Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Vida Ungerer"'
Autor:
Vida Ungerer, Abel J. Bronkhorst, Priscilla Van den Ackerveken, Marielle Herzog, Stefan Holdenrieder
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract Recent advances in basic research have unveiled several strategies for improving the sensitivity and specificity of cell-free DNA (cfDNA) based assays, which is a prerequisite for broadening its clinical use. Included among these strategies
Externí odkaz:
https://doaj.org/article/3d21f76d3af146979aaf89c988ffa78d
Autor:
Inga Medina Diaz, Annette Nocon, Stefanie A. E. Held, Makbule Kobilay, Dirk Skowasch, Abel J. Bronkhorst, Vida Ungerer, Johannes Fredebohm, Frank Diehl, Stefan Holdenrieder, Frank Holtrup
Publikováno v:
Diagnostics, Vol 13, Iss 7, p 1288 (2023)
Excellent pre-analytical stability is an essential precondition for reliable molecular profiling of circulating tumor DNA (ctDNA) in oncological diagnostics. Therefore, in vitro degradation of ctDNA and the additional release of contaminating genomic
Externí odkaz:
https://doaj.org/article/75a3dca641484427822aeb8e9a4e500f
Publikováno v:
Diagnostics, Vol 12, Iss 10, p 2550 (2022)
Plasma cell-free DNA (cfDNA) originates from various tissues and cell types and can enable minimally invasive diagnosis, treatment and monitoring of cancer and other diseases. Proper extraction of cfDNA is critical to obtain optimal yields and purity
Externí odkaz:
https://doaj.org/article/82bfbdc74c564faaa070e829dff2e33b
Autor:
Abel J. Bronkhorst, Vida Ungerer, Angela Oberhofer, Sophie Gabriel, Eleni Polatoglou, Hannah Randeu, Carsten Uhlig, Heiko Pfister, Zsuzsanna Mayer, Stefan Holdenrieder
Publikováno v:
Diagnostics, Vol 12, Iss 9, p 2147 (2022)
Body fluids are constantly replenished with a population of genetically diverse cell-free DNA (cfDNA) fragments, representing a vast reservoir of information reflecting real-time changes in the host and metagenome. As many body fluids can be collecte
Externí odkaz:
https://doaj.org/article/eaffee8f283e4ff48a1669cd90cdc907
Publikováno v:
Diagnostics, Vol 12, Iss 8, p 1896 (2022)
Unique bits of genetic, biological and pathological information occur in differently sized cell-free DNA (cfDNA) populations. This is a significant discovery, but much of the phenomenon remains to be explored. We investigated cfDNA fragmentation patt
Externí odkaz:
https://doaj.org/article/b5a463d52c2b4cc59f692efe889e330a
Publikováno v:
Diagnostics, Vol 12, Iss 8, p 1834 (2022)
All cell and tissue types constantly release DNA fragments into human body fluids by various mechanisms including programmed cell death, accidental cell degradation and active extrusion. Particularly, cell-free DNA (cfDNA) in plasma or serum has been
Externí odkaz:
https://doaj.org/article/e52b4919a9ff48b6bed4a7b1a3995508
Publikováno v:
Tumor Biology, Vol 42 (2020)
In vitro characterization of cell-free DNA using two-dimensional cell culture models is emerging as an important step toward an improved understanding of the physical and biological characteristics of cell-free DNA in human biology. However, precise
Externí odkaz:
https://doaj.org/article/47037875d3a9449d87c9abc652eae7d4
Comparison of methods for the quantification of cell-free DNA isolated from cell culture supernatant
Publikováno v:
Tumor Biology, Vol 41 (2019)
Gaining a better understanding of the biological properties of cell-free DNA constitutes an important step in the development of clinically meaningful cell-free DNA–based tests. Since the in vivo characterization of cell-free DNA is complicated by
Externí odkaz:
https://doaj.org/article/58467d036fcf40a3b0705a7992a1280b
Autor:
Abel Jacobus Bronkhorst, Johannes F Wentzel, Vida Ungerer, Dimetrie L Peters, Janine Aucamp, Etienne Pierre de Villiers, Stefan Holdenrieder, Piet J Pretorius
Publikováno v:
Tumor Biology, Vol 40 (2018)
The true importance of cell-free DNA in human biology, together with the potential scale of its clinical utility, is tarnished by a lack of understanding of its composition and origin. In investigating the cell-free DNA present in the growth medium o
Externí odkaz:
https://doaj.org/article/97cf857cfc46473ca7562642d2ea3b1a
Publikováno v:
Journal of Laboratory Medicine. 46:283-294
Programmed cell death, accidental cell degradation and active extrusion constantly lead to the release of DNA fragments into human body fluids from virtually all cell and tissue types. It is widely accepted that these cell-free DNA (cfDNA) molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bf2e7d6539ab895c32464d8e9d822c2
https://doi.org/10.1515/labmed-2022-0031
https://doi.org/10.1515/labmed-2022-0031