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Questioning rotary functionality in the bacterial flagellar system and proposing a murburn model for motility

Autor: Kelath Murali Manoj, Vivian David Jacob, Mahendra Kavdia, Hirohisa Tamagawa, Laurent Jaeken, Vidhu Soman

Bacterial flagellar system (BFS) was the primary example of a purported ‘rotary-motor’ functionality in a natural assembly. This mandates the translation of a circular motion of components inside into a linear displacement of the cell body outsid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9330f82891b9bf5bf0ab83829736aec1

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Questioning physiological rotary functionality in the bacterial flagellar system and proposing a murburn model for motility

Autor: Kelath Murali Manoj, Vivian David Jacob, Mahendra Kavdia, Hirohisa Tamagawa, Laurent Jaeken, Vidhu Soman

Bacterial flagellar system (BFS) was the first perceived example of a ‘natural rotary-motor” functionality, mandating the translation of a circular motion of components inside into a linear displacement of the cell body outside. This outcome is s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c74542430df46e12d0ee433a7c7a56b
https://doi.org/10.31219/osf.io/p9wua

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Acute toxicity of cyanide in aerobic respiration: Theoretical and experimental support for murburn explanation

Autor: Surjith Ramasamy, Daniel Andrew Gideon, Vidhu Soman, Kannan Pakshirajan, Kelath Murali Manoj, Vivian David Jacob, Abhinav Parashar

Publikováno v: Biomolecular Concepts, Vol 11, Iss 1, Pp 32-56 (2020)

The inefficiency of cyanide/HCN (CN) binding with heme proteins (under physiological regimes) is demonstrated with an assessment of thermodynamics, kinetics, and inhibition constants. The acute onset of toxicity and CN’s mg/Kg LD50(μM lethal conce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a060515302159de4ecae17220ff165c
https://doaj.org/article/228cc8af1f414fc2b2331de437f93dd3

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The Response of Bacterial Flagellar Motor to Stepwise Increase in NaCl Concentration

Autor: Vidhu Soman, Sunil Nath, S. Kumari, Ravikrishnan Elangovan

Many species of bacteria use flagella to navigate in its environment. The flagellum is a 7-10 μm long helical filament with a rotary motor at its base embedded in the cell membrane and almost a dozen stator complexes. Proton motive force across the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::462c64090d35be68e8d3d2b14efe6d21
https://doi.org/10.1101/2020.08.19.257477

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Effect of cell size and tethering geometry on rotation rate, torque, and rotational bias of E.coli cells

Autor: Kanishk Singh Malik, Vidhu Soman, Ravikrishnan Elangovan, Sunil Nath

The bacterial flagellum has a rotary motor embedded in its membrane surrounded by stator-units. Torque is generated by electro-steric interactions between rotor and stator-units. Chemotactic signals entail the motor to switch its direction of rotatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95c16c082deef847421be6f8a66847f4
https://doi.org/10.1101/2020.05.11.088310

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Chemiosmotic and murburn explanations for aerobic respiration: Predictive capabilities, structure-function correlations and chemico-physical logic

Autor: Afsal Manekkathodi, Kelath Murali Manoj, Manish Kumar, Surjith Ramasamy, Vivian David Jacob, Abhinav Parashar, Daniel Andrew Gideon, N. M. Bazhin, Kannan Pakshirajan, Vidhu Soman

Publikováno v: Archives of biochemistry and biophysics. 676

Since mid-1970s, the proton-centric proposal of ‘chemiosmosis’ became the acclaimed explanation for aerobic respiration. Recently, significant theoretical and experimental evidence were presented for an oxygen-centric ‘murburn’ mechanism of m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b70678b9e311ed10a3413c8605b2401d
https://pubmed.ncbi.nlm.nih.gov/31622585

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Chemiosmosis principle versus murburn concept: Why do cells need oxygen? Deducing the underpinnings of aerobic respiration by mechanistic predictability

Autor: Kelath Murali Manoj, Vidhu Soman, Vivian David Jacob, Abhinav Parashar, Daniel Andrew Gideon, Manish Kumar, Afsal Manekkathodi, Surjith Ramasamy, Kannan Pakshirajan

The long-standing explanation for cellular respiration (mitochondrial oxidative phosphorylation, mOxPhos) in textbooks is proton-centric and involves the elements of Rotary ATP synthesis, Chemiosmosis principle, Proton pumps and Electron transport ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c390274c1ddae47be31f7fe5d11292e7
https://doi.org/10.31219/osf.io/3jq8m

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Murburn concept explains the acutely lethal effect of cyanide

Autor: Kelath Murali Manoj, Surjith Ramasamy, Abhinav Parashar, Vidhu Soman, Kannan Pakshirajan

Cyanide (CN) toxicity is traditionally understood to result from its binding of hemeFe centers, thereby disrupting mitochondrial cytochrome oxidase function and oxygen utilization by other globin proteins. Recently, a diffusible reactive oxygen speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e802928178548ee339d2677afd92e5

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Role of Fumarate in the Operation of the Bacterial Flagellar Motor

Autor: Jyoti Sharma, Ravikrishnan Elangovan, Vidhu Soman, Sunil Nath

Publikováno v: Biophysical Journal. (2):600a

Fumarate has previously been identified as a ‘switch factor’ that can alter the switching frequency and bias of the sense of rotation of the bacterial flagellar motor; however, despite numerous studies during the past fifty years, the molecular m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f054f7768d38ea17e0d71f4bf01a74e

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