Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Victoria Splith"'
Autor:
Lisa Maria Riedmayr, Klara Sonnie Hinrichsmeyer, Stefan Bernhard Thalhammer, David Manuel Mittas, Nina Karguth, Dina Yehia Otify, Sybille Böhm, Valentin Johannes Weber, Michael David Bartoschek, Victoria Splith, Manuela Brümmer, Raphael Ferreira, Nanda Boon, Gabriele Maria Wögenstein, Christian Grimm, Jan Wijnholds, Verena Mehlfeld, Stylianos Michalakis, Stefanie Fenske, Martin Biel, Elvir Becirovic
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Large genes including several CRISPR-Cas modules like gene activators (CRISPRa) require dual adeno-associated viral (AAV) vectors for an efficient in vivo delivery and expression. Current dual AAV vector approaches have important limitations
Externí odkaz:
https://doaj.org/article/ed8130e2a4b84e5eb1442fbb00645d85
Autor:
Arshan Perera, David Eisen, Mirko Wagner, Silvia K. Laube, Andrea F. Künzel, Susanne Koch, Jessica Steinbacher, Elisabeth Schulze, Victoria Splith, Nana Mittermeier, Markus Müller, Martin Biel, Thomas Carell, Stylianos Michalakis
Publikováno v:
Cell Reports, Vol 11, Iss 2, Pp 283-294 (2015)
Ten-eleven translocation hydroxylases (TET1-3) oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). In neurons, increased 5hmC levels within gene bodies correlate positively with gene expression. The mechanisms controlling TET activity a
Externí odkaz:
https://doaj.org/article/efc027749c2f447a95d34c47412ad4b3
Autor:
Lisa M. Riedmayr, Klara S. Hinrichsmeyer, Nina Karguth, Sybille Böhm, Victoria Splith, Stylianos Michalakis, Elvir Becirovic
Publikováno v:
Nature protocols. 17(3)
Many disease-causing genes possess functionally equivalent counterparts, which are often expressed in distinct cell types. An attractive gene therapy approach for inherited disorders caused by mutations in such genes is to transcriptionally activate
Autor:
Stefanie Fenske, Jörn Walter, Elvir Becirovic, Johanna Wagner, Lisa Maria Riedmayr, Victoria Splith, Klara Sonnie Hinrichsmeyer, Karl Nordström, Gilles Gasparoni, Martin Biel, Christian Wahl-Schott, Sybille Böhm, Stylianos Michalakis, René D. Rötzer
Publikováno v:
Science Advances
Inherited blindness can be treated with a safe gene therapy approach using activation of functionally equivalent genes.
Catalytically inactive dCas9 fused to transcriptional activators (dCas9-VPR) enables activation of silent genes. Many disease
Catalytically inactive dCas9 fused to transcriptional activators (dCas9-VPR) enables activation of silent genes. Many disease
Autor:
Markus Müller, E. Schulze, Arshan Perera, Thomas Carell, Susanne Koch, Stylianos Michalakis, Silvia K. Laube, Nana Mittermeier, Andrea F. Künzel, Martin Biel, Mirko Wagner, David Eisen, Jessica Steinbacher, Victoria Splith
Publikováno v:
Cell Reports, Vol 11, Iss 2, Pp 283-294 (2015)
SummaryTen-eleven translocation hydroxylases (TET1-3) oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). In neurons, increased 5hmC levels within gene bodies correlate positively with gene expression. The mechanisms controlling TET act
Autor:
Victoria Splith, Sandra Berndt, Daniel Huster, Peter Schmidt, Kristina Witte, Lars Thomas, Annette G. Beck-Sickinger, Anette Kaiser
Publikováno v:
bchm. 394:1045-1056
In vitro folding of G protein-coupled receptors into a detergent environment represents a promising strategy for obtaining sufficient amounts of functional receptor molecules for structural studies. Typically, these preparations exhibit a poor long-t
Publikováno v:
Scientific Reports
Precise genome engineering is instrumental for biomedical research and holds great promise for future therapeutic applications. Site-specific recombinases (SSRs) are valuable tools for genome engineering due to their exceptional ability to mediate pr