Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Victory Joseph"'
Autor:
Phyllis Chan, Han Ting Ding, Bianca M. Liederer, Jialin Mao, Paula Belloni, Liuxi Chen, Simon S. Gao, Victory Joseph, Xiaoying Yang, Joseph S. Lin, Mayur S. Mitra, Wendy S. Putnam, Angelica Quartino, Rebecca N. Bauer, Lin Pan
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 5, Pp 1945-1954 (2021)
Abstract GDC‐0334 is a novel small molecule inhibitor of transient receptor potential cation channel member A1 (TRPA1), a promising therapeutic target for many nervous system and respiratory diseases. The pharmacokinetic (PK) profile and pharmacody
Externí odkaz:
https://doaj.org/article/38338915571446a38eeb11b03b47d34b
Autor:
Han Ting Ding, Wendy S. Putnam, Simon S. Gao, Joseph Lin, Bianca M. Liederer, Jialin Mao, Angelica Quartino, Victory Joseph, Xiaoying Yang, Liuxi Chen, Paula Belloni, Phyllis Chan, Rebecca N. Bauer, Mayur S. Mitra, Lin Pan
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 5, Pp 1945-1954 (2021)
Clinical and Translational Science
Clinical and Translational Science
GDC‐0334 is a novel small molecule inhibitor of transient receptor potential cation channel member A1 (TRPA1), a promising therapeutic target for many nervous system and respiratory diseases. The pharmacokinetic (PK) profile and pharmacodynamic (PD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e14caea2d2691c3e776c7ba0522c5ea6
https://doaj.org/article/38338915571446a38eeb11b03b47d34b
https://doaj.org/article/38338915571446a38eeb11b03b47d34b
Autor:
Cory Thrasher, Simon S. Gao, Joseph Lin, Nand Singh, Robby M. Weimer, Rebecca N. Bauer, Wiebke Theess, Justin Elstrott, Victory Joseph, Xiaoying Yang
Publikováno v:
British Journal of Clinical Pharmacology. 87:129-139
Background and purpose Develop a translational assay of Transient Receptor Potential Ankyrin 1 (TRPA1) activity for use as a preclinical and clinical biomarker. Experimental approach Allyl isothiocyanate (AITC), capsaicin or citric acid were applied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ca22ecd980ad287b818464d41a2bbef
https://doi.org/10.1111/bcp.14370
https://doi.org/10.1111/bcp.14370
Autor:
Jun Chen, Justin Elstrott, Lan Wang, Simon S. Gao, Richard A.D. Carano, Jose E. Heredia, Elisia Villemure, Daniel G. Shore, Wyne P. Lee, Bobby Brillantes, Joseph H. Lin, Liling Liu, David H. Hackos, Jens Kortmann, Matthew Volgraf, Daniel D. Bravo, Christine Tam, Lorena Riol-Blanco, Steven Magnuson, Lionel Rouge, Chris Bjornson, Baihua Hu, Tania Chernov-Rogan, Rebecca M. Reese, Christopher P. Arthur, Min Jung, Michelle Dourado, Xiumin Wu, Victory Joseph, Alberto Estevez, John Liu, Alvin Gogineni, Juan Zhang, Laurie Leong, Jian Payandeh, Vishal Verma, Shannon D. Shields, Han Ting Ding, Brian Safina, Alessia Balestrini, Yong Chen, Vineela D. Gandham, Eric Suto, Jianyong Wang, Justin Ly, Rebecca N. Bauer, Jonas Doerr, Alexis Rohou, Cary D. Austin, Jason A. Vander Heiden, Xiaoying Yang, Ryan L. Wong, Lucinda Tam, Liuxi Chen, Kathy Hötzel, Kai H. Barck, Merone Roose-Girma, Claudio Ciferri, Huifen Chen, Bianca M. Liederer
Publikováno v:
Journal of Experimental Medicine. 218
Despite the development of effective therapies, a substantial proportion of asthmatics continue to have uncontrolled symptoms, airflow limitation, and exacerbations. Transient receptor potential cation channel member A1 (TRPA1) agonists are elevated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7586a7b163f0274f73ff2d6634f422f1
https://doi.org/10.1084/jem.20201637
https://doi.org/10.1084/jem.20201637
Autor:
Cindy Yun, Edwin R. Parra, John DeGroot, Victory Joseph, Ignacio I. Wistuba, Rebecca Harrison, Woodman Scott, Luisa M. Solis, Mark Knafl, Barbara O’Brien, Shiao-Pei Weathers, Carlos Kamiya-Matsuoka, Nazanin Majd, Andrew Futreal, Beatriz Sanchez Espiridion, Dipen M. Maru, Sharia Hernandez, Marta Penas-Prado, Monica Loghin, Walter Darbonne, W. K. Alfred Yung
Publikováno v:
Neuro-Oncology. 23:vi49-vi49
BACKGROUND Checkpoint inhibitor therapy has demonstrated overall limited efficacy in the treatment of GBM. Mechanisms of resistance to checkpoint blockade need to be better elucidated. Analysis of the tumor microenvironment is critical to identify co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3497abd30d751c565e8f0068875ef8a4
https://doi.org/10.1093/neuonc/noab196.196
https://doi.org/10.1093/neuonc/noab196.196
Autor:
Changlu Liu, Jiejun Wu, Neelakandha S. Mani, Xiaohu Deng, Victory Joseph, Chester Kuei, Siquan Sun
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:4888-4891
Synthesis of several 7-hydroxy oxysterols and their potential roles as signaling molecules in the innate and adaptive immune responses is discussed. Discovery of a new, fluorinated, synthetic analog of the 7α,25-dihydroxycholesterol-the endogenous l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919ce0db4c5423599e926365ef396ba3
https://doi.org/10.1016/j.bmcl.2016.09.029
https://doi.org/10.1016/j.bmcl.2016.09.029
Autor:
Nicholas J. Carruthers, Chester Kuei, Curt A. Dvorak, Jing Qian, Naiming Zhou, Changlu Liu, Jiejun Wu, Timothy W. Lovenberg, Victory Joseph, Grace Lee, He Xiaobai, Jingwen Yang
Publikováno v:
Immunology‚ Endocrine & Metabolic Agents in Medicinal Chemistry. 16:61-69
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e887f0044efcabff0ea1839b35b1e649
https://doi.org/10.2174/1871522215666150831203254
https://doi.org/10.2174/1871522215666150831203254
Publikováno v:
Behavioural Processes. 101:15-22
Previous research suggests animals may integrate temporal information into mental representations, or temporal maps. We examined the parameters under which animals integrate temporal information in three appetitive conditioning experiments. In Experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3225be788c71ecc607f00bb0e0a937
https://doi.org/10.1016/j.beproc.2013.08.015
https://doi.org/10.1016/j.beproc.2013.08.015
Autor:
Victory Joseph, Alfred S. Lewin, Michael T. Matthes, Marina S. Gorbatyuk, Matthew M. LaVail, Douglas Yasumura, Kelly Ahern, Wei-Chieh Chiang, Jonathan H. Lin
Publikováno v:
Retinal Degenerative Diseases ISBN: 9783319171203
RHO (Rod opsin) encodes a G-protein coupled receptor that is expressed exclusively by rod photoreceptors of the retina and forms the essential photopigment, rhodopsin, when coupled with 11-cis-retinal. Many rod opsin disease -mutations cause rod opsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fdc9b906d1593eecf8eaa93d41cd307
https://doi.org/10.1007/978-3-319-17121-0_25
https://doi.org/10.1007/978-3-319-17121-0_25
Autor:
Jiejun Wu, Nicholas I. Carruthers, Anthony Harrington, William A. Eckert, Grace Lee, Coate Heather R, Changlu Liu, Timothy W. Lovenberg, Steven W. Sutton, Victory Joseph, Chester Kuei, Sujin Yun, Diane Nepomuceno, Xiang Yao, Lynn Yieh, Qingqin Li, Christine Dugovic, Pascal Bonaventure, Curt A. Dvorak
Publikováno v:
Molecular pharmacology. 88(5)
GPR139 is an orphan G-protein-coupled receptor expressed in the central nervous system. To identify its physiologic ligand, we measured GPR139 receptor activity from recombinant cells after treatment with amino acids, orphan ligands, serum, and tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a403da982d84c8af8fa73e411bf06f
https://pubmed.ncbi.nlm.nih.gov/26349500
https://pubmed.ncbi.nlm.nih.gov/26349500