Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Victoria Ozberk"'
Publikováno v:
Heliyon, Vol 10, Iss 9, Pp e30606- (2024)
To optimize immunogenicity, bacterial epitopes in putative vaccine constructs can be presented to immune cells as multiple repeated structures on a defined nanoparticle. Virus-like particles (VLPs) are viral capsid proteins that self-assemble to form
Externí odkaz:
https://doaj.org/article/2298725486984196b915245ef421c22f
Autor:
Jamie-Lee Mills, Ailin Lepletier, Victoria Ozberk, Jessica Dooley, Jacqualine Kaden, Ainslie Calcutt, Yongbao Huo, Allan Hicks, Ali Zaid, Michael F. Good, Manisha Pandey
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionStreptococcus pyogenes is a Gram-positive pathogen that causes a significant global burden of skin pyoderma and pharyngitis. In some cases, infection can lead to severe invasive streptococcal diseases. Previous studies have shown that IL-
Externí odkaz:
https://doaj.org/article/fd3c1d30a5e645bf9534f9da2df33d4a
Autor:
Victoria Ozberk, Mehfuz Zaman, Ailin Lepletier, Sharareh Eskandari, Jacqualine Kaden, Jamie-Lee Mills, Ainslie Calcutt, Jessica Dooley, Yongbao Huo, Emma L. Langshaw, Glen C. Ulett, Michael R. Batzloff, Michael F. Good, Manisha Pandey
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Mucosally active subunit vaccines are an unmet clinical need due to lack of licensed immunostimulants suitable for vaccine antigens. Here, we show that intranasal administration of liposomes incorporating: the Streptococcus pyogenes peptide
Externí odkaz:
https://doaj.org/article/6a7065b93c674ba3bb43501a205f2afc
Autor:
Shuxiong Chen, Victoria Ozberk, Gayathri Sam, Zennia Jean C. Gonzaga, Ainslie Calcutt, Manisha Pandey, Michael F. Good, Bernd H. A. Rehm
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-11 (2023)
Abstract Group A Streptococcus (Strep A) is a life-threatening human pathogen with no licensed vaccine. Here, we used a biopolymer particle (BP) approach to display repeats of Strep A vaccine candidate peptides p*17 and K4S2 derived from M and non-M
Externí odkaz:
https://doaj.org/article/b0cf4e385685433891852904f2183f0d
Autor:
Emma L. Langshaw, Simone Reynolds, Victoria Ozberk, Jessica Dooley, Ainslie Calcutt, Mehfuz Zaman, Mark J. Walker, Michael R. Batzloff, Mark R. Davies, Michael F. Good, Manisha Pandey
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Mutation within the Streptococcus pyogenes (Streptococcus group A; Strep A) covR/S regulatory system has been associated with a hypervirulent phenotype resulting from the upregulation of several virulence factors, including the pore-forming
Externí odkaz:
https://doaj.org/article/f1d1a8111f9c42cc991b8d58bf71c93d
Autor:
Zachary N. Phillips, Claudia Trappetti, Annelies Van Den Bergh, Gael Martin, Ainslie Calcutt, Victoria Ozberk, Patrice Guillon, Manisha Pandey, Mark von Itzstein, W. Edward Swords, James C. Paton, Michael P. Jennings, John M. Atack
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 3 (2022)
ABSTRACT Streptococcus pneumoniae is the most common cause of bacterial illness worldwide. Current vaccines based on the polysaccharide capsule are only effective against a limited number of the >100 capsular serotypes. A universal vaccine based on c
Externí odkaz:
https://doaj.org/article/68f9c1ea19634bfb9653d1784a3d28cf
Autor:
Simone Reynolds, Manisha Pandey, Jessica Dooley, Ainslie Calcutt, Michael Batzloff, Victoria Ozberk, Jamie-Lee Mills, Michael Good
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract We have developed two candidate vaccines to protect against multiple strains of Strep A infections. The candidates are combinatorial synthetic peptide vaccines composed of a M protein epitope (J8 or p*17) and a non-M protein epitope (K4S2).
Externí odkaz:
https://doaj.org/article/9658d25da71b425b9c969603708be127
Autor:
Victoria Ozberk, Simone Reynolds, Yongbao Huo, Ainslie Calcutt, Sharareh Eskandari, Jessica Dooley, Jamie-Lee Mills, Ida S. Rasmussen, Jes Dietrich, Manisha Pandey, Michael F. Good
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
A vaccine to control S. pyogenesS. pyogenes
Externí odkaz:
https://doaj.org/article/93132b2231c849d88f2567bd033070f5
Autor:
Manisha Pandey, Victoria Ozberk, Sharareh Eskandari, Ahmed O Shalash, Michael A Joyce, Holly A Saffran, Christopher J Day, Ailin Lepletier, Belinda L Spillings, Jamie‐Lee Mills, Ainslie Calcutt, Fan Fan, James T Williams, Danielle I Stanisic, Laetitia Hattingh, John Gerrard, Mariusz Skwarczynski, Johnson Mak, Michael P Jennings, Istvan Toth, D Lorne Tyrrell, Michael F Good
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 3, Pp n/a-n/a (2021)
Abstract Objectives A major COVID‐19 vaccine strategy is to induce antibodies that prevent interaction between the Spike protein's receptor‐binding domain (RBD) and angiotensin‐converting enzyme 2 (ACE2). These vaccines will also induce T‐cel
Externí odkaz:
https://doaj.org/article/e84bde1bc9874220bdf3a2aceb319bda
Autor:
Mehfuz Zaman, Victor C Huber, Dustin L Heiden, Katerina N DeHaan, Sanyogita Chandra, Demi Erickson, Victoria Ozberk, Manisha Pandey, Benjamin Bailly, Gael Martin, Emma L Langshaw, Ali Zaid, Mark vonItzstein, Michael F Good
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 9, Pp n/a-n/a (2021)
Abstract Objectives The upper respiratory tract is the major entry site for Streptococcus pyogenes and influenza virus. Vaccine strategies that activate mucosal immunity could significantly reduce morbidity and mortality because of these pathogens. T
Externí odkaz:
https://doaj.org/article/74e432a6e1574a4db2f011bf4476c694