Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Vidhi, Pareek"'
Autor:
Qian Ma, Qiuhua Yang, Jiean Xu, Hunter G Sellers, Zach L Brown, Zhiping Liu, Zsuzsanna Bordan, Xiaofan Shi, Dingwei Zhao, Yongfeng Cai, Vidhi Pareek, Chunxiang Zhang, Guangyu Wu, Zheng Dong, Alexander D Verin, Lin Gan, Quansheng Du, Stephen J Benkovic, Suowen Xu, John M Asara, Issam Ben-Sahra, Scott Barman, Yunchao Su, David J R Fulton, Yuqing Huo
Publikováno v:
European Heart Journal. 44:1265-1279
Aims Proliferation of vascular smooth muscle cells (VSMCs) is a hallmark of pulmonary hypertension (PH). Proliferative cells utilize purine bases from the de novo purine synthesis (DNPS) pathways for nucleotide synthesis; however, it is unclear wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9329c8bdebe442e7d6f812bed7c84572
https://doi.org/10.1093/eurheartj/ehad044
https://doi.org/10.1093/eurheartj/ehad044
Autor:
Qian Ma, Qiuhua Yang, Jiean Xu, Xiaoyu Zhang, David Kim, Zhiping Liu, Qingen Da, Xiaoxiao Mao, Yaqi Zhou, Yongfeng Cai, Vidhi Pareek, Ha Won Kim, Guangyu Wu, Zheng Dong, Wen-Liang Song, Lin Gan, Chunxiang Zhang, Mei Hong, Stephen J. Benkovic, Neal L. Weintraub, David Fulton, John M. Asara, Issam Ben-Sahra, Yuqing Huo
Publikováno v:
Circulation. 146:1444-1460
Background: Proliferation of vascular smooth muscle cells (VSMCs) is a hallmark of arterial diseases, especially in arterial restenosis after angioplasty or stent placement. VSMCs reprogram their metabolism to meet the increased requirements of lipid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5565f06c97fa4a77b2181d860724fa0
https://doi.org/10.1161/circulationaha.121.058901
https://doi.org/10.1161/circulationaha.121.058901
Publikováno v:
Annu Rev Biochem
Over the past fifteen years, we have unveiled a new mechanism by which cells achieve greater efficiency in de novo purine biosynthesis. This mechanism relies on the compartmentalization of de novo purine biosynthetic enzymes into a dynamic complex ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333c844e34da5823e95012cd5f497755
https://doi.org/10.1146/annurev-biochem-032620-105728
https://doi.org/10.1146/annurev-biochem-032620-105728
Publikováno v:
Mol Cell
With the elucidation of a myriad anabolic and catabolic enzyme-catalyzed cellular pathways crisscrossing each other, an obvious question arose – how could these networks operate with maximal catalytic efficiency and minimal interference? A logical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b1b362cd92c0a452704a36bd994200
https://doi.org/10.1016/j.molcel.2021.08.030
https://doi.org/10.1016/j.molcel.2021.08.030
Autor:
Andrew J. Scott, Alexandra M. O'Brien, Weihua Zhou, Vidhi Pareek, Zhou Sha, Sravya Palavalasa, Ayesha U. Kothari, Kari Wilder-Romans, Li Zhang, Anthony C. Andren, Sriram Chandrasekaran, Jason Heth, Yoshie Umemura, Nathan Qi, John Woulfe, Sriram Venneti, Meredith A. Morgan, Theodore S. Lawrence, Wajd N. Al-Holou, Costas A. Lyssiotis, Daniel R. Wahl
Publikováno v:
Cancer Research. 83:3677-3677
Glioblastoma (GBM) is uniformly fatal due to inherent radiation (RT) and chemotherapy resistance. We have found this therapeutic resistance is mediated by alterations in tumor cellular metabolic activity. Our group and others have found that metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3812df9b68c6d94b4817140bedd15d15
https://doi.org/10.1158/1538-7445.am2023-3677
https://doi.org/10.1158/1538-7445.am2023-3677
Publikováno v:
The Journal of biological chemistry. 298(5)
There is growing evidence that mammalian cells deploy a mitochondria-associated metabolon called the purinosome to perform channeled de novo purine biosynthesis (DNPB). However, the molecular mechanisms of this substrate-channeling pathway are not we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea2a1c099dc8b0d0d365d16ab6f27c1
https://pubmed.ncbi.nlm.nih.gov/35331738
https://pubmed.ncbi.nlm.nih.gov/35331738
Autor:
Vaigundan Dhayabarn, Hemalatha Balaram, Padmanabhan Balaram, Patnam R. Krishnaswamy, Vidhi Pareek, Mathur R. N. Murthy
Leptospires are zoonotic pathogens that cause significant socio-economic burden in developing countries, world-wide. The pathogenic species Leptospira interrogans (Li) is an important and interesting target for investigating the enzymes essential to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6fbd2c253d675c41396660c537f9135
https://doi.org/10.1101/2020.12.04.412312
https://doi.org/10.1101/2020.12.04.412312
Publikováno v:
Crit Rev Biochem Mol Biol
The focus of this review is the human de novo purine biosynthetic pathway. The pathway enzymes are enumerated, as well as the reactions they catalyze and their physical properties. Early literature evidence suggested that they might assemble into a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57abdaa613842ec3207ba336b6065a7
https://pubmed.ncbi.nlm.nih.gov/33179964
https://pubmed.ncbi.nlm.nih.gov/33179964
Publikováno v:
Science (New York, N.Y.). 368(6488)
Signs of a metabolon in action Eukaryotic cells have a heterogeneous cytoplasm, with compartments large and small, membrane bound or not. Enzymes that catalyze the de novo synthesis of purine nucleotides, which are needed in rapidly dividing cells, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dbe44f72c37bac06d6b17f4c08aab7c
https://pubmed.ncbi.nlm.nih.gov/32299936
https://pubmed.ncbi.nlm.nih.gov/32299936
Publikováno v:
Behavioural Processes. 106:22-26
In many primitively eusocial wasp species new nests are founded either by a single female or by a small group of females. In the single foundress nests, the lone female develops her ovaries, lays eggs as well as tends her brood. In multiple foundress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47182a873753fbaf9c60cd8d80f02b8f
https://doi.org/10.1016/j.beproc.2014.04.003
https://doi.org/10.1016/j.beproc.2014.04.003