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Akademický článek

Prospects and limitations of cumate-inducible lentivirus as a tool for investigating VEGF-A-mediated pathology in diabetic retinopathy

Autor: Inesa Lelyte, Vidhya R. Rao, Giedrius Kalesnykas, Symantas Ragauskas, Simon Kaja, Zubair Ahmed

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Abstract Diabetic retinopathy (DR) is a multifactorial disease displaying vascular-associated pathologies, including vascular leakage and neovascularization, ultimately leading to visual impairment. However, animal models accurately reflecting these

Externí odkaz: https://doaj.org/article/95bca3c8ce294d8c8cbb15c797015760

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Akademický článek

Screening Mycobacterium tuberculosis Secreted Proteins Identifies Mpt64 as a Eukaryotic Membrane-Binding Bacterial Effector

Autor: Chelsea E. Stamm, Breanna L. Pasko, Sujittra Chaisavaneeyakorn, Luis H. Franco, Vidhya R. Nair, Bethany A. Weigele, Neal M. Alto, Michael U. Shiloh

Publikováno v: mSphere, Vol 4, Iss 3 (2019)

ABSTRACT Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, is one of the most successful human pathogens. One reason for its success is that Mtb can reside within host macrophages, a cell type that normally functions to phagocyto

Externí odkaz: https://doaj.org/article/159f05ea47384c9c90842d3b47c3a1cf

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Akademický článek

Microfold Cells Actively Translocate Mycobacterium tuberculosis to Initiate Infection

Autor: Vidhya R. Nair, Luis H. Franco, Vineetha M. Zacharia, Haaris S. Khan, Chelsea E. Stamm, Wu You, Denise K. Marciano, Hideo Yagita, Beth Levine, Michael U. Shiloh

Publikováno v: Cell Reports, Vol 16, Iss 5, Pp 1253-1258 (2016)

The prevailing paradigm is that tuberculosis infection is initiated when patrolling alveolar macrophages and dendritic cells within the terminal alveolus ingest inhaled Mycobacterium tuberculosis (Mtb). However, definitive data for this model are lac

Externí odkaz: https://doaj.org/article/ad22e38945ad49b0a84e9a1b41892893

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Akademický článek

Differential Activation of Glioprotective Intracellular Signaling Pathways in Primary Optic Nerve Head Astrocytes after Treatment with Different Classes of Antioxidants

Autor: Anita K. Ghosh, Vidhya R. Rao, Victoria J. Wisniewski, Alexandra D. Zigrossi, Jamie Floss, Peter Koulen, Evan B Stubbs, Simon Kaja

Publikováno v: Antioxidants, Vol 9, Iss 4, p 324 (2020)

Optic nerve head astrocytes are the specialized glia cells that provide structural and trophic support to the optic nerve head. In response to cellular injury, optic nerve head astrocytes undergo reactive astrocytosis, the process of cellular activat

Externí odkaz: https://doaj.org/article/19004ed2bc894b5f8c967fe781385be0

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Akademický článek

cor, a Novel Carbon Monoxide Resistance Gene, Is Essential for Mycobacterium tuberculosis Pathogenesis

Autor: Vineetha M. Zacharia, Paolo S. Manzanillo, Vidhya R. Nair, Denise K. Marciano, Lisa N. Kinch, Nick V. Grishin, Jeffery S. Cox, Michael U. Shiloh

Publikováno v: mBio, Vol 4, Iss 6 (2013)

ABSTRACT Tuberculosis, caused by Mycobacterium tuberculosis, remains a devastating human infectious disease, causing two million deaths annually. We previously demonstrated that M. tuberculosis induces an enzyme, heme oxygenase (HO1), that produces c

Externí odkaz: https://doaj.org/article/1f534254f5d74508923b33aa7895a1f0

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