Synthesis and anti-HIV-1 integrase activity of modified dinucleotides

Autor: Julien Weiss, Ulysse Asseline, Victoria Roig, Gladys Mbemba, Marcel Chassignol, Jean-François Mouscadet, Hervé Meudal, Yves Aubert

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2009, 44 (12), pp.5029-5044. ⟨10.1016/j.ejmech.2009.09.007⟩

International audience; The synthesis of a series of thirty-eight new modified dinucleotides and dinucleotide conjugate analogues of d-(5')ApC(3') is described. The inhibitory activity of these compounds toward HIV-1 integrase was examined in enzymat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b81009d8f77303de16c83119891bf3e
https://doi.org/10.1016/j.ejmech.2009.09.007

Synthesis and characterization of o6-modified deoxyguanosine-containing oligodeoxyribonucleotides for triple-helix formation

Autor: Ulysse Asseline, Victoria Roig, Françoise Raynaud, Nguyen Thanh Thuong

Publikováno v: Tetrahedron. 52:2047-2064

Two new modified deoxyguanosine derivatives linked through their C-6 position to a psoralen and an acridine derivative have been synthesized and incorporated into oligonucleotide chains. Difficulties observed during the purification of oligonucleotid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0e4aae202a8f97965c1e2e4acb6be1c
https://doi.org/10.1016/0040-4020(95)01043-2

ChemInform Abstract: Solid-Phase Preparation of 5′,3′-Heterobifunctional Oligodeoxyribonucleotides Using Modified Solid Supports

Autor: Nguyen Thanh Thuong, Marcel Chassignol, R. Kurfuerst, Ulysse Asseline, Victoria Roig, Edwige Bonfils

Publikováno v: ChemInform. 23

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8078e0301350fc53ec225d57737e4a8
https://doi.org/10.1002/chin.199221289

Solid-phase preparation of 5′,3′-heterobifunctional oligodeoxyribonucleotides using modified solid supports

Autor: Victoria Roig, Nguyen Thanh Thuong, Edwige Bonfils, Ulysse Asseline, Marcel Chassignol, Robin Kurfurst

Publikováno v: Tetrahedron. 48:1233-1254

The solid-phase preparation of oligodeoxyribonucleotides attached to intercalator or reactive groups through their 5′- and (or) 3′-ends is reported. These syntheses implicate the introduction of suitable masked functional groups at the 5′-end o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09d9eeefbc27442e08cb38073ad22f9f
https://doi.org/10.1016/s0040-4020(01)90786-0

Triplex-forming oligonucleotide-orthophenanthroline conjugates for efficient targeted genome modification

Autor: Fabio Cannata, Carine Giovannangeli, Erika Brunet, Slimane Ait-Si-Ali, Ulysse Asseline, Loïc Perrouault, Jean-Paul Concordet, Victoria Roig

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2008, 105 (28), pp.9576-81. ⟨10.1073/pnas.0710433105⟩

International audience; The inefficiency of gene modification by homologous recombination can be overcome by the introduction of a double-strand break (DSB) in the target. Engineering the endonucleases needed, however, remains a challenging task that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba853f2767bbdd1b4ba237e58f21bf9
https://hal.archives-ouvertes.fr/hal-00408029