Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Victoria Vu"'
Autor:
Magdalena M. Szewczyk, Genna M. Luciani, Victoria Vu, Alex Murison, David Dilworth, Samir H. Barghout, Mathieu Lupien, Cheryl H. Arrowsmith, Mark D. Minden, Dalia Barsyte-Lovejoy
Publikováno v:
Redox Biology, Vol 51, Iss , Pp 102282- (2022)
Protein methyltransferase 5 (PRMT5) symmetrically dimethylates arginine residues leading to regulation of transcription and splicing programs. Although PRMT5 has emerged as an attractive oncology target, the molecular determinants of PRMT5 dependency
Externí odkaz:
https://doaj.org/article/8c9174ed85e342749dbc2bfff8c4fb40
Autor:
Patty Sachamitr, Jolene C. Ho, Felipe E. Ciamponi, Wail Ba-Alawi, Fiona J. Coutinho, Paul Guilhamon, Michelle M. Kushida, Florence M. G. Cavalli, Lilian Lee, Naghmeh Rastegar, Victoria Vu, María Sánchez-Osuna, Jasmin Coulombe-Huntington, Evgeny Kanshin, Heather Whetstone, Mathieu Durand, Philippe Thibault, Kirsten Hart, Maria Mangos, Joseph Veyhl, Wenjun Chen, Nhat Tran, Bang-Chi Duong, Ahmed M. Aman, Xinghui Che, Xiaoyang Lan, Owen Whitley, Olga Zaslaver, Dalia Barsyte-Lovejoy, Laura M. Richards, Ian Restall, Amy Caudy, Hannes L. Röst, Zahid Quyoom Bonday, Mark Bernstein, Sunit Das, Michael D. Cusimano, Julian Spears, Gary D. Bader, Trevor J. Pugh, Mike Tyers, Mathieu Lupien, Benjamin Haibe-Kains, H. Artee Luchman, Samuel Weiss, Katlin B. Massirer, Panagiotis Prinos, Cheryl H. Arrowsmith, Peter B. Dirks
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The arginine methyltransferase PRMT5 is over-expressed in cancer and has a role in the maintenance of stem cells. Here, the authors show that PRMT5 inhibitors can block the growth of patient derived glioblastoma stem cell cultures in vitro and in viv
Externí odkaz:
https://doaj.org/article/ce276d7ef43841fc91a953ffc3d02ecd
Autor:
Fabian Göricke, Victoria Vu, Leanna Smith, Ulrike Scheib, Raphael Böhm, Namik Akkilic, Gerd Wohlfahrt, Jörg Weiske, Ulf Bömer, Krzysztof Brzezinka, Niels Lindner, Philip Lienau, Stefan Gradl, Hartmut Beck, Peter J. Brown, Vijayaratnam Santhakumar, Masoud Vedadi, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, Norbert Schmees, Kirstin Petersen
Publikováno v:
Journal of Medicinal Chemistry. 66:3431-3447
Autor:
Victoria, Vu, Magdalena M, Szewczyk, David Y, Nie, Cheryl H, Arrowsmith, Dalia, Barsyte-Lovejoy
Publikováno v:
Annual Review of Biochemistry. 91:61-87
Small molecule chemical probes are valuable tools for interrogating protein biological functions and relevance as a therapeutic target. Rigorous validation of chemical probe parameters such as cellular potency and selectivity is critical to unequivoc
Autor:
Marcus A. Cheek, Aiping Dong, Renato Ferreira de Freitas, Dalia Barsyte-Lovejoy, Aliakbar Khalili Yazdi, Jinrong Min, Fengling Li, Victoria Vu, Albina Bolotokova, Lindsey I. James, Jack Greenblatt, Naimee Mehta, Irina K. Popova, David Dilworth, Ming Lei, Raquel Arminda Carvalho Machado, Ronan P Hanley, David Y Nie, Matthieu Schapira, Mengqi Zhou, Elisa Gibson, Cheryl H. Arrowsmith, Michael-Christopher Keogh, Suzanne Ackloo, Matthew R. Marunde, Mona Alqazzaz, Dmitri Kireev, Nathan W. Hall, Peter Brown, Abdellah Allali-Hassani, Sina Kazemzadeh, Edyta Marcon, Tigran M. Abramyan, Dominic D G Owens, Yanli Liu, Magdalena M. Szewczyk, Matthew J. Meiners, Irene Chau, Su Qin, Masoud Vedadi
Publikováno v:
Nat Chem Biol
Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with active gene transcription and intergenic DNA methylation. In addition to a methy
Autor:
Aiping Dong, Fengling Li, Alexandre Gagnon, Borhane Annabi, Shuay Abdullayev, Hong Zeng, Masoud Vedadi, Léa Mélin, Victoria Vu, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Levon Halabelian, Abdellah Allali-Hassani, Irene Chau, Ahmed Fnaiche, Magdalena M. Szewczyk, Simon Woo, Steven R. LaPlante, Guillermo Senisterra, Narjara Gonzalez Suarez
Publikováno v:
ChemMedChem. 16:2982-3002
The YAP-TEAD transcriptional complex is responsible for the expression of genes that regulate cancer cell growth and proliferation. Dysregulation of the Hippo pathway due to overexpression of TEAD has been reported in a wide range of cancers. Inhibit
Autor:
Nhat Tran, Heather Whetstone, Ian Restall, Patty Sachamitr, Julian Spears, Jasmin Coulombe-Huntington, Joseph Veyhl, Gary D. Bader, Mark Bernstein, Ahmed Aman, Mike Tyers, Hannes L. Röst, Sunit Das, Kirsten Hart, Bang-Chi Duong, Zahid Quyoom Bonday, Mathieu Lupien, Peter B. Dirks, Cheryl H. Arrowsmith, Maria M. Mangos, Laura M. Richards, Owen Whitley, Paul Guilhamon, María Sánchez-Osuna, H. Artee Luchman, Trevor J. Pugh, Jolene Caifeng Ho, Michael D. Cusimano, Samuel Weiss, Philippe Thibault, Amy Caudy, Olga Zaslaver, Panagiotis Prinos, Fiona J. Coutinho, Florence M.G. Cavalli, Wenjun Chen, Victoria Vu, Dalia Barsyte-Lovejoy, Xiaoyang Lan, Xinghui Che, Mathieu Durand, Michelle Kushida, Naghmeh Rastegar, Katlin B. Massirer, Benjamin Haibe-Kains, Lilian Lee, Evgeny Kanshin, Wail Ba-alawi, Felipe Ciamponi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Glioblastoma (GBM) is a deadly cancer in which cancer stem cells (CSCs) sustain tumor growth and contribute to therapeutic resistance. Protein arginine methyltransferase 5 (PRMT5) has recently emerged as a promising target in GBM. Using two orthogona
Publikováno v:
Journal of Visualized Experiments.
Protein methyltransferases (PRMTs) catalyze the transfer of a methyl group to arginine residues of substrate proteins. The PRMT family consists of nine members that can monomethylate or symmetrically/asymmetrically dimethylate arginine residues. Seve
Autor:
Tungalag Chuluunbaatar, Adrian J. Verster, Mark Spensley, Djina Pajkic, Michael R Schertzberg, G. Traver Hart, Victoria Vu, Andrew G. Fraser, Jason Moffat
Publikováno v:
Cell. (2):391-402
SummaryMany mutations cause genetic disorders. However, two people inheriting the same mutation often have different severity of symptoms, and this is partly genetic. The effects of genetic background on mutant phenotypes are poorly understood, but p
Publikováno v:
Orange County Business Journal. 2/12/2024, Vol. 47 Issue 7, p44-57. 10p.