Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Vidar Sørum"'
Autor:
Vidar Sørum, Emma L. Øynes, Anna S. Møller, Klaus Harms, Ørjan Samuelsen, Nicole L. Podnecky, Pål J. Johnsen
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Collateral sensitivity and resistance occur when resistance development toward one antimicrobial either potentiates or deteriorates the effect of others. Previous reports on collateral effects on susceptibility focus on newly acquired resist
Externí odkaz:
https://doaj.org/article/1ee931cbd5cf489abdfb3468fc1c94ac
Autor:
Nicole L. Podnecky, Elizabeth G. A. Fredheim, Julia Kloos, Vidar Sørum, Raul Primicerio, Adam P. Roberts, Daniel E. Rozen, Ørjan Samuelsen, Pål J. Johnsen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Resistance to one antibiotic can in some cases increase susceptibility to other antibiotics. Here, Podnecky et al. study these collateral responses in E. coli clinical isolates and show that efflux-related resistance mechanisms and relative fitness o
Externí odkaz:
https://doaj.org/article/161a82352aa642d2845c098a4e132f54
Autor:
Christopher Fröhlich, Vidar Sørum, Ane Molden Thomassen, Pål Jarle Johnsen, Hanna-Kirsti S. Leiros, Ørjan Samuelsen
Publikováno v:
mSphere, Vol 4, Iss 2 (2019)
ABSTRACT Infections due to carbapenemase-producing Gram-negative pathogens are associated with limited treatment options and consequently lead to increased mortality and morbidity. In response, combinations of existing β-lactams and novel β-lactama
Externí odkaz:
https://doaj.org/article/17e5f96f1a714a89b3f195058f277abd
Publikováno v:
The Journal of antimicrobial chemotherapy. 77(9)
Background Cefiderocol is a novel siderophore β-lactam with improved hydrolytic stability toward β-lactamases, including carbapenemases, achieved by combining structural moieties of two clinically efficient cephalosporins, ceftazidime and cefepime.
Autor:
Vidar Sørum, Macarena Toll-Riera, Rafael Peña-Miller, Carmen de la Vega, Alvaro San Millan, Jerónimo Rodríguez-Beltrán
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 117 (27)
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 117 (27)
Proceedings of the National Academy of Sciences
Mobile genetic elements (MGEs), such as plasmids, promote bacterial evolution through horizontal gene transfer (HGT). However, the rules governing the repertoire of traits encoded on MGEs remain unclear. In this study, we uncovered the central role o
Autor:
Vidar Sørum, Emma L. Øynes, Anna S. Møller, Klaus Harms, Ørjan Samuelsen, Nicole L. Podnecky, Pål J. Johnsen
Collateral sensitivity and resistance occur when resistance development towards one antimicrobial either potentiates or deteriorates the effect of others, respectively. Previous reports on collateral effects on susceptibility focus on newly acquired
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2c1d86cb62983068ee17a890ffc3ae1
https://doi.org/10.1101/2021.10.26.465989
https://doi.org/10.1101/2021.10.26.465989
Autor:
Fanny Berglund, Nachiket P. Marathe, D. G. Joakim Larsson, Stathis D. Kotsakis, Christopher Fröhlich, Vidar Sørum, Hanna-Kirsti S. Leiros, Erik Kristiansson, Ørjan Samuelsen, Sandra Huber
Publikováno v:
Journal of Antimicrobial Chemotherapy
JAC-Antimicrobial Resistance (JAC-AMR)
'Journal of Antimicrobial Chemotherapy ', vol: 75, pages: 2554–2563 (2020)
JAC-Antimicrobial Resistance (JAC-AMR)
'Journal of Antimicrobial Chemotherapy ', vol: 75, pages: 2554–2563 (2020)
Background MBLs form a large and heterogeneous group of bacterial enzymes conferring resistance to β-lactam antibiotics, including carbapenems. A large environmental reservoir of MBLs has been identified, which can act as a source for transfer into
Autor:
Umaer Naseer, Irina Starikova, Pål Jarle Johnsen, Nils Hülter, Ørjan Samuelsen, Julia Maria Kloos, Vidar Sørum, Maria Chiara Di Luca
Publikováno v:
Journal of Antimicrobial Chemotherapy. 72:85-89
OBJECTIVES The objective of this study was to determine the biological cost, stability and sequence of two carbapenemase-encoding plasmids containing blaKPC-2 (pG12-KPC-2) and blaVIM-1 (pG06-VIM-1) isolated from Klebsiella pneumoniae when newly acqui
Autor:
Julia Maria Kloos, Elizabeth G. Aarag Fredheim, Raul Primicerio, Daniel E. Rozen, Adam P. Roberts, Nicole L Podnecky, Ørjan Samuelsen, Pål Jarle Johnsen, Vidar Sørum
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
There is urgent need to develop novel treatment strategies to reduce antimicrobial resistance. Collateral sensitivity (CS), where resistance to one antimicrobial increases susceptibility to other drugs, might enable selection against resistance durin
Autor:
Klaus Harms, Pål Jarle Johnsen, Mikkel Meyn Liljegren, Kristina Borch-Pedersen, Raul Primicerio, Nils Hülter, Vidar Sørum, Ane L G Utnes
Publikováno v:
Hülter, N, Sørum, V, Borch-Pedersen, K, Liljegren, M M, Utnes, A L G, Primicerio, R, Harms, K & Johnsen, P J 2017, ' Costs and benefits of natural transformation in Acinetobacter baylyi ', BMC Microbiology, vol. 17, 34 . https://doi.org/10.1186/s12866-017-0953-2
17:34
BMC Microbiology
17:34
BMC Microbiology
Background Natural transformation enables acquisition of adaptive traits and drives genome evolution in prokaryotes. Yet, the selective forces responsible for the evolution and maintenance of natural transformation remain elusive since taken-up DNA h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::229177f5b32cf93cddffa5dbf71ca294
http://hdl.handle.net/11250/2449496
http://hdl.handle.net/11250/2449496