Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Victoria R. Pell"'
Autor:
Matthias Kohlhauer, Sam Dawkins, Ana S. H. Costa, Regent Lee, Timothy Young, Victoria R. Pell, Robin P. Choudhury, Adrian P. Banning, Rajesh K. Kharbanda, Kourosh Saeb‐Parsy, Michael P. Murphy, Christian Frezza, Thomas Krieg, Keith M. Channon
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 8 (2018)
BackgroundIschemia–reperfusion injury following ST‐segment–elevation myocardial infarction (STEMI) is a leading determinant of clinical outcome. In experimental models of myocardial ischemia, succinate accumulation leading to mitochondrial dysf
Externí odkaz:
https://doaj.org/article/bedd24e08820472c90591c552e76d292
Autor:
Pragalath Sadasivam, Filipa Mota, Victoria R. Pell, Richard Southworth, Nisha Singh, Ran Yan, Friedrich Baark, Edward C. T. Waters
Publikováno v:
Mota, F, Pell, V, Singh, N, Baark, F, Waters, E, Sadasivam, P, Southworth, R & Yan, R 2022, ' A reactivity-based 18F-labeled probe for PET imaging of oxidative stress in chemotherapy-induced cardiotoxicity ', Molecular Pharmaceutics, vol. 19, no. 1, pp. 18-25 . https://doi.org/10.1021/acs.molpharmaceut.1c00496
Oxidative stress underlies the pathology of many human diseases, including the doxorubicin-induced off-target cardiotoxicity in cancer chemotherapies. Since current diagnostic procedures are only capable of monitoring cardiac function, a noninvasive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b44aa5d990616c20e0f8d6936a553de
https://doi.org/10.1021/acs.molpharmaceut.1c00496
https://doi.org/10.1021/acs.molpharmaceut.1c00496
Autor:
Filipa, Mota, Victoria R, Pell, Nisha, Singh, Friedrich, Baark, Edward, Waters, Pragalath, Sadasivam, Richard, Southworth, Ran, Yan
Publikováno v:
Molecular Pharmaceutics
Oxidative stress underlies the pathology of many human diseases, including the doxorubicin-induced off-target cardiotoxicity in cancer chemotherapies. Since current diagnostic procedures are only capable of monitoring cardiac function, a noninvasive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a171a3aa1e908e72d64fe938b4e1a2ea
https://pubmed.ncbi.nlm.nih.gov/34846906
https://pubmed.ncbi.nlm.nih.gov/34846906
Autor:
Amin Mottahedin, Nils Burger, Thomas Krieg, Bijan Ghaleh, Christian Frezza, John F. Mulvey, Renaud Tissier, Matthias Kohlhauer, Ana-Mishel Spiroski, Anja V. Gruszczyk, Michael P. Murphy, Ana S. H. Costa, Victoria R. Pell
Publikováno v:
Basic Research in Cardiology. 114
Hypothermia induced at the onset of ischemia is a potent experimental cardioprotective strategy for myocardial infarction. The aim of our study was to determine whether the beneficial effects of hypothermia may be due to decreasing mitochondria-media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26b13f45a879dfed1ebb8a6301d73da6
https://doi.org/10.1007/s00395-019-0727-0
https://doi.org/10.1007/s00395-019-0727-0
Autor:
Kourosh Saeb-Parsy, Thomas Krieg, Andrew M. James, Michael P. Murphy, Lorraine M. Work, Edward T. Chouchani, Christian Frezza, Victoria R. Pell
Publikováno v:
Cell Metabolism. 23:254-263
Ischemia-reperfusion (IR) injury occurs when blood supply to an organ is disrupted--ischemia--and then restored--reperfusion--leading to a burst of reactive oxygen species (ROS) from mitochondria. It has been tacitly assumed that ROS production durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22313d1736d6fe0e15db370b0859c2ae
https://doi.org/10.1016/j.cmet.2015.12.009
https://doi.org/10.1016/j.cmet.2015.12.009
Myocardial ischaemia/reperfusion (IR) injury is a major cause of death worldwide and remains a disease for which current clinical therapies are strikingly deficient. While the production of mitochondrial reactive oxygen species (ROS) is a critical dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70035deee03ccf086cb89c2f8d5060c5
Autor:
Michael P. Murphy, Andrew M. James, Nils Burger, Victoria R. Pell, Ana-Mishel Spiroski, Tiziana Rosa, Thomas Krieg, Anja V. Gruszczyk, Christian Frezza, John F. Mulvey, Ana S. H. Costa, Angela Logan
Publikováno v:
Pell, V R, Spiroski, A-M, Mulvey, J, Burger, N, Costa, A S H, Logan, A, Gruszczyk, A V, Rosa, T, James, A M, Frezza, C, Murphy, M P & Krieg, T 2018, ' Ischemic preconditioning protects against cardiac ischemia reperfusion injury without affecting succinate accumulation or oxidation ', Journal of Molecular and Cellular Cardiology, vol. 123 . https://doi.org/10.1016/j.yjmcc.2018.08.010
Ischemia-reperfusion (IR) injury occurs when blood supply to an organ is disrupted and then restored, and underlies many disorders, notably myocardial infarction and stroke. While reperfusion of ischemic tissue is essential for survival, it also init
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5faaaf64930463caf5e8b6c8ad5fea2e
https://pubmed.ncbi.nlm.nih.gov/30118790
https://pubmed.ncbi.nlm.nih.gov/30118790
Autor:
Edward T. Chouchani, Michael P. Murphy, Thomas Krieg, Marleen Forkink, Brian K. Erickson, Ian M. Fearnley, Katja E. Menger, Gigi Y. Lau, Tracy A. Prime, Thomas P. Bright, Victoria R. Pell, Andrew M. James, Carmen Methner
Nitrate (NO3-) and nitrite (NO2-) are known to be cardioprotective and to alter energy metabolism in vivo NO3- action results from its conversion to NO2- by salivary bacteria, but the mechanism(s) by which NO2- affects metabolism remains obscure. NO2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3bafe3abe84c3da7b2373a2c31ff24e
Publikováno v:
Current Cardiovascular Imaging Reports
Purpose of Review In this review, we outline the potential for hypoxia imaging as a diagnostic and prognostic tool in cardiology. We describe the lead hypoxia PET radiotracers currently in development and propose a rationale for how they should most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb09d82137a2cbbc02ac6577178b7351
https://doi.org/10.1007/s12410-018-9447-3
https://doi.org/10.1007/s12410-018-9447-3
Autor:
Edward T, Chouchani, Andrew M, James, Carmen, Methner, Victoria R, Pell, Tracy A, Prime, Brian K, Erickson, Marleen, Forkink, Gigi Y, Lau, Thomas P, Bright, Katja E, Menger, Ian M, Fearnley, Thomas, Krieg, Michael P, Murphy
Publikováno v:
The Journal of Biological Chemistry
Nitrate (NO3−) and nitrite (NO2−) are known to be cardioprotective and to alter energy metabolism in vivo. NO3− action results from its conversion to NO2− by salivary bacteria, but the mechanism(s) by which NO2− affects metabolism remains o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8647e86067d2faa3b99f128b2f4d7d0a
https://pubmed.ncbi.nlm.nih.gov/28710281
https://pubmed.ncbi.nlm.nih.gov/28710281