Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Victoria Sanz-Moreno"'
Autor:
Eva Crosas-Molist, Vittoria Graziani, Oscar Maiques, Pahini Pandya, Joanne Monger, Remi Samain, Samantha L. George, Saba Malik, Jerrine Salise, Valle Morales, Adrien Le Guennec, R. Andrew Atkinson, Rosa M. Marti, Xavier Matias-Guiu, Guillaume Charras, Maria R. Conte, Alberto Elosegui-Artola, Mark Holt, Victoria Sanz-Moreno
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Cell migration is crucial for cancer dissemination. We find that AMP-activated protein kinase (AMPK) controls cell migration by acting as an adhesion sensing molecular hub. In 3-dimensional matrices, fast-migrating amoeboid cancer cells exer
Externí odkaz:
https://doaj.org/article/350286488c1e4475afc3dd506fdbc8ec
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2023)
Cell migration is crucial for efficient immune responses and is aberrantly used by cancer cells during metastatic dissemination. Amoeboid migrating cells use myosin II-powered blebs to propel themselves, and change morphology and direction. Immune ce
Externí odkaz:
https://doaj.org/article/ae362b5f8f7046c0b44475e039197863
Autor:
Oscar Maiques, Victoria Sanz-Moreno
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101879- (2022)
Summary: Here we describe a multiplex chromogenic immunohistochemistry platform to stain and analyze two markers in paraffin tissue sections from mouse or human. The basis of the protocol is a series of stripping and re-probing steps with subsequent
Externí odkaz:
https://doaj.org/article/224cafa47c55421bb3bae9f3d5a08d85
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101666- (2022)
Summary: Tumor-associated macrophages (TAMs) are key contributors to antitumor immunity. Here, we present a protocol to drive human monocyte-macrophage differentiation using tumor-derived conditioned media, followed by phenotypic and functional chara
Externí odkaz:
https://doaj.org/article/0280a5871dc14971ba16a222579766e5
Autor:
Rebecca Adams, Gabriel Osborn, Bipashna Mukhia, Roman Laddach, Zena Willsmore, Alicia Chenoweth, Jenny L C Geh, Alastair D MacKenzie Ross, Ciaran Healy, Linda Barber, Sophia Tsoka, Victoria Sanz-Moreno, Katie E Lacy, Sophia N Karagiannis
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
The application of monoclonal antibodies (mAbs) for the treatment of melanoma has significantly improved the clinical management of this malignancy over the last decade. Currently approved mAbs for melanoma enhance T cell effector immune responses by
Externí odkaz:
https://doaj.org/article/96ec4ae35e51463cbf1b5510ddb115e2
Autor:
Irene Rodriguez-Hernandez, Oscar Maiques, Leonie Kohlhammer, Gaia Cantelli, Anna Perdrix-Rosell, Joanne Monger, Bruce Fanshawe, Victoria L. Bridgeman, Sophia N. Karagiannis, Rosa M. Penin, Joaquim Marcolval, Rosa M. Marti, Xavier Matias-Guiu, Gilbert O. Fruhwirth, Jose L. Orgaz, Ilaria Malanchi, Victoria Sanz-Moreno
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Amoeboid cells are associated with melanoma invasive capacity. Here, the authors show that the WNT11-FZD7-DAAM1 pathway regulates tumour-initiating potential, invasion and metastasis lead by amoeboid cells in the invasive front of melanoma tumours.
Externí odkaz:
https://doaj.org/article/9e4929d31dc4466f83996eb59f8cabaf
Autor:
Charlotte M. de Winde, Samantha L. George, Eva Crosas-Molist, Yukti Hari-Gupta, Abbey B. Arp, Agnesska C. Benjamin, Lindsey J. Millward, Spyridon Makris, Alexander Carver, Valerio Imperatore, Víctor G. Martínez, Victoria Sanz-Moreno, Sophie E. Acton
Publikováno v:
iScience, Vol 24, Iss 9, Pp 102976- (2021)
Summary: Melanoma is an aggressive skin cancer developing from melanocytes, frequently resulting in metastatic disease. Melanoma cells utilize amoeboid migration as mode of local invasion. Amoeboid invasion is characterized by rounded cell morphology
Externí odkaz:
https://doaj.org/article/4ccbb9bd840641f084f5a6f000008701
Autor:
Jose L Orgaz, Victoria Sanz-Moreno
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 3 (2020)
Myosin II and its regulator Rho-associated coiled-coil containing protein kinase (ROCK) are essential for cell invasion and metastatic dissemination. Our recent findings show that this molecular machinery is also involved in drug resistance in melano
Externí odkaz:
https://doaj.org/article/7f997344a0564fe9b058fff5a433b77e
Autor:
Remi Samain, Victoria Sanz‐Moreno
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 4, Pp n/a-n/a (2020)
Non‐melanoma skin cancer (NMSC) is characterized by a strong desmoplastic reaction, largely responsible for cancer aggressiveness. Within the tumour microenvironment, cancer‐associated fibroblasts (CAFs) play a key role in tumour progression, sec
Externí odkaz:
https://doaj.org/article/63878967430d4d0eb5d3dab8314291cf
Autor:
Elizabeth Foxall, Adela Staszowska, Liisa M. Hirvonen, Mirella Georgouli, Mariacristina Ciccioli, Alexander Rimmer, Lynn Williams, Yolanda Calle, Victoria Sanz-Moreno, Susan Cox, Gareth E. Jones, Claire M. Wells
Publikováno v:
Cell Reports, Vol 31, Iss 3, Pp - (2020)
Externí odkaz:
https://doaj.org/article/e702d4baec494db8b413ecc7b47d8217