been incapable of inducing robust immune responses in clinical trials. Therefore, to identify mea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703aaa15fe077667bce3fcb2ec1c6077
https://europepmc.org/articles/PMC7294827/

Zobrazit plný text záznamu

Effect of Plasmid DNA Vaccine Design and In Vivo Electroporation on the Resulting Vaccine-Specific Immune Responses in Rhesus Macaques▿

Autor: Rashed Abdullah, Ralph P. Braun, Siew-Yen Chong, Maninder K. Sidhu, George N. Pavlakis, Barbara K. Felber, David C. Montefiori, Margherita Rosati, Dorys Garcia-Hand, Iacob Mathiesen, Zimra R. Israel, Shakuntala Megati, John H. Eldridge, Vidia Roopchand, Michael A. Egan, Rune Kjeken, Amara Luckay

Since human immunodeficiency virus (HIV)-specific cell-mediated immune (CMI) responses are critical in the early control and resolution of HIV infection and correlate with postchallenge outcomes in rhesus macaque challenge experiments, we sought to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2069b8bc8f187c0cfbfa6c9c2569ef6b
https://europepmc.org/articles/PMC1900241/

Zobrazit plný text záznamu

A dose sparing effect by plasmid encoded IL-12 adjuvant on a SIVgag-plasmid DNA vaccine in rhesus macaques

Autor: John H. Eldridge, George N. Pavlakis, Shakuntala Megati, Vidia Roopchand, Priscilla Piacente, Barbara K. Felber, Jorge Quiroz, David B. Weiner, Zimra R. Israel, Sarah Cappello, Eva B. Schadeck, Dorys Garcia-Hand, Maninder K. Sidhu, Siew-Yen Chong, Jean D. Boyer, Michael A. Egan, Amjed Masood

Publikováno v: Vaccine. 24(21)

An experimental pDNA vaccine adjuvant expressing IL-12 was evaluated for its ability to augment the humoral and cellular immune responses elicited by a SIVmac239 gag p39 expressing pDNA vaccine. To determine the effect of vaccine dose on the immune r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3462249da61ee2d4585e9fd7fa2f544
https://pubmed.ncbi.nlm.nih.gov/16288822

Zobrazit plný text záznamu

Rational design of a plasmid DNA vaccine capable of eliciting cell-mediated immune responses to multiple HIV antigens in mice

Autor: Dorys Garcia-Hand, Maninder K. Sidhu, Siew-Yen Chong, Zimra R. Israel, John H. Eldridge, David B. Weiner, Vidia Roopchand, Margherita Rosati, Solomon Sackitey, Barbara K. Felber, Shakuntala Megati, George N. Pavlakis, Michael A. Egan, Amara Luckay

Publikováno v: Vaccine. 24(21)

Given the importance of the HIV-specific cell-mediated immune response in the early control and resolution of HIV infection and the observed correlation between pre-challenge vaccine elicited CTL responses and post challenge outcome in SHIV/rhesus ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81961ca87bbc1de39c98fc02461ad3c4
https://pubmed.ncbi.nlm.nih.gov/16140439

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání