Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Victoria Tobin"'
Autor:
Joseph Hiatt, Judd F. Hultquist, Michael J. McGregor, Mehdi Bouhaddou, Ryan T. Leenay, Lacy M. Simons, Janet M. Young, Paige Haas, Theodore L. Roth, Victoria Tobin, Jason A. Wojcechowskyj, Jonathan M. Woo, Ujjwal Rathore, Devin A. Cavero, Eric Shifrut, Thong T. Nguyen, Kelsey M. Haas, Harmit S. Malik, Jennifer A. Doudna, Andrew P. May, Alexander Marson, Nevan J. Krogan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here, Hiatt et al. report the knock-out of over 400 genes in primary CD4+ T cells to assess their functional role in HIV replication, finding 86 initial candidates of which 47 are validated as HIV host factors, including 23 with restrictive activity.
Externí odkaz:
https://doaj.org/article/4afe586db1e74b9e9e49556512d17fd5
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193452 (2018)
The laser Doppler imaging (LDI) FLARE and corneal confocal microscopy (CCM) are reliable markers of small fibre function (SFF) and structure (SFS), respectively, but the impact of potential confounding variables needs to be defined. The objective of
Externí odkaz:
https://doaj.org/article/6cfbaa45916242b6aa9137668fb9c173
Autor:
Linda T. Vo, P. Jonathan Li, Theodore L. Roth, Murad R. Mamedov, David N. Nguyen, Peixin Amy Chen, Eric Shifrut, Jeffrey A. Bluestone, Ryan Apathy, Alexander Marson, Francis C. Szoka, Jennifer M. Puck, Daniel B. Goodman, Victoria Tobin
Publikováno v:
Nature biotechnology
Nature biotechnology, vol 38, iss 1
Nature biotechnology, vol 38, iss 1
Versatile and precise genome modifications are needed to create a wider range of adoptive cellular therapies1-5. Here we report two improvements that increase the efficiency of CRISPR-Cas9-based genome editing in clinically relevant primary cell type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edaff5425b66396abfa68d401206e96a
https://doi.org/10.1038/s41587-019-0325-6
https://doi.org/10.1038/s41587-019-0325-6
Autor:
Julia Carnevale, P. Jonathan Li, Theodore L. Roth, Eric Shifrut, Jonathan M. Woo, Morgan E. Diolaiti, Alexander Marson, Alan Ashworth, Christina Bui, Victoria Tobin
Publikováno v:
Cell, vol 175, iss 7
SUMMARYHuman T cells are central effectors of immunity and cancer immunotherapy. CRISPR-based functional studies in T cells could prioritize novel targets for drug development and improve the design of genetically reprogrammed cell-based therapies. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66c0c69e2dfb2ae9a5f8bf6cc5e929f
Autor:
Gary M. Kupfer, Manuel D. Leonetti, Montse Morell, Michael Haugwitz, P. Jonathan Li, Kevan C. Herold, Justin Saco, Andrea L. Ferris, Ruby Yu, Daniela del Gaudio, Neil Romberg, Hiroyuki Matsumoto, Eric Shifrut, Victoria Tobin, Jonathan S. Weissman, Joseph Hiatt, Theodore L. Roth, Stephen H. Hughes, Min Cho, Jean Nicolas Schickel, Baz Smith, Amy L. Putnam, Michael R. Lee, Kathrin Schumann, Rosa Bacchetta, Ying Mao, Paige Krystofinski, David Carmody, Rolen M. Quadros, Gorka Alkorta-Aranburu, Julia Carnevale, Cristina Puig-Saus, Eric Meffre, Andrew P. May, Siri Atma W. Greeley, Laurence Pellerin, Han Li, David N. Nguyen, Maria Grazia Roncarolo, Alan Ashworth, Antoni Ribas, Channabasavaiah B. Gurumurthy, Alexander Marson, Jeff W. Chen, Jonathan H. Esensten
Publikováno v:
Nature, vol 559, iss 7714
Nature
Nature
Decades of work have aimed to genetically reprogram T cells for therapeutic purposes1,2 using recombinant viral vectors, which do not target transgenes to specific genomic sites3,4. The need for viral vectors has slowed down research and clinical use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c6039ce1b9fd8e46335281678832a5b
https://escholarship.org/uc/item/5rx2j6kz
https://escholarship.org/uc/item/5rx2j6kz
Autor:
Jonathan M. Woo, Alexander Marson, Eric Shifrut, Christina Bui, P. Jonathan Li, Julia Carnevale, Victoria Tobin, Morgan E. Diolaiti, Theodore L. Roth, Alan Ashworth
Publikováno v:
Cell. 175(7)
Human T cells are central effectors of immunity and cancer immunotherapy. CRISPR-based functional studies in T cells could prioritize novel targets for drug development and improve the design of genetically reprogrammed cell-based therapies. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::432d20b6769d0fbcbe5af1cc9f6d21fc
https://pubmed.ncbi.nlm.nih.gov/30449619
https://pubmed.ncbi.nlm.nih.gov/30449619
Autor:
Maxwell R. Mumbach, Nicki Naddaf, Theodore L. Roth, Nicolas Bray, Ruize Liu, Chun Jimmie Ye, K. Mark Ansel, Graham J. Ray, Mark S. Anderson, Dmytro Lituiev, Benjamin G. Gowen, Zhongmei Li, Therese Mitros, John D. Gagnon, Kyle Kai-How Farh, Hong Ma, Jacob E. Corn, Eric Boyer, Hailiang Huang, Youjin Lee, William J. Greenleaf, Rachel E. Gate, Victoria Tobin, Julia S. Chu, Meena Subramaniam, Ansuman T. Satpathy, Kathrin Schumann, Gemma L. Curie, Alexander Marson, Alice Y. Chan, Jonathan M. Woo, Mandy Boontanrart, Mark J. Daly, Michelle L.T. Nguyen, Frédéric Van Gool, Dimitre R. Simeonov, Howard Y. Chang, Jeffrey A. Bluestone
Publikováno v:
Nature. 559(7715)
The majority of genetic variants associated with common human diseases map to enhancers, non-coding elements that shape cell-type-specific transcriptional programs and responses to extracellular cues1–3. Systematic mapping of functional enhancers a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daab57aa610b3723cc39edf7c3e3365b
https://pubmed.ncbi.nlm.nih.gov/28854172
https://pubmed.ncbi.nlm.nih.gov/28854172
Publikováno v:
The Journal of clinical endocrinology and metabolism. 103(8)
Context Recent studies using skin biopsy suggest presence of small-fiber neuropathy in subclinical hypothyroidism. This study uses two noninvasive methods—the laser Doppler imager flare technique (LDIFLARE) and corneal confocal microscopy (CCM)—t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e430c02cf24177ba425a1acc120b403a
https://pubmed.ncbi.nlm.nih.gov/29860452
https://pubmed.ncbi.nlm.nih.gov/29860452
Autor:
Ansuman T. Satpathy, K. Mark Ansel, Nicolas Bray, Jeffrey A. Bluestone, Alice Y. Chan, Graham J. Ray, Dimitre R. Simeonov, Kyle Kai-How Farh, Theodore L. Roth, Zhongmei Li, Michelle L.T. Nguyen, Mark J. Daly, William J. Greenleaf, Kathrin Schumann, Gemma L. Curie, Mark S. Anderson, Ruize Liu, Chun Jimmie Ye, Howard Y. Chang, Alexander Marson, Dmytro Lituiev, Therese Mitros, Nicki Naddaf, Jacob E. Corn, Victoria Tobin, Meena Subramaniam, Maxwell R. Mumbach, Hailiang Huang, Benjamin G. Gowen, Rachel E. Gate, Julia S. Chu, John D. Gagnon, Hong Ma, Frédéric Van Gool, Youjin Lee, Eric Boyer, Jonathan M. Woo, Mandy Boontanrart
Publikováno v:
Nature, vol 549, iss 7670
The majority of genetic variants associated with common human diseases map to enhancers, non-coding elements that shape cell-type-specific transcriptional programs and responses to extracellular cues. Systematic mapping of functional enhancers and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67bd4330f085a76ad425b15ed30679cd
https://escholarship.org/uc/item/89t84794
https://escholarship.org/uc/item/89t84794
Autor:
Theodore L. Roth, Montse Morell, Kevan C. Herold, Jonathan S. Weissman, Victoria Tobin, Baz Smith, Cristina Puig-Saus, Gary M. Kupfer, Neil Romberg, Jean-Nicolas Schickel, Andrew P. May, Manuel D. Leonetti, Justin Saco, Kathrin Schumann, Alan Ashworth, Channabasavaiah B. Gurumurthy, Michael Haugwitz, David Carmody, Stephen H. Hughes, Joseph Hiatt, Andrea M. Ferris, Ying Mao, Ruby Yu, Jonathan Li, Gorka Alkorta-Aranburu, Julia Carnevale, Siri Atma W. Greeley, Rolen M. Quadros, Han Li, Hiroyuki Matsumoto, Eric Meffre, Maria Grazia Roncarolo, Antoni Ribas, Rosa Bacchetta, Jeff W. Chen, Daniela del Gaudio, Eric Shifrut, Laurence Pellerin, Alexander Marson, David N. Nguyen
Human T cells are central to physiological immune homeostasis, which protects us from pathogens without collateral autoimmune inflammation. They are also the main effectors in most current cancer immunotherapy strategies1. Several decades of work hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f04fa1cdf99e03953ad85a14a6fe5a7b
https://doi.org/10.1101/183418
https://doi.org/10.1101/183418